Field Instrument for Assessment of Arsenic Exposure
砷暴露评估现场仪器
基本信息
- 批准号:10484041
- 负责人:
- 金额:$ 84.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-09 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcuteAreaArsenicAssessment toolBiological AssayBiological MarkersBloodBody FluidsCadmiumChronicClinicalCollaborationsCommunitiesCommunity HealthComplexComputer softwareCountryCoupledDetectionDevelopmentDiseaseElectronicsEnsureEnvironmentEnvironmental ExposureEnvironmental HealthEnvironmental PollutantsEpidemiologistEpidemiologyEquipmentEvaluationExposure toFoodFreezingGoalsHealthHeavy MetalsHigh Pressure Liquid ChromatographyHumanIndustrializationIngestionInhalationInstitutionInternationalInvestmentsLab On A ChipLaboratoriesLeadLettersLiquid substanceManganeseMass Spectrum AnalysisMeasurementMeasuresMedicalMetal exposureMetalsMethodsMicrofluidic MicrochipsMicrofluidicsMonitorOutcomePerformancePhasePhysiologicalPlasmaPopulationPopulations at RiskPrevalencePublic HealthPublic Health SchoolsReagentResearch PersonnelResolutionRiskSafetySamplingScienceScientistSeriesSiteSoilSourceSpecialistSystemTechnologyTestingTimeToxic effectTrace metalTrainingTransportationUniversitiesUrineValidationVial deviceWaterWorkanalytical methodbioaccumulationcommercializationcomputerized data processingcontaminated drinking watercostcost effectivedata qualitydata toolsdesigndetection limitdetection methoddiagnostic technologiesdisorder preventiondrinking waterepidemiology studyexperienceexposed human populationfabricationfield studyhealth science researchhealthcare communityhuman subjecthuman tissueimprovedinstrumentinterestmedical schoolsmetal poisoningnext generationoperationportabilityportable monitoringpreventprogramsprototyperapid testingreal time monitoringresponsescreeningsensorsensor technologyskillssuperfund sitetooltoxic metalurinaryusability
项目摘要
Project Summary
Human exposure to toxic heavy metals existing in drinking water, food, and the environment is an area of
increasing national and international concern. Heavy metals are significant environmental pollutants because
they tend to persist, bioaccumulate and can result in serious adverse acute or chronic health effects after
ingested or inhaled. Traditionally, trace metals are measured from human tissues or fluids (blood or urine) in
centralized laboratories using complex analytical methods such as high-performance liquid chromatography
(HPLC) or inductively coupled plasma mass spectroscopy (ICP-MS). However, in view of the intensive labor,
analytical costs and long turnaround times associated with centralized laboratory analyses, there is an immediate
need for a portable and inexpensive system for on-site monitoring of human exposure to heavy metals. These
rapid, field measurements of human exposure in the population would greatly help epidemiology researchers to
conduct their studies and also help the regulatory institutions with better determination of safety limits and
prevention of diseases caused by heavy metal exposures.
An important goal of this Direct to Phase II proposal is to develop a technology that meet the technical and
practical needs of environmental researchers, clinicians, and epidemiologists. The ultimate goal is to deliver a
reliable field prototype of a sensing instrument for the current unmet needs for rapid testing of trace amounts of
metals in urine samples, and to accelerate the commercialization of this product. In this Phase IIB study, Giner
will develop and demonstrate the heavy metals monitor prototype from bench-top assay platform to a field-ready
instrument with a portable size, with integrated components for assay operation, electronic units and software
packages for data processing and user interface. Meanwhile Giner will develop and fabricate a series of
disposable microfluidic lab-on-a-chip cartridge for convenient measurements of multiple metal(s) and metal
combinations from large numbers of human subjects. The various cartridge designs will allow the monitor
instrument to determine the presence and concentrations of multiple metals. The overall performances of the
prototype will then be evaluated thoroughly through a large scale of field testing with four renowned epidemiology
collaborators, as well as a team of user experience specialists, which would improve the sensing capabilities,
tool reliability and usability towards commercialization.
This proposed project will achieve a critical step towards the commercial release of a heavy metal field monitor,
which has the potential to become a critical tool to support environmental and public health community for
developing strategies to prevent toxic metals-related diseases. Giner is teaming up with leading commercial
partners which specialize in the development and commercialization of screening and diagnostic technologies.
