Akt Kinase Signalling, Regulated Vesicular Transport and Lipid Metabolism

Akt 激酶信号传导、调节囊泡运输和脂质代谢

• 批准号: nhmrc : 568619
• 负责人: Dr Valerie Wasinger
• 金额: $ 22.53万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/akt-kinase-signalling-lipid-metabolism/77951
• 关键词: Akt; Kinase; Signalling; Regulated; Vesicular

How do metabolic cues tell cancer cells to make more membranes, or fat cells to make more fat? These are some of the questions that underpin this project, which explores the link between cell signalling, protein trafficking and fat metabolism. Specifically, we aim to define the role of an important signalling molecule (Akt) in intracellular transport and activation of a key integrator of fat metabolism (SREBP). This work will have wide-ranging implications for human health and disease.

代谢信号如何告诉癌细胞制造更多的细胞膜，或告诉脂肪细胞制造更多的脂肪？这些是支撑该项目的一些问题，该项目探讨了细胞信号传导、蛋白质运输和脂肪代谢之间的联系。具体来说，我们的目标是确定重要信号分子 (Akt) 在细胞内转运和脂肪代谢关键整合因子 (SREBP) 激活中的作用。这项工作将对人类健康和疾病产生广泛的影响。