National Clinical Trials Network Research at the University of Wisconsin

威斯康星大学国家临床试验网络研究

• 批准号: 10358646
• 负责人: Lisa M Barroilhet
• 金额: $ 55.93万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-06 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10358646
• 关键词: American College of Radiology Imaging Network; American College of Surgeons Oncology Group; Cancer Burden; Cancer Center; Cancer Patient; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Cooperative Group Program; Data; Development; Eastern Cooperative Oncology Group; Ensure; Faculty; Goals; Grant; Gynecologic Oncology; Gynecologic Oncology Group; Image; Imaging Techniques; Infrastructure; Leadership; Malignant Neoplasms; Medical Oncology; Mission; Modernization; NCI Center for Cancer Research; National Clinical Trials Network; Oncology; Phase; Phase II/III Clinical Trial; Population; Population Heterogeneity; Prevention; Principal Investigator; Protocols documentation; Radiation Oncology; Radiation Therapy Oncology Group; Research; Research Infrastructure; Research Personnel; Resources; Strategic Planning; Structure; Surgical Oncology; Therapeutic; Time; Translational Research; Underserved Population; Universities; University of Wisconsin Comprehensive Cancer Center; Wisconsin; cancer clinical trial; cancer education; cancer therapy; data management; design; experience; innovation; interdisciplinary approach; interest; multidisciplinary; next generation; novel; programs; treatment trial

Project Summary/Abstract The University of Wisconsin Carbone Cancer Center (UWCCC), its leadership, and its faculty are driven by a mission to defeat cancer through rapid application of groundbreaking research in cancer education, prevention and treatment. Embedded in the UWCCC's strategic plan are tactics for expanding a modern research platform inclusive of a comprehensive clinical research program with exemplary data management and clinical trial prioritization as well as scientific oversight and leadership. The UWCCC NCTN LAPs multi-disciplinary team remains an integral component of this strategic initiative and collaborates with key faculty to support innovative translational research for next generation clinical trials within the NCI's National Clinical Trials Network. Since 1974, UWCCC faculty have functioned as leaders in the development of the NCI cancer cooperative group program; first within ECOG and then with RTOG, ACOSOG and GOG in the early 2000s. As the NCI and its NCTN transitioned to a centralized infrastructure in 2014, the UWCCC designed a LAPS team of collaborative principal investigators by combining the existing broad scientific leadership from three of the primary cooperative groups (ECOG/ACRIN, NRG and ALLIANCE). This multi-disciplinary approach with leaders from Surgical, Medical, Radiation and Gynecologic Oncology, facilitated an innovative governance structure to provide leadership and oversight in prioritization of Phase II/III clinical trials, timely trial activation and robust accrual as well as the development of junior faculty interested in oncologic clinical research. In the four years since our last grant submission, the UWCCC LAPS team has provided support for the important genomically-directed clinical trials as well as those with a focus on advanced imaging, while strengthening our Cancer Center's infrastructure. This UG1 application seeks support for continuing the NCTN activities within the UWCCC. This partnership remains an important mechanism for providing a diverse population of cancer patients with novel treatment approaches, as well as a means for providing resources and support for existing and new leaders within the NCTN to bring innovative translational projects to Phase II/III clinical trials.

项目概要/摘要 威斯康星大学卡本癌症​​中心 (UWCCC) 及其领导层和教职员工均受到 使命是通过在癌症教育、预防方面快速应用突破性研究来战胜癌症 和治疗。 UWCCC 的战略计划中包含了扩展现代研究平台的策略 包括具有示范性数据管理和临床试验的综合临床研究计划 优先顺序以及科学监督和领导。 UWCCC NCTN LAPs 多学科团队 仍然是这一战略举措不可或缺的组成部分，并与主要教师合作支持创新 NCI 国家临床试验网络内下一代临床试验的转化研究。 自 1974 年以来，UWCCC 教师一直在 NCI 癌症合作小组的发展中发挥领导作用 程序;首先是在 ECOG 内，然后在 2000 年代初与 RTOG、ACOSOG 和 GOG 合作。作为 NCI 及其 NCTN 于 2014 年过渡到集中式基础设施，UWCCC 设计了一个 LAPS 协作团队 主要研究者通过结合三个主要合作社现有的广泛科学领导力 团体（ECOG/ACRIN、NRG 和 ALLIANCE）。这种多学科方法与来自外科、 医疗、放射和妇科肿瘤学促进了创新的治理结构，以提供 领导和监督 II/III 期临床试验的优先顺序、及时的试验激活和稳健的应计费用 以及对肿瘤临床研究感兴趣的初级教师的发展。自从我们上次见面以来的四年里 提交拨款后，UWCCC LAPS 团队为重要的基因组定向临床提供了支持 试验以及重点关注先进成像的试验，同时加强我们的癌症中心的基础设施。 此 UG1 申请寻求支持以继续在 UWCCC 内开展 NCTN 活动。此次合作 仍然是为不同人群的癌症患者提供新治疗的重要机制 方法以及为现有和新领导者提供资源和支持的手段 NCTN 将创新转化项目引入 II/III 期临床试验。