Howard University Research Center for Minority Health and Health Disparities

霍华德大学少数族裔健康与健康差异研究中心

• 批准号: 10874292
• 负责人: William M. Southerland
• 金额: $ 22.09万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2024-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10874292
• 关键词: ATP phosphohydrolase; Accounting; Acquired Immunodeficiency Syndrome; Adolescence; Adolescent; Affect; Africa South of the Sahara; African; African American; Anatomy; Anti-Retroviral Agents; Antiviral Therapy; Apoptosis; Apoptotic; Biological Markers; Birth; Black race; Breast Feeding; C-reactive protein; Calcitonin Gene-Related Peptide; Calcium; Cardiac; Cardiac Myocytes; Cardiovascular Abnormalities; Cardiovascular Diseases; Cardiovascular system; Caring; Cell Hypoxia; Cell physiology; Cells; Cesarean section; Cessation of life; Child; Chronic; Chronic Disease; Clinical; Clinical Data; Country; Cytomegalovirus; Data; Development; Economic Factors; Effectiveness; Expectancy; Exposure to; FREQ gene; Female; Fetus; Functional disorder; Fura-2; Future; Gene Expression; Goals; Growth; HIV; HIV Infections; HIV diagnosis; HIV risk; HIV-exposed uninfected infant; HIV/AIDS; Health; Heart; Heart Abnormalities; Hispanic; Hormonal; Hospitalization; Human Milk; Hypertension; Image; Immune; Impairment; Incidence; Individual; Infant; Inflammation; Inflammatory; Inositol; Insulin-Like Growth Factor I; Intake; Investigation; Latina; Left; Life Expectancy; Life Style; Longevity; MAPK Signaling Pathway Pathway; Maternal-Fetal Transmission; Measures; Medical; Metabolism; Minerals; Minority Groups; Mitochondria; Mother-to-child HIV transmission; Mothers; Myocardial; Myocardial dysfunction; Myocarditis; Neonatal; Newborn Infant; Newly Diagnosed; Nuclear; Outcome; Oxidative Regulation; Oxidative Stress; PIK3CG gene; Pathway interactions; Peptides; Perinatal; Perinatal Infection; Persons; Pharmaceutical Preparations; Population; Potassium; Pregnancy; Pregnant Women; Prevention; Probability; Process; Public Health; Pump; Quality of life; Rattus; Recommendation; Recovery; Regimen; Regulation; Relaxation; Reporting; Research; Residual state; Rest; Risk; Rodent; Rodent Model; Role; Ryanodine Receptor Calcium Release Channel; SERCA2a; Sarcolemma; Sarcoplasm; Sarcoplasmic Reticulum; Signal Pathway; Signal Transduction; Somatotropin; Stimulus; Structure; Systole; TNF gene; Testing; Underserved Population; United States; Universities; Ventricular; Vertical Disease Transmission; Viral; Viral Load result; Virus; Woman; aged; antiretroviral therapy; bone; cardiovascular risk factor; cytokine; digital; genetic regulatory protein; health disparity; heart cell; heart function; high risk; improved; in utero; inflammatory marker; inhibitor; inorganic phosphate; minority health; minority health disparity; mortality; nano-string; neonatal period; neonate; neurodevelopment; pediatric human immunodeficiency virus infection; perinatal HIV; perinatal period; pharmacologic; pre-exposure prophylaxis; pregnant; prenatal exposure; protein expression; reduce symptoms; screening; side effect; social influence; success; tool; transmission process; trend; underserved community; underserved minority; whole genome; ATP phosphohydrolase; Accounting; Acquired Immunodeficiency Syndrome; Adolescence; Adolescent; Affect; Africa South of the Sahara; African; African American; Anatomy; Anti-Retroviral Agents; Antiviral Therapy; Apoptosis; Apoptotic; Biological Markers; Birth; Black race; Breast Feeding; C-reactive protein; Calcitonin Gene-Related Peptide; Calcium; Cardiac; Cardiac Myocytes; Cardiovascular Abnormalities; Cardiovascular Diseases; Cardiovascular system; Caring; Cell Hypoxia; Cell physiology; Cells; Cesarean section; Cessation of life; Child; Chronic; Chronic Disease; Clinical; Clinical Data; Country; Cytomegalovirus; Data; Development; Economic Factors; Effectiveness; Expectancy; Exposure to; FREQ gene; Female; Fetus; Functional disorder; Fura-2; Future; Gene Expression; Goals; Growth; HIV; HIV Infections; HIV diagnosis; HIV risk; HIV-exposed uninfected infant; HIV/AIDS; Health; Heart; Heart Abnormalities; Hispanic; Hormonal; Hospitalization; Human Milk; Hypertension; Image; Immune; Impairment; Incidence; Individual; Infant; Inflammation; Inflammatory; Inositol; Insulin-Like Growth Factor I; Intake; Investigation; Latina; Left; Life Expectancy; Life Style; Longevity; MAPK Signaling Pathway Pathway; Maternal-Fetal Transmission; Measures; Medical; Metabolism; Minerals; Minority Groups; Mitochondria; Mother-to-child HIV transmission; Mothers; Myocardial; Myocardial dysfunction; Myocarditis; Neonatal; Newborn Infant; Newly Diagnosed; Nuclear; Outcome; Oxidative Regulation; Oxidative Stress; PIK3CG gene; Pathway interactions; Peptides; Perinatal; Perinatal Infection; Persons; Pharmaceutical Preparations; Population; Potassium; Pregnancy; Pregnant Women; Prevention; Probability; Process; Public Health; Pump; Quality of life; Rattus; Recommendation; Recovery; Regimen; Regulation; Relaxation; Reporting; Research; Residual state; Rest; Risk; Rodent; Rodent Model; Role; Ryanodine Receptor Calcium Release Channel; SERCA2a; Sarcolemma; Sarcoplasm; Sarcoplasmic Reticulum; Signal Pathway; Signal Transduction; Somatotropin; Stimulus; Structure; Systole; TNF gene; Testing; Underserved Population; United States; Universities; Ventricular; Vertical Disease Transmission; Viral; Viral Load result; Virus; Woman; aged; antiretroviral therapy; bone; cardiovascular risk factor; cytokine; digital; genetic regulatory protein; health disparity; heart cell; heart function; high risk; improved; in utero; inflammatory marker; inhibitor; inorganic phosphate; minority health; minority health disparity; mortality; nano-string; neonatal period; neonate; neurodevelopment; pediatric human immunodeficiency virus infection; perinatal HIV; perinatal period; pharmacologic; pre-exposure prophylaxis; pregnant; prenatal exposure; protein expression; reduce symptoms; screening; side effect; social influence; success; tool; transmission process; trend; underserved community; underserved minority; whole genome

