FORWARD Supplement: Common Data Elements for Food Allergy

FORWARD 补充：食物过敏的通用数据元素

• 批准号: 10868981
• 负责人: Ruchi S Gupta
• 金额: $ 51.93万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-11 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10868981
• 关键词: Accounting; Adult; American; Black race; Child; Clinical; Clinical Trials; Collaborations; Collection; Common Data Element; Consensus; Data; Data Analyses; Development; Diagnostic; Food Hypersensitivity; Future; High Prevalence; Hispanic; Immune; Institution; Intervention Studies; Latino; Mediating; National Institute of Allergy and Infectious Disease; Observational Study; Outcome; Phenotype; Practice Management; Process; Quality of life; Recommendation; Recruitment Activity; Reproducibility; Research; Research Personnel; Site; Speed; United States National Institutes of Health; Work; clinical center; data dictionary; data interoperability; data standards; economic impact; ethnic disparity; improved; novel therapeutics; psychosocial; racial disparity; repository; stem

Food allergy is one of the most common immune-mediated conditions impacting 8% of children and 10% of adults in the US accounting for approximately 32 million Americans. Despite the massive clinical and economic impact of food allergy (FA), our ability to disentangle the many facets of the condition is limited by the lack of established common data elements (CDE). For example, even though clinicaltrials.gov lists over 500 FA studies (76 actively recruiting), the coverage of FA in the National Institutes of Health (NIH) CDE repository is minimal thus limiting the ability of investigators to compare results across interventional and observational studies. FORWARD is a multi-site study that systematically investigates racial and ethnic disparities between Black, White, and Hispanic/Latino children with FA in clinical and psychosocial outcomes, FA phenotypes and endotypes, and FA management practices. This supplement proposes to define CDEs using a rigorous consensus-based process that will increase the impact of the data analyses stemming from the FORWARD study. The FORWARD team of investigators in four sites will collaborate with experts from other academic institutions, as well as additional experts recommended by the National Institute of Allergy and Infectious Diseases (NIAID). Building on our prior FA Data Dictionary work, we propose to identify and develop a set of CDEs that can help provide consistency in the way FA clinical and research data are collected in FORWARD and beyond. Both FA diagnostics and therapies are evolving rapidly. Currently, our ability to compare various new therapies is limited by the lack of standardized data across studies. Development of FA CDEs will not only improve the consistency and interoperability of data in FORWARD, but also increase the speed and quality of future FA clinical trials to advance the understanding of this immune- mediated condition. Given the high prevalence of FA, and the impact on quality of life, accurate and reproducible collection of FA data can be of value to many other NIH’s institutes and centers, including the NIH Clinical Center.

食物过敏是影响8％儿童的最常见免疫介导的疾病之一 美国10％的成年人占约3200万美国人。尽管有 食品过敏（FA）的巨大临床和经济影响，我们解开许多人的能力 这种情况的方面受到缺乏既定的共同数据元素（CDE）的限制。为了 例如，即使临床。 美国国立卫生研究院（NIH）CDE存储库中FA的覆盖范围很小，因此限制 研究人员在介入和观察性研究中比较结果的能力。 Forward是一项多站点的研究，该研究系统地研究了种族和种族分布 在黑人，白人和西班牙裔/拉丁裔儿童之间，有临床和社会心理的FA 结果，FA表型和内型以及FA管理实践。此补充 建议使用严格共识的过程来定义CDS，以增加影响 来自远期研究的数据分析。调查人员的前进团队 在四个站点中，将与其他学术机构的专家合作，以及其他 美国国家过敏和传染病研究所（NIAID）推荐的专家。 在我们先前的FA数据字典工作的基础上，我们建议识别和开发一组CDE 这可以帮助提供FA临床和研究数据的一致性 向前及以后。 FA诊断和疗法都在迅速发展。目前，我们比较各种能力 新疗法受到整个研究中缺乏标准化数据的限制。 FA CDES的开发 不仅会提高数据中数据的一致性和互操作性，还可以提高 未来FA临床试验的速度和质量，以促进对这种免疫的理解 介导的状况。鉴于FA的高流行以及对生活质量的影响，准确 对于许多其他NIH的机构和中心，可再现的FA数据收集可能是有价值的， 包括NIH临床中心。

项目成果

Achieving Racial Representation in Food Allergy Research: A Modified Delphi Study.

在食物过敏研究中实现种族代表性：改进的德尔菲研究。

• DOI: 10.1016/j.jaip.2022.09.041
• 发表时间: 2023
• 期刊: The journal of allergy and clinical immunology. In practice
• 作者: Bilaver,LucyA;Galic,Isabel;Zaslavsky,Justin;Anderson,Brigitte;Catlin,PerryA;Gupta,RuchiS
• 通讯作者: Gupta,RuchiS

Associations of Food Allergy-Related Dietary Knowledge, Attitudes, and Behaviors Among Caregivers of Black and White Children With Food Allergy.

• DOI: 10.1016/j.jand.2021.11.017
• 发表时间: 2022-04
• 期刊: JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
• 影响因子: 4.8
• 作者: Vincent, Eileen;Bilaver, Lucy A.;Fierstein, Jamie L.;Thivalapill, Neil;Pappalardo, Andrea A.;Coleman, Amaziah;Robinson, Adam;Sharma, Hemant P.;Brewer, Audrey;Assa'ad, Amal H.;Jiang, Jialing;Hultquist, Haley W.;Kulkarni, Ashwin J.;Choi, Johnathan;Mahdavinia, Mahboobeh;Pongracic, Jacqueline;Tobin, Mary C.;Warren, Christopher;Gupta, Ruchi S.
• 通讯作者: Gupta, Ruchi S.

Managing Younger Siblings of Food Allergic Children.

管理食物过敏儿童的弟弟妹妹。

• DOI: 10.1016/j.iac.2019.07.001
• 发表时间: 2019
• 期刊: Immunology and allergy clinics of North America
• 影响因子: 2.6
• 作者: Agnihotri,NehaT;Lei,DawnK;Gupta,RuchiS
• 通讯作者: Gupta,RuchiS

Egg Allergy in US Children.

• DOI: 10.1016/j.jaip.2020.04.058
• 发表时间: 2020-10
• 期刊: The journal of allergy and clinical immunology. In practice
• 作者: Samady W;Warren C;Wang J;Das R;Gupta RS
• 通讯作者: Gupta RS

Food allergy-related bullying and associated peer dynamics among Black and White children in the FORWARD study.

• DOI: 10.1016/j.anai.2020.10.013
• 发表时间: 2021-03
• 期刊: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
• 作者: Brown D;Negris O;Gupta R;Herbert L;Lombard L;Bozen A;Assa'ad A;Chura A;Andy-Nweye AB;Fox S;Mahdavinia M;Tobin M;Robinson A;Sharma H;Coleman A;Jiang J;Bilaver L;Fierstein JL;Galic I;Newmark P;Pongracic JA;Pappalardo AA;Warren C
• 通讯作者: Warren C