Mediators of fibrosis in the development of lower urinary tract dysfunction

下尿路功能障碍发展中纤维化的介质

• 批准号: 9353662
• 负责人: WILLIAM A RICKE
• 金额: $ 120万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-24 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9353662
• 关键词: Address; Automobile Driving; Basic Science; Benign; Benign Prostatic Hypertrophy; Biological; Biomedical Research; Clinical Research; Communities; Databases; Development; Fibrosis; Functional disorder; Future; Goals; Histology; Hormonal; Inflammatory; Lower urinary tract; Mediator of activation protein; Metabolic; Modeling; Molecular; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Patient Selection; Patients; Physiological; Process; Prostate; Prostatic; Prostatic Diseases; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Testing; Tissues; Training; Urology; lower urinary tract symptoms; meetings; men; next generation; programs; public health relevance; targeted treatment; urinary; urologic

DESCRIPTION (provided by applicant): The Specific Aims of the UW-Madison George M. O'Brien Urology Cooperative Research Center are: 1. To investigate molecular and cellular biological mechanisms driving fibrosis in the prostates of mice and men; and 2. To investigate the relationship of hormonal, developmental, metabolic, and inflammatory processes in development of fibrosis associated with lower urinary tract dysfunction tract using functional urological testing. Fibrosis is commonly observed in the prostates of men with Benign Prostatic Hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS). Fundamental causes of prostatic fibrosis and the relationship of prostatic fibrosis to LUTS remain unclear. The overall goals of this Center are to critically investigate fundamental mechanisms that underlie development of prostatic fibrosis and to determine the relationship between benign prostatic disease and lower urinary tract dysfunction. Our center consists of four research projects, and each incorporates unique models of benign prostatic disease in mice and analysis of tissues from BPH patients to address the objectives of the Center. The Administrative Core will provide oversight and alignment of projects. The Administrative Core will also manage the Educational Enrichment Program and Opportunity Pool. The Biomedical Research Core will provide project leaders and other investigators with the resources in mouse urinary function testing and histology to achieve the goals of the research. The Biomedical Core, in cooperation with the NIDDK and other groups, will also develop a robust database to make results and pertinent information generated by the Center and elsewhere readily accessible. This is a new venture and one that is of substantial importance to the urological research community. The long-range goal is to achieve an individualized and mechanistic understanding of LUTS pathophysiology and thereby refine patient selection for existing therapies. We will leverage our extensive institutional resources to develop an outstanding educational enrichment program that incorporates new researchers from all levels into urologic research. By meeting these objectives, this Center will make significant progress toward understanding mechanisms underlying LUTS, resulting in new mechanistically-targeted therapeutic options.

描述（由申请人提供）： 威斯康星大学麦迪逊分校 George M. O'Brien 泌尿学合作研究中心的具体目标是： 1. 研究驱动小鼠和男性前列腺纤维化的分子和细胞生物学机制； 2. 使用功能泌尿学测试研究与下尿路功能障碍相关的纤维化发展中激素、发育、代谢和炎症过程的关系。纤维化常见于患有良性前列腺增生 (BPH) 和下尿路症状 (LUTS) 的男性前列腺。前列腺纤维化的根本原因以及前列腺纤维化与 LUTS 的关系仍不清楚。该中心的总体目标是严格研究前列腺纤维化发展的基本机制，并确定良性前列腺疾病与下尿路功能障碍之间的关系。我们的中心由四个研究项目组成，每个项目都包含独特的小鼠良性前列腺疾病模型和对 BPH 患者组织的分析，以实现该中心的目标。行政核心将提供项目的监督和调整。行政核心还将管理教育丰富计划和机会池。生物医学研究核心将为项目负责人和其他研究人员提供小鼠泌尿功能测试和组织学方面的资源，以实现研究目标。生物医学核心还将与 NIDDK 和其他团体合作开发一个强大的数据库，以使该中心和其他地方生成的结果和相关信息易于获取。这是一项新的尝试，对泌尿外科研究界具有重要意义。长期目标是实现对 LUTS 病理生理学的个体化和机制性理解，从而优化现有疗法的患者选择。我们将利用我们广泛的机构资源来开发出色的教育丰富计划，将各个级别的新研究人员纳入泌尿学研究。通过实现这些目标，该中心将在理解 LUTS 的机制方面取得重大进展，从而产生新的机制靶向治疗方案。