Chronic effects of different THC:CBD ratios on executive function and emotional processing in people with multiple sclerosis

不同 THC:CBD 比例对多发性硬化症患者执行功能和情绪处理的慢性影响

• 批准号: 10369773
• 负责人: Thorsten Rudroff
• 金额: $ 23.18万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10369773
• 关键词: Acute; Affect; Anti-Anxiety Agents; Anti-Inflammatory Agents; Anxiety; Area; Benefits and Risks; Brain; Cannabidiol; Cannabis; Cerebrum; Chronic; Cross-Sectional Studies; Data; Emotional; Executive Dysfunction; Exhibits; Fright; Future; Goals; Impairment; Iowa; Knowledge; Left; Longitudinal Studies; Measures; Medial; Multiple Sclerosis; Muscle Spasticity; Neuropsychology; Observational Study; Performance; Persons; Policies; Positioning Attribute; Positron-Emission Tomography; Psychoses; Quality of life; Regulation; Research; Research Personnel; Symptoms; Testing; Tetrahydrocannabinol; base; comorbidity; executive function; fluorodeoxyglucose; glucose uptake; improved; marijuana use; painful neuropathy; symptom management; uptake

Project Summary Approximately 70% of people with multiple sclerosis (PwMS) self-medicate their symptoms with cannabis. Δ-9- tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most abundant cannabis components. THC exhibits psychoactive effects, may induce acute psychosis, and impacts executive function. CBD is not psychoactive like THC and has been shown to be emotionally beneficial (i.e., anxiolytic), anti-inflammatory, and neuroprotective. Critically, there is a vast diversity in the amounts (i.e., ratios) of THC and CBD commercially available. Therefore, the ratio of THC: CBD of various strains of cannabis may have a pivotal impact on executive function and emotional processing (i.e., fear, anxiety) in PwMS. Currently, there is a gap of understanding surrounding the effects of different ratios of THC:CBD on brain activity, executive function, and emotional processing in PwMS. The goal of this application is to conduct a unique observational, cross-sectional study that employs real-world cannabis products of varying THC:CBD ratios currently available to Iowa residents. We will investigate differences in executive function, emotional processing, and brain activity in PwMS who have been using different THC:CBD ratios of cannabis for at least 6 months [High CBD group (CBD >THC); 1:1 group (THC = CBD); High THC group (THC > CBD); Non-Users group (no cannabis)]. Executive function and emotional processing will be assessed with valid psychiatric and neuropsychological measures. Positron Emission Tomography (PET) with [18F]-Fluorodeoxyglucose (FDG) will be used as a measure of brain activity. Our central hypothesis is that the High THC group will have worse executive function and emotional processing compared to the High CBD, 1:1, and Non-Users groups, and that the High CBD group will have better emotional processing compared to the High THC, 1:1, and Non-Users groups. These hypotheses were formulated based on previous studies and our own preliminary data. This research on PwMS who are currently using cannabis is well-positioned to critically inform our understanding of the effects of different THC:CBD ratios and highlight avenues for future longitudinal studies (R01).

项目概要 大约 70% 的多发性硬化症 (PwMS) 患者使用大麻自行治疗症状。 四氢大麻酚（THC）和大麻二酚（CBD）是最丰富的大麻成分。 CBD 表现出精神作用，可能诱发急性精神病，并影响执行功能。 与 THC 类似的精神活性物质，已被证明对情绪有益（即抗焦虑）、抗炎、 至关重要的是，THC 和 CBD 的含量（即比例）存在巨大差异。 因此，THC：CBD的比例对各种大麻品种可能具有关键作用。 PwMS 对执行功能和情绪处理（即恐惧、焦虑）的影响目前还存在差距。 了解不同比例的 THC:CBD 对大脑活动、执行功能、 PwMS 中的情绪处理。 该应用程序的目标是进行一项独特的观察性横断面研究，该研究采用现实世界 我们将调查目前向爱荷华州居民提供的不同 THC:CBD 比例的大麻产品。 一直使用 PwMS 的人在执行功能、情绪处理和大脑活动方面存在差异 不同 THC:CBD 比例的大麻至少 6 个月[高 CBD 组（CBD > THC）；1:1 组（THC = CBD）；高 THC 组（THC > CBD）；非使用者组（无大麻）]。 将通过有效的精神病学和神经心理学测量来评估处理过程。 [18F]-氟脱氧葡萄糖 (FDG) 断层扫描 (PET) 将用于测量大脑活动。 我们的中心假设是，高 THC 群体的执行功能和情绪会更差。 与高 CBD、1:1 和非用户组相比，高 CBD 组将有 与高 THC、1:1 和非使用者组相比，这些假设具有更好的情绪处理能力。 根据之前的研究和我们自己的初步数据制定。 这项针对目前正在使用大麻的 PwMS 的研究非常适合为我们提供重要的信息 了解不同 THC:CBD 比例的影响并强调未来纵向研究的途径 （R01）。