NEUROBEHAVIORAL OUTCOME OF TEMPORAL LOBECTOMY

颞叶切除术的神经行为结果

• 批准号: 3415474
• 负责人: ANDREW J SAYKIN
• 金额: $ 18.05万
• 依托单位: GRADUATE HOSPITAL (PHILADELPHIA)
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3415474
• 关键词: behavioral medicine; brain interhemispheric activity; cognition; electroencephalography; electrophysiology; epilepsy; female; generalized seizures; handedness; human subject; longitudinal human study; magnetic resonance imaging; male; memory; neuropsychological tests; neuropsychology; neurosurgery; partial seizure; performance; personality tests; positron emission tomography; psychological tests; social adjustment; temporal lobe /cortex

DESCRIPTION (Adapted from Investigator's Abstract): This revised application is a proposal aimed at determining the potential of preoperative neurobehavioral data as predictors of outcome of anterior temporal lobectomy (ATL), and expanding the traditional end point of seizure outcome to include neurobehavioral consequences (neuropsychological and psychosocial). Predictors will consist of preoperative neuropsychological measures (cognition, memory, language, musical perception, attention; results of intracarotid amytal memory procedures), psychosocial measures (psychopathology, affect, activities of daily living and vocational status), EEG (extra- and intracranial, ictal and interictal) MRI and PET (in a subsample). In a prospective longitudinal design, 30 new patients per year (total n=120) will be evaluated preoperatively and reevaluated 2 weeks, 12 months and then 24 months after surgery. Recently operated patients (n=60) with baseline data will be similarly studied, with a potential follow-up of up to 10 years. They will be compared to non-operated patients with partial epilepsy (n=30) and normal controls (n=30) studied at the same intervals. Systematic examination of interactions between the predictor variables and reorganization underlying outcome. For example, the investigators will test the hypothesis that better postoperative memory and seizure control is obtained in patients with greater specificity of neural lateralization of neurobehavioral and EEG markers and presence of neuropsychological abnormality. The investigators will also attempt to establish objective criteria for neurobehavioral outcome of ATL including the exploration and validity of several new measures.

描述（根据调查员的摘要进行了改编）：此修订 应用是一项旨在确定潜力的建议 术前神经行为数据，作为前部预后的预测指标 颞叶切除术（ATL），并扩大了传统的终点 癫痫发作结果包括神经行为后果（神经心理学 和社会心理）。 预测因子将包括术前 神经心理学措施（认知，记忆，语言，音乐 感知，注意；核内杏仁核记忆过程的结果）， 社会心理措施（心理病理学，情感，日常生活活动 和职业地位），脑电图（外部和颅内，杂物和临时） MRI和PET（在子样本中）。 在预期的纵向设计中，30个新 每年患者（总n = 120）将进行术前评估，并 在手术后2周，12个月以及24个月重新评估。 最近 将类似地研究具有基线数据的手术患者（n = 60）， 最多可长达10年的随访。 他们将被比较 部分癫痫（n = 30）和正常对照的非手术患者 （n = 30）以相同的间隔进行了研究。 系统检查 预测变量和重组之间的相互作用 结果。 例如，调查人员将检验以下假设 在患者中获得更好的术后记忆和癫痫发作控制 具有更大的神经神经横向化特异性和 脑电图标记和神经心理异常的存在。 这 调查人员还将试图建立客观标准 ATL的神经行为结果，包括探索和有效性 几个新措施。