Oklahoma Center for Respiratory and Infectious Diseases

俄克拉荷马州呼吸和传染病中心

基本信息

批准号：
10215542
负责人：
LIN LIU
金额：
$ 223.38万
依托单位：
OKLAHOMA STATE UNIVERSITY STILLWATER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10215542
关键词：
Acquired Immunodeficiency Syndrome Address Affect Animal Model Applications Grants Area Award Centers of Research Excellence Collaborations Communicable Diseases Communities Core Facility Development Disease Faculty Financial Support Foundations Funding Goals Grant Health Sciences Infectious Diseases Research Influenza Institutes Institution Journals Leadership Lung diseases Lung infections Malignant Neoplasms Medical Research Medicine Mentors Mentorship Modernization Molecular Biology Nature Oklahoma Paper Phase Pilot Projects Pneumonia Population Positioning Attribute Program Research Project Grants Pseudomonas aeruginosa Publishing Research Research Infrastructure Research Institute Research Personnel Research Project Grants Research Training Respiratory Center Respiratory Tract Infections Scientist Series Services Streptococcus pneumoniae Talents Technology United States National Institutes of Health Universities Viral bench to bedside burden of illness college combat drug development immunopathology improved influenzavirus innovation inter-institutional interdisciplinary collaboration meetings member multidisciplinary new technology prevent programs public health priorities recruit respiratory success tenure track

项目摘要

PROJECT SUMMARY This CoBRE Phase II application seeks support to further develop the multi-institute Oklahoma Center for Respiratory and Infectious Diseases (OCRID) into a sustainable center of research excellence. Established in 2013 through the Phase I CoBRE grant, OCRID is quickly becoming a focal point for expanding respiratory infectious disease research in Oklahoma. OCRID investigators come from major research institutions across the state of Oklahoma, including 10 colleges at Oklahoma State University (OSU) and the University of Oklahoma (OU), as well as an independent research institute, the Oklahoma Medical Research Foundation (OMRF). OCRID is unified by a commitment to excellence in research and training in respiratory and infectious diseases. Our scientists and leadership cultivate excellence through deliberate faculty mentorship, robust interdisciplinary collaboration, innovative research, and a dynamic bench-to-bedside-to-marketplace approach. As the first CoBRE grant ever received by OSU, the Phase I award has made a transformative change in the research landscape on respiratory infectious disease research in Oklahoma. Building on the success of the Phase I award, the overall objective of this Phase II CoBRE application is to build a sustainable research center of excellence in the field of respiratory and infectious diseases. Of the four Phase II research projects on respiratory infectious diseases in this application led by four talented and promising junior investigators, two focus on influenza virus, one on Streptococcus pneumonia and one on Pseudomonas aeruginosa. Aim 1 will expand the critical mass of multi-disciplinary investigators in the thematic area of respiratory infectious diseases. This aim will be accomplished by 1) mentoring four Phase II project leaders to become NIH-funded independent investigators; 2) hiring at least 4 new tenure-track faculty members whose research is within the focus of the Center; 3) nurturing junior investigators and re-directing established investigators into respiratory infectious disease research via a pilot project program; and 4) recruiting and mentoring replacement project leaders after the current Phase II project leaders rotate out after the initial 2-3 years of support. Aim 2 will further develop the research infrastructure by strengthening three unique research cores (Animal Models, Immunopathology, and Molecular Biology). Aim 3 will enhance inter-institutional collaborations in Oklahoma to develop a self-sustainable respiratory and infectious research center. The further development of OCRID via this Phase II CoBRE will have even greater positive impact on respiratory and infectious disease research in the state of Oklahoma and will sustain the only Center of its kind in Oklahoma.

项目概要该 CoBRE 二期申请寻求支持，以进一步发展多机构俄克拉荷马中心呼吸和传染病 (OCRID) 成为可持续的卓越研究中心。已确立的 2013 年，通过第一阶段 CoBRE 资助，OCRID 迅速成为扩大呼吸系统疾病的焦点俄克拉荷马州的传染病研究。 OCRID 调查人员来自世界各地主要研究机构俄克拉荷马州，包括俄克拉荷马州立大学 (OSU) 和俄克拉荷马大学的 10 所学院俄克拉荷马州 (OU) 以及独立研究机构俄克拉荷马州医学研究基金会（OMRF）。 OCRID 致力于呼吸道和传染病领域的卓越研究和培训疾病。我们的科学家和领导层通过刻意的教师指导、强有力的指导来培养卓越的人才跨学科合作、创新研究以及动态的从实验室到临床到市场的方法。作为 OSU 收到的第一个 CoBRE 资助，第一阶段资助在俄克拉荷马州呼吸道传染病研究的研究概况。建立在成功的基础上第一阶段奖励，第二阶段 CoBRE 应用的总体目标是建立可持续的研究呼吸系统疾病和传染病领域的卓越中心。四个二期研究项目中本申请中的呼吸道传染病由四名才华横溢且有前途的初级研究人员领导，其中两名重点关注流感病毒，一项关注肺炎链球菌，一项关注铜绿假单胞菌。目标1将扩大呼吸道传染病专题领域多学科研究人员的临界数量疾病。这一目标将通过以下方式实现：1）指导四名第二阶段项目负责人成为 NIH 资助的人独立调查员； 2) 聘用至少 4 名新的终身教职人员，其研究属于中心的重点； 3）培养初级研究人员并将已建立的研究人员重新引导到呼吸系统通过试点项目进行传染病研究； 4) 招募和指导替代项目当前第二阶段项目领导者在最初 2-3 年的支持后轮流退出。目标2将通过加强三个独特的研究核心（动物模型、免疫病理学和分子生物学）。目标 3 将加强俄克拉荷马州的机构间合作，建立一个自我可持续的呼吸道和传染病研究中心。 OCRID 的进一步发展第二阶段 CoBRE 将对呼吸道和传染病研究产生更大的积极影响俄克拉荷马州并将维持俄克拉荷马州唯一的此类中心。