Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers

为接受放疗的肺癌患者及其家人提供的二元瑜伽课程

基本信息

批准号：
10214568
负责人：
Kathrin Milbury
金额：
$ 12.64万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-09 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10214568
关键词：
Address Adult Children Affect Behavior Therapy Behavioral Behavioral Sciences Biological Markers Blood specimen Cancer Patient Caregivers Caring Data Disease Distress Dose Dyspnea Education Effectiveness Emotional Endocrine Evidence based intervention Family Family Caregiver Fatigue Future Goals Health education Hydrocortisone Immune Inflammatory Intervention Intervention Studies Investigation Knowledge Light Link Literature Lung diseases Malignant Neoplasms Malignant neoplasm of lung Measures Mediating Mediator of activation protein Meditation Mental Depression Modeling Nature Non-Small-Cell Lung Carcinoma Outcome Participant Patients Performance Periodicity Physical Function Physical Performance Population Prognostic Factor Qualitative Methods Quality of Care Quality of life Radiation therapy Randomized Randomized Controlled Trials Rehabilitation therapy Reporting Research SF-36 Sampling Scientific Advances and Accomplishments Siblings Sleep disturbances Source Spouses Subgroup Supportive care Symptoms Taxes Testing Treatment Efficacy United States Vulnerable Populations Walking Woman Work Yoga arm attentional control base body-mind cancer therapy cancer type caregiving clinical care clinically relevant clinically significant common symptom comparison group cytokine depressive symptoms design efficacy trial evidence base experience follow up assessment improved informal caregiving innovation intervention effect malignant breast neoplasm men patient population physical symptom primary outcome programs psychologic psychological distress psychological symptom pulmonary function saliva sample secondary outcome skills survival prediction symptom management symptomatic improvement treatment duration treatment optimization treatment planning treatment response trial comparing usual care arm

项目摘要

PROJECT SUMMARY/ABSTRACT Patients with lung cancer, the most prevalent cancer in United States affecting both men and women, experience more debilitating physical and psychological symptoms than patients with other types of cancer. Common symptoms include reduced lung function, dyspnea, fatigue, sleep disturbances, and depression compromising their quality of life (QOL). In light of these symptoms, patients have a high need for care and support. Patients’ family caregivers are their most important and valued source of support and care; yet, caregiving is physically and emotionally taxing. In fact, family caregivers report high rates of psychological distress, fatigue, and sleep disturbances, which may compromise the quality of care they are able to provide to the patient. Given the interdependent nature of QOL in families, poor caregiver QOL may undermine patient QOL. Therefore, there is a need to established evidence-based dyadic supportive care programs targeting both patient and caregiver outcomes. Based on the promising findings of our pilot data, we proposed to examine a dyadic yoga program in patients with lung cancer (LC) and their family caregivers. To determine efficacy of a yoga program, the proposed research will randomly assign patient-caregiver dyads to either a dyadic yoga or a dyadic education group. Prior to randomization, both patients and caregivers will complete standard QOL measures. We will also collect biomarkers from blood and saliva samples. Patients will complete objective measures of physical performance. Based on their group assignment, dyads will either attend yoga sessions or health education sessions together. Both groups will receive the same intervention exposure (15 sessions, 60 min each) over the course of patients’ 6-week radiation treatment (RT) plans. During the treatment period, we will weekly assess patients’ symptoms. At the end of RT, 1, 2, 3, and 6-months later, dyads in both groups will be re-assessed. At the 3-month follow-up assessment, we will also collect qualitative samples to further understand participants’ experiences. The primary goal of this research is to demonstrate that, in the yoga group, patients will show better objective physical performance both patients and caregivers will report greater improvements in QOL compared to those in the dyadic education group. Secondary goals are to examine improvements in symptom burden, endocrine and immune dysregulation and symptom management and if these improvements mediate the physical function and QOL outcomes. Lastly, we examine factors that may moderate interventions effects, which will inform future studies expanding this program of research. This project represents a major step towards managing physical performance and QOL in lung cancer patients and their caregivers, a vulnerable yet understudied population.

项目概要/摘要肺癌是美国最常见的癌症，影响男性和女性，患者经历过与其他类型的癌症患者相比，患者会出现更严重的身体和心理症状。症状包括肺功能下降、呼吸困难、疲劳、睡眠障碍和抑郁症鉴于这些症状，患者非常需要护理和支持。家庭照顾者是他们最重要和最有价值的支持和照顾来源，但照顾是身体上的；事实上，家庭护理人员报告的心理困扰、疲劳和睡眠问题的比例很高。干扰，这可能会影响他们为患者提供的护理质量。家庭生活质量具有相互依存的性质，护理人员生活质量不佳可能会损害患者的生活质量。需要建立针对患者和护理人员的基于证据的二元支持性护理计划基于我们的试点数据的有希望的结果，我们建议研究二元瑜伽计划。肺癌 (LC) 患者及其家庭护理人员为了确定瑜伽项目的效果，拟议的研究将随机分配患者-护理人员二人组进行二元瑜伽或二元教育在随机分组之前，患者和护理人员都将完成标准的生活质量测量。从血液和唾液样本中收集生物标记物，患者将完成客观的身体测量。根据他们的小组作业，两人将参加瑜伽课程或健康教育。两组将同时接受相同的干预（15 次，每次 60 分钟）。患者的 6 周放射治疗 (RT) 计划的疗程在治疗期间，我们将每周进行评估。在 RT 结束、1、2、3 和 6 个月后，将重新评估两组患者的症状。在为期3个月的跟踪评估中，我们还将收集定性样本，以进一步了解参与者的这项研究的主要目标是证明，在瑜伽组中，患者会表现出体验。患者和护理人员的客观身体表现更好，生活质量将得到更大改善与二元教育组相比，次要目标是检查症状的改善。负担、内分泌和免疫失调以及症状管理，以及这些改善是否介导最后，我们研究了可能调节干预效果的因素，这将为扩展该研究计划的未来研究提供信息。该项目代表了朝着这一目标迈出的重要一步。管理肺癌患者及其护理人员的身体表现和生活质量，这是一个脆弱的群体未被充分研究的人群。