Neural signatures of dynamic threat processing in youth

青少年动态威胁处理的神经特征

基本信息

批准号：
10448487
负责人：
MICHAEL J CROWLEY
金额：
$ 20.94万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10448487
关键词：
14 year old Acute Address Affect Affective Age Anxiety Anxiety Disorders Attention Base of the Brain Behavior Behavioral Biological Assay Biological Markers Brain Cartoons Child Chronic Clinical Clinical Trials Communities Complex Cues Data Detection Development Distress Electroencephalography Environment Environmental Risk Factor Face Foundations Functional disorder Future Image Individual Individual Differences Intervention Knowledge Lead Life Maintenance Measures Mental Depression Methods Modeling Names National Institute of Mental Health Nature Negative Valence Outcome Parents Participant Persons Phenotype Potato Prevention Process Psychometrics Psychopathology Public Health Quality of life Reporting Research Research Domain Criteria Research Personnel Research Support Risk Severities Signal Transduction Stimulus Strategic Planning Suggestion System Testing Time Translations Update Validation Validity and Reliability Work Youth anxious anxious individuals childhood anxiety comorbidity cost design economic cost follow-up girls informant insight lens multidisciplinary novel personalized intervention relating to nervous system response vigilance

项目摘要

PROJECT SUMMARY Anxiety disorders are near the top of the list of the most troublesome public health concerns we face, costing billions of dollars annually. Equally important are the many individual lives devastated by debilitating distress and chronic avoidance, leading to diminished quality of life, lost potential and emergent comorbid conditions (e.g. depression). Chronic, abnormally heightened threat processing is a linchpin in the pathophysiology and maintenance of anxiety disorders. Research to date on threat processing in anxiety has used passive viewing of static threat stimuli. However, real-life threats are not static—the nature of threats changes over time. We propose to remedy this important limitation of the extant research with a dynamic threat processing game (the Boom). The Boom is designed to assess a profile of neural responses to dynamically evolving threats among youth with and without elevated anxiety. The Boom is developmentally sensitive, engaging for youth, and calibrated for the detection of individual differences in threat processing. Employing child-friendly cartoon-like images, the game assesses youths’ processing of successive, naturally-evolving threat contexts: vigilance for potential threats, followed by detection of direct or indirect acute threats, and an opportunity to reappraise indirect threats that do not require an immediate response. We propose a multi-method (EEG, behavior, and multi- informant phenotyping) study to evaluate the validity and reliability of the Boom for assessing 10- to 14- year-olds’ neural responses to dynamically evolving threat contexts, to begin to unpack successive stages in a threat processing cascade among community and clinically-referred youth with varying anxiety severity. The Boom provides a unique lens into dynamic threat processing disruptions in anxiety that are not measured by existing assessments. However, establishing the reliability and validity of the Boom is a critical first step. Following psychometric validation, we expect the Boom will yield important insights into mechanisms contributing to the development and maintenance of anxiety disorders. This work may inform the design of novel or personalized interventions for anxiety disorders targeting dynamic threat processing disruptions. This study will deliver quantitative, developmentally informed brain-based biomarkers, for two key Research Domain Criteria (RDoC) negative valence constructs, Potential Threat and Acute Threat. Moreover, this project is well-aligned with the NIMH Strategic Plan Strategy 1.1, which includes identification and validation of novel assays to quantify changes in the activity of brain circuits.

项目概要焦虑症几乎位居我们面临的最麻烦的公共卫生问题的首位，同样重要的是，许多人的生活因衰弱的痛苦而遭受破坏。长期回避，导致生活质量下降、潜力丧失和出现合并症（例如，抑郁症）。慢性、异常的哮喘威胁处理是病理生理学和疾病的关键。迄今为止，关于焦虑中威胁处理的研究一直使用被动观看。然而，现实生活中的威胁并不是静态的——威胁的性质会随着时间的推移而变化。补救措施提出现有研究的动态威胁处理游戏的这一重要局限性（ Boom 旨在评估对动态变化的威胁的神经反应概况。无论有或没有高度焦虑的青少年，“繁荣”都是发展敏感的，对青少年有吸引力，并且采用适合儿童的卡通风格来检测威胁处理中的个体差异。通过图像，该游戏评估了青少年对连续的、自然演变的威胁环境的处理能力：对威胁的警惕性潜在威胁，然后检测直接或间接严重威胁，并有机会重新评估间接威胁我们提出了一种多种方法（脑电图、行为和多种方法）。线人表型）研究评估 Boom 评估 10- 至 14- 的有效性和可靠性岁儿童对动态变化的威胁环境的神经反应，开始解开连续的威胁社区和临床转介的青少年之间威胁处理级联的各个阶段焦虑的严重程度提供了一个独特的视角来观察焦虑中的动态威胁处理中断。然而，确定繁荣的可靠性和有效性是一个必要的工作。在关键的第一步验证之后，我们预计繁荣将产生重要的见解。有助于焦虑症的发展和维持的机制这项工作可能会为焦虑症的发展和维持提供信息。针对动态威胁处理的焦虑症设计新颖或个性化的干预措施这项研究将为两个关键的、基于发育的大脑生物标志物提供定量的信息。研究领域标准 (RDoC) 负价结构、潜在威胁和急性威胁。该项目与 NIMH 战略计划战略 1.1 非常一致，其中包括识别和验证量化脑回路活动变化的新方法。