Center for Redox Biology and Cardiovascular Disease

氧化还原生物学和心血管疾病中心

基本信息

批准号：
9763036
负责人：
Christopher G Kevil
金额：
$ 26.34万
依托单位：
LOUISIANA STATE UNIV HSC SHREVEPORT
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-01 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9763036
关键词：
Achievement Address Advisory Committees Americas Animal Model Annual Reports Antioxidants Area Award Biology Blood Vessels Cardiac Cardiovascular Diseases Cardiovascular Pathology Cardiovascular system Categories Cause of Death Centers of Research Excellence Cessation of life Core Facility Country Development Disease Ensure Environment Equilibrium Faculty Functional disorder Funding Future Goals Grant Growth Health Health Sciences Heart Diseases Histology Individual Institution Knowledge Lead Leadership Louisiana Mentors Mentorship Molecular Molecular Biology Morbidity - disease rate Oxidation-Reduction Oxidative Stress Play Policies Process Program Development Regulation Reporting Research Research Infrastructure Research Personnel Research Training Role Science Scientific Advances and Accomplishments Signal Transduction Time Training Training Programs United States Vascular Diseases base cardiovascular health disability education research faculty research insight meetings molecular pathology mortality programs recruit response

项目摘要

Project Abstract Cardiovascular disease is the leading cause of death and disability in the United States with a disproportional effect on southern regions of the country. According to the 2016 America's Health Rankings Annual Report, Louisiana ranks 46/50 in cardiovascular deaths and 48/50 in heart disease placing it in the lowest categories of cardiovascular health across the nation. Moreover, for the first time in 27 years, the rate of cardiovascular deaths increased across the nation highlighting the magnitude and importance of cardiovascular research. While advances in cardiovascular treatments have been realized, many cardiovascular disease mechanisms remain poorly understood. It has become clear that changes in heart and vascular oxidative stress and antioxidant defenses, the so called `redox balance', plays critical roles in disease initiation and propagation. However, specific ways that alterations in redox biology control cellular and molecular responses leading to cardiovascular disease remains largely unknown. The Center for Cardiovascular Diseases and Sciences at LSU Health Sciences Center Shreveport has assembled investigators with state of the art knowledge and research expertise across several departments to address redox biology molecular mechanisms contributing to cardiovascular pathophysiology. The intent of this proposal is to develop and establish a COBRE Center for Redox Biology and Cardiovascular Disease with a nationally recognized enriched training environment for junior faculty that advances the competitiveness of research programs for national awards. Individual primary projects have been carefully chosen based on their relevance to the research theme, novelty of the research topic regarding redox biology and cardiovascular disease, and their potential ability to achieve program independence. The proposed projects will provide new understanding of redox biology mechanisms required for cardiac and vascular (dys)function with support from advanced, state of the art animal models and redox molecular pathology research core facilities. Research and professional development programs are also proposed that will provide continued growth and leadership in this area.

项目摘要心血管疾病是美国死亡和残疾的主要原因，其发病率不成比例。对该国南部地区的影响。根据2016年美国健康排名年度报告，路易斯安那州在心血管死亡方面排名为 46/50，在心脏病方面排名为 48/50，使其处于最低类别全国心血管健康。此外，27 年来首次，心血管疾病发病率全国范围内的死亡人数增加，凸显了心血管研究的规模和重要性。尽管心血管治疗已取得进展，但许多心血管疾病机制仍然知之甚少。很明显，心脏和血管氧化应激的变化以及抗氧化防御，即所谓的“氧化还原平衡”，在疾病的发生和传播中发挥着关键作用。然而，氧化还原生物学改变控制细胞和分子反应的特定方式导致心血管疾病在很大程度上仍然未知。心血管疾病和科学中心路易斯安那州立大学什里夫波特健康科学中心聚集了具有最先进知识和能力的研究人员跨多个部门的研究专业知识，解决氧化还原生物学分子机制，有助于心血管病理生理学。该提案的目的是开发和建立 COBRE 中心氧化还原生物学和心血管疾病，拥有国家认可的丰富培训环境提高国家奖项研究项目竞争力的初级教师。个人小学项目是根据其与研究主题的相关性、研究的新颖性精心选择的关于氧化还原生物学和心血管疾病及其实现计划的潜在能力的主题独立。拟议的项目将为所需的氧化还原生物学机制提供新的理解在先进、最先进的动物模型和氧化还原的支持下，针对心脏和血管（功能障碍）功能分子病理学研究核心设施。研究和专业发展计划也提议将在该领域提供持续增长和领导地位。