MECHANISMS OF ISCHEMIC STROKE

缺血性中风的机制

• 批准号: 2431211
• 负责人: MARK J FISHER
• 金额: $ 108.37万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2431211
• 关键词: cerebral ischemia /hypoxia; stroke; vascular endothelium

This proposal is for a multi-disciplinary stroke program that will focus on defining processes that appear to be of critical importance in the initiation of ischemic stroke. The aim of the program is to delineate the relationship between stroke, stroke risk factors, and hemostasis regulation of the brain and will utilize clinical, animal, and cell culture studies. Project 1 is a case-control study, the purpose of which is to define the relationship between ischemic stroke, stroke risk factors, infectious and inflammatory processes, and hemostasis function. Project 2 studies the interaction of stroke risk factors, endotoxin exposure, and extracranial artery occlusion on brain hemostasis regulation in the rat model. Project 3 investigates brain capillary hemostasis at a cellular and molecular level by studies of CNS-derived human brain endothelium; the emphasis is on the effects of plasma factors associated with stroke risk factors and the impact of inflammatory cytokines on CNS- derived endothelial hemostasis function. The projects are linked by a common focus of interests, and studies performed by the laboratories of each project that directly assist with the specific aims of other projects. Completion of this program will substantially enhance our knowledge of processes relevant to ischemic stroke pathogenesis leading to new strategies for stroke prevention.

该提案针对多学科卒中计划，该计划将重点关注 定义在以下方面至关重要的流程： 缺血性中风的起始。 该计划的目的是描绘 中风、中风危险因素和止血之间的关系 大脑的调节并将利用临床、动物和细胞 文化研究。 项目1是一项病例对照研究，其目的 是为了定义缺血性中风与中风风险之间的关系 因素、感染和炎症过程以及止血功能。 项目 2 研究中风危险因素、内毒素的相互作用 暴露和颅外动脉闭塞对脑止血调节的影响 在大鼠模型中。 项目 3 研究脑毛细血管止血 通过对中枢神经系统衍生的人脑进行细胞和分子水平的研究 内皮细胞；重点是相关血浆因素的影响 中风危险因素以及炎性细胞因子对中枢神经系统的影响 衍生内皮止血功能。这些项目通过一个 共同的兴趣焦点以及实验室进行的研究 每个项目都直接协助其他项目的具体目标 项目。 该计划的完成将大大提高我们的 了解与缺血性中风发病机制相关的过程，导致 预防中风的新策略。