DESIGN AND ASSEMBLY OF A DEVICE TO COOL THE DENTAL PULP

牙髓冷却装置的设计和组装

• 批准号: 3425395
• 负责人: HAROLD E GOODIS
• 金额: $ 2.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-25 至 1991-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425395
• 关键词: cold injury; cryopreservation; dental pulp; dentin; disease /disorder model; heat injury; inflammation; model design /development; oral facial restoration material

The specific aims of the project are to construct a safe device to cool the dental pulp and to evaluate the performance characteristics of that device in vitro. The long term objectives of this project are to determine the thermal conductivity and heat transfer capabilities of the dental pulp in relation to the surrounding dentin. Studies on the effects of lowering intrapulpal temperature on the vasculature, circulation and neurocomponents of the dental pulp will be carried out. The above investigations will lead to a method of preventing temperature increases and resultant inflammatory reactions within the pulp due to restorative procedures. The experimental design is to construct two supporting cooling systems which will contact the test teeth. CO2 coolant will be circulated through the systems to temperature level of 0 degrees celsius to 5 degrees celsius, 5 degrees celsius to 10 degrees celsius, and 10 degrees celsius to 15 degrees celsius. Each level will be cooled for a 20 minute time period in an in vitro model consisting of young first bicuspids and third molars extracted for orthodontic reasons. Temperatures will be measured by placing thermocouples to the DEJ and PDJ and placing the cooling systems in contact with all surfaces of the test tooth. Test results will provide the basis for investigations into the thermal conductivity and heat transfer mechanisms of the dental pulp and surrounding dentins as well as the ability to study the effects of temperature change (cooling) on the vasculature, circulation and neurocomponents of the dental pulp. The successful construction of the device will finally lead to a method of preventing temperature increases and resultant inflammatory reactions within the pulp as a result of restorative procedures.

该项目的具体目的是构建一个安全的设备以冷却 牙纸浆并评估其性能特征 体外设备。 该项目的长期目标是 确定电导率和传热能力 与周围牙本质相关的牙髓。 研究 降低硫磺内温度对脉管系统的影响， 将进行牙髓的循环和神经组件。 上述研究将导致预防温度的方法 由于 恢复程序。 实验设计是构造两个 支持将与测试牙齿接触的冷却系统。 二氧化碳 冷却液将通过系统循环到0 摄氏摄氏度至5摄氏度，5摄氏度至10度 摄氏和10摄氏度至15摄氏度。 每个级别都会 在体外模型中冷却20分钟的时间段 出于正畸原因，年轻的第一双刺和第三磨牙提取。 将通过将热电偶放入DEJ和PDJ来测量温度 并将冷却系统与测试的所有表面接触 齿。 测试结果将为调查的基础 牙髓的热导率和传热机制， 周围的牙本质以及研究的能力 脉管系统，循环和循环的温度变化（冷却） 牙髓的神经组件。 成功构造 设备最终将导致预防温度升高的方法 以及由于果肉内导致的炎症反应 恢复程序。