Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users

雪茄口味对双重使用者烟草使用行为和成瘾的影响

基本信息

批准号：
10626066
负责人：
Erin Lucia Mead-Morse
金额：
$ 20.28万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-15 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626066
关键词：
Address Adoption Affect Affective Age Alcohols Award Behavior Behavioral Biological Markers Carcinogen exposure Characteristics Cigar Cigarette Clinical Trials Cognitive Collection Compensation Computer software Consumption Cotinine Crossover Design Data Data Collection Dependence Development Development Plans Disease Ecological momentary assessment Environment Equipment Faculty Flavoring Fruit Future Goals Grant Health Home Home environment Inhalation Intake Measurement Measures Menthol Mentors Methodology Methods Modeling Nicotine Participant Persons PhenX Toolkit Play Policy Maker Population Positioning Attribute Predisposition Price Process Public Health Regulation Research Research Personnel Research Priority Resources Risk Role Scientist Sensory Sex Differences Smoke Smoker Smoking Standardization Surveys Testing Tobacco Tobacco Dependence Tobacco use Training Vulnerable Populations Woman Writing addiction addiction liability age group behavioral economics career career development cigarette smoking cigarillos cost economic evaluation experience health disparity high risk indexing innovation men nicotine exposure non-cigarette tobacco product novel population health programs public policy on tobacco reduce tobacco use research and development sex standardize measure tobacco products tobacco regulation tobacco regulatory science uptake urinary young adult

项目摘要

PROJECT SUMMARY/ABSTRACT The rapid increase in popularity of dual use of flavored little cigars/cigarillos (LCCs) with cigarettes among U.S. young adults has significant implications for their health, addiction, and cessation. LCCs are used for two primary reasons: their relatively lower cost and flavor offerings. As cigarettes become more expensive or less reinforcing, young adults may substitute with attractively flavored LCCs rather than quit. We do not know the addictiveness of LCCs compared with cigarettes in dual users, the role that flavors play in addiction and dual use, and if flavors are more important for women than men. Moreover, the FDA has described research on cigars and flavors as a priority. Therefore, a critical need exists to characterize the addiction potential (AP) of flavored and unflavored LCCs compared with cigarettes and differences by sex in dual users. The specific aims are to: (1) characterize the AP of LCCs compared with cigarettes; (2) determine the extent to which the AP of LCCs varies by flavor and sex of user; and (3) determine the extent to which LCC use in the home environment differs by flavored vs. unflavored. The proposed study will employ a 3-week crossover design that combines survey-based measures (including behavioral economic assessments), biomarkers, and ecological momentary assessments (EMAs) of AP, dependence, and tobacco use behaviors among 145 non-treatment-seeking young adult (18-34 years old) dual users. AP will be characterized by behavioral economic indices of demand, such as the hypothetical consumption of LCCs at escalating prices, and other standardized measures of addiction. The impact of flavors on LCC and cigarette smoking at home will be captured by EMA. This information will address the following FDA priorities: impact of changes in LCC flavors on dependence and dual use behaviors, and innovative methods to assess tobacco use behaviors. The career development plan combines mentored hands-on training with coursework and professional development activities to meet the objectives critical to my transition to independent tobacco regulatory scientist. My career goal is to conduct research that develops our understanding of tobacco use in vulnerable populations, and informs tobacco regulation to reduce disease. I propose additional training in addictions research (including clinical trials), measurement of dependence and addiction potential, cigar regulatory research, and grantsmanship. With this training and my prior experience, I will be able to transition to an independent investigator of tobacco product flavorings and other characteristics that—with cognitive, affective, behavioral, and environmental influences—contribute to their uptake, use, and addiction. UConn Health, Brown, and Rutgers provide excellent resources for my career development, including formal coursework, seminars, expert faculty, research centers, office space, equipment, software, and data collection, analysis, and management resources. The focused training provided by this Award represents the final step in my career development and provides preliminary data and training for planned R-level grant writing.

项目摘要/摘要双重使用的小雪茄/雪茄（LCC）的迅速增长与香烟美国年轻人对他们的健康，成瘾和停止具有重要意义。 LCC用于两个主要原因：它们的相对较低的成本和风味。随着香烟变得更加昂贵或更少加强年轻人可能会用吸引人的LCC代替而不是退出。我们不知道 LCC与双重用户中的文明相比，味道在成瘾和双重用户中扮演的角色使用，如果口味比男性更重要。此外，FDA描述了有关的研究雪茄和口味作为优先事项。因此，存在着表征成瘾潜力（AP）的临界需求与香烟和双重用户的性别差异相比，味道和无味的LCC。具体目的是：（1）与香烟相比，LCC的AP表征；（2）确定 LCC的AP在范围内因用户的风味和性别而异；（3）确定LCC的程度在家庭环境中使用，通过调味料与未经味道区分。拟议的研究将雇用3周的员工结合基于调查的措施（包括行为经济评估）的跨界设计， AP，依赖性和烟草使用行为的生物标志物和生态瞬时评估（EMA）在145名非治疗的年轻人（18-34岁）双重用户中。 AP的特征是需求的行为经济指标，例如以不断上涨的价格对LCC的假设消费，和其他标准化的成瘾措施。口味对LCC和在家吸烟的影响将由EMA捕获。此信息将解决以下FDA优先级：LCC变化的影响依赖性和双重使用行为的口味以及评估烟草使用行为的创新方法。职业发展计划将指导的动手培训与课程和专业人士结合在一起开发活动以满足我向独立烟草监管过渡至关重要的目标科学家。我的职业目标是进行研究，从人群，并告知烟草调节以减少疾病。我建议其他培训研究（包括临床试验），依赖性和成瘾潜力的测量，雪茄调节性研究和授予技巧。通过这种培训和我的先前经验，我将能够过渡到烟草产品调味剂和其他特征的独立研究者（具有认知，情感，行为和环境影响 - 归因于它们的吸收，使用和成瘾。 UConn Health，布朗和罗格斯为我的职业发展提供了极好的资源，包括正式课程，半手，专家教师，研究中心，办公空间，设备，软件和数据收集，分析，和管理资源。该奖项提供的重点培训代表了我的最后一步职业发展并为计划的R级赠款写作提供初步数据和培训。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cigar-Smoking-Cessation Interest and Experience among Black Young Adults: A Semi-Structured In-Depth Interview Investigation.

DOI：
10.3390/ijerph18147309
发表时间：
2021-07-08
期刊：
International journal of environmental research and public health
影响因子：
0
作者：
Ajith A;Broun A;Duarte DA;Jewett B;Phan L;Mead-Morse EL;Guy MC;Choi K;Chen-Sankey J
通讯作者：
Chen-Sankey J

Manipulation of Menthol and Nicotine Content in Cigarettes: Effects on Smoking Behavior and Toxicant Exposure in Women Menthol Smokers.

香烟中薄荷醇和尼古丁含量的控制：对女性薄荷醇吸烟者吸烟行为和有毒物质暴露的影响。

DOI：
10.1093/ntr/ntac225
发表时间：
2023
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
0
作者：
Oncken,Cheryl;Litt,MarkD;Thurlow,Sheila;Mead-Morse,ErinL;Wang,Lanqing;Hatsukami,DorothyK
通讯作者：
Hatsukami,DorothyK