项目概要
人类接触饮用水、食物和环境中存在的有毒重金属是一个领域
日益增加的国家和国际关注。重金属是重要的环境污染物,因为
它们往往会持续存在、生物累积,并可能在使用后对健康造成严重的急性或慢性不良影响。
摄入或吸入。传统上,微量金属是从人体组织或液体(血液或尿液)中测量的
使用高效液相色谱等复杂分析方法的集中实验室
(HPLC) 或电感耦合等离子体质谱 (ICP-MS)。但考虑到劳动强度大,
与集中实验室分析相关的分析成本和较长的周转时间,可以立即
需要一种便携式且廉价的系统来现场监测人体接触重金属的情况。这些
对人群中人类暴露情况的快速现场测量将极大地帮助流行病学研究人员
进行研究并帮助监管机构更好地确定安全限值和
预防因重金属接触引起的疾病。
该直接进入第二阶段提案的一个重要目标是开发一种满足技术和要求的技术。
环境研究人员、临床医生和流行病学家的实际需求。最终目标是提供一个
可靠的传感仪器现场原型,可满足当前未满足的快速测试微量物质的需求
尿液样本中的金属,并加速该产品的商业化。在这项 IIB 期研究中,Giner
将开发并演示从台式分析平台到现场就绪的重金属监测仪原型
仪器具有便携式尺寸,带有用于分析操作的集成组件、电子单元和软件
用于数据处理和用户界面的包。同时Giner将开发和制造一系列
一次性微流控芯片实验室卡盒,可方便测量多种金属和金属
来自大量人类受试者的组合。各种墨盒设计将使显示器
测定多种金属的存在和浓度的仪器。整体表现
然后,将通过四位著名流行病学专家的大规模现场测试对原型进行彻底评估
合作者以及用户体验专家团队,这将提高传感能力,
工具的可靠性和可用性以实现商业化。
该拟议项目将朝着重金属现场监测仪的商业发布迈出关键一步,
它有潜力成为支持环境和公共卫生界的重要工具
制定预防有毒金属相关疾病的策略。 Giner 正在与领先的商业公司合作
专门从事筛查和诊断技术的开发和商业化的合作伙伴。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Avni A Argun其他文献
Avni A Argun的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Avni A Argun', 18)}}的其他基金
Population monitoring of stress markers in underserved communities
服务欠缺社区压力标记的人口监测
- 批准号:
10766447 - 财政年份:2023
- 资助金额:
$ 84.51万 - 项目类别:
At-home Testing of Blood Sodium for Management of Diabetes Insipidus
在家检测血钠以治疗尿崩症
- 批准号:
10395189 - 财政年份:2021
- 资助金额:
$ 84.51万 - 项目类别:
Electrochemical Assay to Monitor Anti-TB Antibiotics
监测抗结核抗生素的电化学测定
- 批准号:
10010646 - 财政年份:2021
- 资助金额:
$ 84.51万 - 项目类别:
Rapid Assessment of Illicit Drugs in Wastewater
废水中非法药物的快速评估
- 批准号:
10397306 - 财政年份:2020
- 资助金额:
$ 84.51万 - 项目类别:
Rapid Assessment of Illicit Drugs in Wastewater
废水中非法药物的快速评估
- 批准号:
10576367 - 财政年份:2020
- 资助金额:
$ 84.51万 - 项目类别:
Rapid, Multiplexed Biosensor for Non-Invasive Detection of Gene Mutations and Personalization of Therapy in Non-Small Cell Lung Cancer
用于非小细胞肺癌基因突变非侵入性检测和个性化治疗的快速多重生物传感器
- 批准号:
10480889 - 财政年份:2019
- 资助金额:
$ 84.51万 - 项目类别:
Rapid, Multiplexed Biosensor for Non-Invasive Detection of Gene Mutations and Personalization of Therapy in Non-Small Cell Lung Cancer
用于非小细胞肺癌基因突变非侵入性检测和个性化治疗的快速多重生物传感器
- 批准号:
10471039 - 财政年份:2019
- 资助金额:
$ 84.51万 - 项目类别:
Non-Invasive, Highly Specific Detection of Oxytocin in Biological Fluids
非侵入性、高特异性检测生物体液中的催产素
- 批准号:
9131542 - 财政年份:2016
- 资助金额:
$ 84.51万 - 项目类别:
相似国自然基金
巨噬细胞Nogo-B通过FABP4/IL-18/IL-18R调控急性肝衰竭的分子机制研究
- 批准号:82304503
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
α7nAChR激动剂通过PGC-1α和HO-1调控肾小管上皮细胞线粒体的质和量进而改善脓毒症急性肾损伤的机制研究
- 批准号:82372172
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
基于解郁散热“把好气分关”探讨代谢-炎症“开关”A2BR在急性胰腺炎既病防变中的作用与机制
- 批准号:82374256
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
RacGAP1介导细胞核-线粒体对话在急性肾损伤中促进肾小管上皮细胞能量平衡的作用机制研究
- 批准号:82300771
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
开窍寒温配伍调控应激颗粒铁离子富集水平抗急性缺血性卒中铁死亡损伤的机制研究
- 批准号:82374209
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
相似海外基金
Evaluating the impacts of sea level rise on migration and wellbeing in coastal communities
评估海平面上升对沿海社区移民和福祉的影响
- 批准号:
10723570 - 财政年份:2023
- 资助金额:
$ 84.51万 - 项目类别:
Pandemic preparedness for underserved persons in the US: Harnessing data from the RADx-UP consortium to assess public health tools for resource allocation
美国服务不足人群的流行病防范:利用 RADx-UP 联盟的数据评估用于资源分配的公共卫生工具
- 批准号:
10881319 - 财政年份:2023
- 资助金额:
$ 84.51万 - 项目类别:
B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers
传染病、自身免疫和 B 细胞癌症背景下的 B 细胞生物学
- 批准号:
10683443 - 财政年份:2023
- 资助金额:
$ 84.51万 - 项目类别:
Feasibility of Using PET Imaging for Detection of Treatment-Induced Changes in Chronic Neuroinflammation Following TBI
使用 PET 成像检测 TBI 后治疗引起的慢性神经炎症变化的可行性
- 批准号:
10703823 - 财政年份:2023
- 资助金额:
$ 84.51万 - 项目类别:
Music4Pain Network: A research network to advance the study of mechanisms underlying the effects of music and music-based interventions on pain.
Music4Pain Network:一个研究网络,旨在推进音乐和基于音乐的疼痛干预措施的影响机制的研究。
- 批准号:
10764417 - 财政年份:2023
- 资助金额:
$ 84.51万 - 项目类别: