Microscopy and Histopathology Core B

显微镜和组织病理学核心 B

基本信息

批准号：
10625993
负责人：
Jay Thiagarajah
金额：
$ 22.87万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10625993
关键词：
3-Dimensional Acceleration Area Biological Biology Biomedical Research Board Certification Boston Categories Clinical Research Collaborations Computers and Advanced Instrumentation Confocal Microscopy Consultations Core Facility Development Digestive System Disorders Documentation Electron Microscopy Emerging Technologies Epithelium Equipment Experimental Designs Faculty Financial Support Funding Future Gastrointestinal Surgical Procedures Gastrointestinal tract structure Grant Histology Histopathology Hospitals Hour Human Image Image Analysis Imaging technology Immune Infrastructure Institution Investigator-Initiated Research Israel Liver Location Medical center Metabolism Methods Microscope Microscopy Mission Mucosal Immunity Mucous Membrane Mus National Institute of Diabetes and Digestive and Kidney Diseases Optics Paper Pathogenesis Pathologist Pediatric Hospitals Productivity Qualifying Research Research Personnel Resolution Resources Rodent Science Services Site Structure Surface System Techniques Technology Training Translational Research United States National Institutes of Health Update Woman Work cost experience gut microbes human disease image processing immunocytochemistry innovation instrumentation interest medical schools member microbial nanoscale new technology programs research and development stem cell biology

项目摘要

Project Summary The mission of the Microscopy and Histopathology Core B is to provide HDDC members with basic and advanced microscope equipment, services and training, image processing resources, histology and histopathology support, and support for experimental design and scientific analysis that are essential for research in the digestive diseases. Core B, which is a long-standing component of the HDDC, is a successful collaboration among three independent imaging-based cores with their own financial structure that are each led by a director. The three sites are Beth Israel Deaconess Medical Center (Site A), Boston Children’s Hospital (Site B), and Brigham and Women’s Hospital (Site C). The three core sites are physically close to one another and unified by a Core Director who oversees the relationship of each satellite core with the HDDC and its membership. This infrastructure greatly benefits the HDDC membership by providing imaging equipment and expertise in locations highly populated with HDDC users while also providing options to amplify investigator-initiated research programs and enable new experimental approaches. This infrastructure also allows for the successful integration of other Harvard-based core facilities specializing in advanced instrumentation. Nine services were offered for Core B in the past 5-year grant cycle with 39 HDDC Principal Members and 13 Affiliate Members using Core B. Overall Core B recorded on average 4,200 billable service hours/year and 16,858 total billable hours over the last 4 year grant cycle (2015-2019) with 95 (primary use), 42 (secondary use), and 1 (tertiary use) original papers emerging from Core B utilization. HDDC support significantly extended grant dollars by reducing the cost of services by 25% or more for HDDC members. New innovations and equipment updates in the past grant cycle benefited, in particular, the electron microscopy and confocal microscopy services and their users. In the next grant cycle, the same nine services will be offered in Core B with 64 members indicating an interest in using Core B services. In the advanced microscopy category, one new service in high resolution 3-D electron microscopy will be available to HDDC members. Discounted services for HDDC Principal Members will continue to extend grant dollars and priority access for all HDDC members should facilitate greater productivity with cutting-edge instrumentation and expertise in the next grant cycle.

项目概要显微镜和组织病理学核心 B 的使命是为 HDDC 成员提供基本和先进的显微镜设备、服务和培训、图像处理资源、组织学和组织病理学支持，以及对实验设计和科学分析的支持，这对于研究方向为消化系统疾病。 Core B 是 HDDC 的一个长期组成部分，是三者之间的成功合作独立的基于成像的核心，具有自己的财务结构，每个核心均由一名董事领导。三个地点分别是贝斯以色列女执事医疗中心（地点 A）、波士顿儿童医院（地点 B）和布莱根妇女医院（C 地块）的三个核心站点物理上彼此靠近，并且由核心总监统一负责监督每个卫星核心与 HDDC 及其附属机构的关系该基础设施通过提供成像设备使 HDDC 会员受益匪浅。和 HDDC 用户密集地区的专业知识，同时还提供放大选项研究者发起的研究计划并启用新的实验方法。还可以成功整合哈佛大学其他专门从事先进技术的核心设施仪器仪表。在过去 5 年资助周期中，HDDC 的主要成员为 39 名，为核心 B 提供了 9 项服务和 13 名附属会员使用核心 B。总体核心 B 平均记录 4,200 项计费服务过去 4 年拨款周期（2015-2019）的总计费小时数为 16,858 小时/年，其中 95 小时（主要使用）、42 篇（二次使用）和 1 篇（三次使用）来自 Core B 使用的原始论文。通过将 HDDC 的服务成本大幅降低 25% 或更多来支持延长拨款过去的资助周期中的新创新和设备更新尤其使成员受益。电子显微镜和共焦显微镜服务及其用户。在下一个拨款周期中，核心 B 将提供相同的九项服务，其中 64 名成员表示对使用 Core B 服务的兴趣在高级显微镜类别中，这是一项高水平的新服务。分辨率 3-D 电子显微镜将向 HDDC 会员提供 HDDC 折扣服务。主要成员将继续为所有 HDDC 成员提供拨款和优先权在下一个拨款周期中利用尖端仪器和专业知识提高生产力。