University of North Carolina Womens Interagency HIV Study UNC WIHS

北卡罗来纳大学妇女机构间艾滋病毒研究 UNC WIHS

基本信息

批准号：
9205484
负责人：
ADAORA A ADIMORA
金额：
$ 201.87万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-10 至 2019-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9205484
关键词：
Acquired Immunodeficiency Syndrome Address Affect Affordable Care Act Age Aging Atlases Biostatistical Methods Blood Cancer Biology Caring Cervical dysplasia Clinic Cohort Studies Collaborations Communicable Diseases Complement Comprehensive Cancer Center Data Disease Enrollment Epidemic Epidemiologic Methods Epidemiology Female Genome Geographic Locations HIV HIV Infections HIV Seropositivity Health Health Insurance Health Services Research Healthcare Heart High Risk Woman Human Genome Human Papillomavirus Immune Immunologic Surveillance Immunologics Income Individual Inequality Infection Inflammation Insurance Coverage Interdisciplinary Study International Intervention Investigation Lead Lesion Malignant Neoplasms Malignant neoplasm of cervix uteri Menopause Methods Microbial Genetics Midwestern United States Molecular Biology Neighborhoods North Carolina Outcome Pathogenesis Pathway interactions Physiological Plasma Policies Population Postmenopause Poverty Premalignant Prevention Recruitment Activity Research Research Personnel Risk Role Rural Sampling Science Screening for cancer Serum Site Statistical Methods Statutes and Laws Target Populations The Cancer Genome Atlas Time Tissues To specify United States National Institutes of Health Universities Viral Woman Women’s Interagency HIV Study base blood pressure regulation cancer therapy cohort contextual factors cytokine experience follow-up genome-wide analysis health care availability high risk improved innovation malignant breast neoplasm men multidisciplinary multilevel analysis novel programs prospective public health relevance reproductive tract social socioeconomics trafficking tumor progression tumorigenesis vaginal microbiome virology virus genetics virus host interaction

项目摘要

DESCRIPTION (provided by applicant): This application proposes to establish The University of North Carolina at Chapel Hill as a new site for the Women's Interagency HIV Study (WIHS). The proposal represents a collaborative effort between investigators from The UNC Center for Infectious Diseases, Center for AIDS Research, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research. We propose to rapidly establish the UNC-WIHS cohort, contribute meaningfully to the national WIHS scientific program, and undertake an ambitious HIV research agenda that encompasses social epidemiology and health outcomes, advanced epidemiologic and biostatistical methods, pathogenesis, and molecular biology of cancer. We aim to: 1) Recruit and retain in follow-up a cohort of 200 HIV+ and 100 HIV- women who are at high risk for HIV infection and represent NC's HIV epidemic, thus expanding the WIHS Cohort to women who live in a region at the forefront of the US epidemic; 2) Characterize the relationship between socioeconomic context, changes in access to health insurance, and health outcomes among HIV+ and HIV- women; 3) Develop and apply novel epidemiologic and statistical methods using data from the UNC-WIHS and the entire WIHS cohort; 4) Characterize HIV persistence in the blood and genital tract among pre- and post-menopausal women; and 5) Investigate the pathobiology of breast and cervical cancers to identify immunological, microbial and genetic factors that affect cancer progression and treatment in HIV positive women. By contributing a diverse and complementary population of women, innovative science, and a strong, multidisciplinary cadre of investigators, UNC will enhance the efforts of the WIHS, expand the range of questions that can be addressed and, in collaboration with the entire group, improve the health of HIV+ women and women at high risk for HIV infection.

描述（由申请人提供）：本申请提议建立北卡罗来纳大学教堂山分校作为妇女机构间艾滋病毒研究 (WIHS) 的新地点。该提案代表了北卡罗来纳大学传染病中心、艾滋病研究中心、莱恩伯格综合癌症中心和塞西尔·G·谢普斯健康服务研究中心的研究人员之间的合作努力。我们建议迅速建立 UNC-WIHS 队列，为国家 WIHS 科学计划做出有意义的贡献，并开展一项雄心勃勃的艾滋病毒研究议程，其中包括社会流行病学和健康结果、先进的流行病学和生物统计方法、发病机制和癌症分子生物学。我们的目标是： 1) 招募并保留 200 名 HIV+ 和 100 名 HIV- 女性，她们是 HIV 感染高危人群，代表北卡罗来纳州的 HIV 流行情况，从而将 WIHS 队列扩大到居住在以下地区的女性：美国疫情最前线； 2) 描述艾滋病病毒感染者和艾滋病毒感染者的社会经济背景、获得医疗保险的变化以及健康结果之间的关系； 3) 利用 UNC-WIHS 和整个 WIHS 队列的数据开发和应用新的流行病学和统计方法； 4) 描述绝经前和绝经后妇女血液和生殖道中艾滋病毒持续存在的特征； 5) 研究乳腺癌和宫颈癌的病理学，以确定影响艾滋病毒阳性女性癌症进展和治疗的免疫、微生物和遗传因素。通过贡献多样化和互补的女性群体、创新科学以及强大的多学科研究人员队伍，北卡罗来纳大学将加强 WIHS 的工作，扩大可以解决的问题范围，并与整个小组合作，改进HIV 阳性妇女和 HIV 感染高危妇女的健康。