There are mounƟng evidence showing children exposed to HIV but uninfected (HEU) during pregnancy as the pregnant mother is on chronic cART present with higher cardiovascular risk at birth and beyond. In order to miƟgate these risks, there is an urgent need to understand the effects of the daily intake of the recommended HIV treatment, combined anƟretroviral therapy (cART), on the newborn during pregnancy. It is important to isolate the cardiac side effects of the cART in HEU from any residual maternal viral load effects. Therefore, we will study the effects the components of the cART given to non-infected pregnant rodent model on the HEU. Furthermore, an assessment of the breastieeding potenƟal compounding effect will be performed on breastied rodents. This study is of high relevance to the communiƟes with high HIV risk and cardiovascular diseases, such as in underserved populaƟon afflicted with health dispariƟes. Understanding the cause can help future studies to alleviate the symptoms.

有证据表明儿童暴露于艾滋病毒，但未感染（HEU） 怀孕作为怀孕的母亲在慢性购物车上，患有更高心血管风险 生日及以后。为了使这些风险增加这些风险，迫切需要了解 建议的艾滋病毒治疗的每日摄入量的影响，结合了抗病毒疗法 （购物车），在怀孕期间新生儿。隔离心脏副作用很重要 任何残留的母体病毒负荷效应的HEU手推车。因此，我们将研究 在HEU上影响未感染的未感染孕妇模型的CART的成分。 此外，对乳腺癌的potenɵal的复合效果的评估将是 在宽阔的啮齿动物上进行。这项研究与高度相关 艾滋病毒风险和心血管疾病，例如患有健康状况的人口不足。 dispariɵes。了解原因可以帮助未来的研究减轻症状。