SOCIAL RELATIONS, AGING, AND CARDIOVASCULAR CHANGES

社会关系、衰老和心血管变化

• 批准号: 2327083
• 负责人: Bert N. Uchino
• 金额: $ 10万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-19 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2327083
• 关键词: age difference; aging; cardiovascular function; clinical research; disease /disorder proneness /risk; human subject; physiologic stressor; psychological stressor; social psychology; social support network

THIS IS A SHANNON AWARD PROVIDING PARTIAL SUPPORT FOR THE RESEARCH PROJECTS THAT FALL SHORT OF THE ASSIGNED INSTITUTE'S FUNDING RANGE BUT ARE IN THE MARGIN OF EXCELLENCE. THE SHANNON AWARD IS INTENDED TO PROVIDE SUPPORT TO TEST THE FEASIBILITY OF THE APPROACH; DEVELOP FURTHER TESTS AND REFINE RESEARCH TECHNIQUES; PERFORM SECONDARY ANALYSIS OR AVAILABLE DATA SETS; OR CONDUCT DISCRETE PROJECTS THAT CAN DEMONSTRATE THE PI'S RESEARCH CAPABILITIES OR LEND ADDITIONAL WEIGHT TO AN ALREADY MERITORIOUS APPLICATION. THE ABSTRACT BELOW IS TAKEN FROM THE ORIGINAL DOCUMENT SUBMITTED BY THE PRINCIPAL INVESTIGATOR. DESCRIPTION: Aging is typically associated with significant changes in cardiovascular function (e.g., increased blood pressure) that confer increased vulnerability to physical health problems. Research on chronological age and physiological function, however, suggests that physiological and chronological age are not isomorphic, and that social factors may play a role in the aging process. This application proposes to study the cardiovascular responses to laboratory stressors longitudinally for 144 men and women between the ages of 30 to 70. One aim of the proposal is to examine the influence of age on detailed invasive measures of resting cardiovascular function including systolic blood pressure, diastolic blood pressure, heart rate, systolic time intervals, cardiac output, and total peripheral resistance. Although age-related differences in standard resting measures of cardiovascular function (e.g., heart rate, blood pressure) are well-documented, much less is known about the influence of age on cardiovascular responses to psychological stressors. Therefore, a second aim of this research is to examine age-related differences and changes in cardiovascular reactivity during acute psychological stress. A third, and major aim of this research, is to examine a general conceptual model of the influence of positive and negative aspects of social relationships (e.g., social support, social conflict, social ambivalence) on such age-related differences and changes in resting cardiovascular activity and cardiovascular reactivity during acute psychological stress. Based on the proposed conceptual model, these investigators will also examine more specific psychological and behavioral factors that may be mediating these relationships.

这是香农奖，为研究提供部分支持 与指定研究所的资金范围相差的项目，但 处于卓越的范围。香农奖旨在提供 支持测试方法的可行性；开发进一步的测试 并完善研究技术；进行次要分析或可用 数据集；或执行可以证明PI的离散项目 研究能力或增加本来有功的重量 应用。下面的摘要取自原始文档 由首席调查员提交。 描述：衰老通常与重大变化有关 赋予的心血管功能（例如，血压升高） 增加了对身体健康问题的脆弱性。 研究 然而，年代年龄和生理功能表明 生理年龄和年龄不是同构，而社会 因素可能在衰老过程中起作用。 此申请提出 研究对实验室压力源的心血管反应 144名30至70岁之间的男女纵向。 该提案的目的是检查年龄对详细的影响 静止心血管功能的侵入性测量包括收缩期 血压，舒张压，心率，收缩期时间 间隔，心脏输出和总周围电阻。 虽然 与年龄有关的标准静止措施的差异 功能（例如，心率，血压）有充分记录，很多 关于年龄对心血管响应的影响少知道 心理压力源。 因此，这项研究的第二个目的是 检查与年龄有关的差异和心血管变化 急性心理压力期间的反应性。 三分之一，也是主要目的 这项研究是为了检查影响的一般概念模型 社会关系的积极和消极方面（例如，社会 支持，社会冲突，社会矛盾） 静止心血管活动的差异和变化 急性心理压力期间的心血管反应性。 基于 提出的概念模型，这些研究者还将检查更多 可能正在介导的特定心理和行为因素 这些关系。

项目成果

Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients.

• DOI: 10.1186/s13024-017-0217-5
• 发表时间: 2017-10-24
• 期刊: Molecular neurodegeneration
• 影响因子: 15.1
• 作者: Konrad C;Kawamata H;Bredvik KG;Arreguin AJ;Cajamarca SA;Hupf JC;Ravits JM;Miller TM;Maragakis NJ;Hales CM;Glass JD;Gross S;Mitsumoto H;Manfredi G
• 通讯作者: Manfredi G

Age-related differences in cardiovascular reactivity during acute psychological stress in men and women.

男性和女性急性心理应激期间心血管反应性的年龄相关差异。

• DOI: 10.1093/geronb/54b.6.p339
• 发表时间: 1999
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Uchino,BN;Uno,D;Holt-Lunstad,J;Flinders,JB
• 通讯作者: Flinders,JB