Electronic Cigarette Use During Pregnancy

怀孕期间使用电子烟

基本信息

批准号：
10172858
负责人：
Erin Lucia Mead-Morse
金额：
$ 14.54万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-16 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10172858
关键词：
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Abstinence Benefits and Risks Biological Markers Birth Birth Weight C-reactive protein Carbon Monoxide Carcinogen exposure Carcinogens Cessation of life Characteristics Cigarette Cigarette Smoker Cotinine Counseling Data Electronic cigarette Exhalation Formaldehyde Gestational Age Infant Inflammation Inflammatory Intake Intercellular Adhesion Molecules Link Low Birth Weight Infant Malignant Childhood Neoplasm Maternal and Child Health Measurement Measures Mediating Modality Nicotine Nitrosamines Outcome Participant Pattern Positioning Attribute Pregnancy Pregnancy Outcome Pregnant Women Premature Birth Process Measure Prospective cohort study Public Health Risk Serum Smoke Smoking Spontaneous abortion Surveys Time Tobacco Tobacco use Tobacco-Associated Carcinogen Toxic effect Toxicant exposure United States United States Food and Drug Administration Urine Woman alpha Toxin cigarette smoking cigarette user combustible cigarette electronic cigarette use electronic cigarette user fetal improved inflammatory marker maternal cigarette smoking neurotoxicity nicotine exposure non-smoker pregnant prenatal cigarette smoking quitline recruit reproductive outcome smoking cessation smoking during pregnancy tobacco products toxicant

项目摘要

Abstract: Electronic cigarettes are rapidly becoming popular as a substitute for cigarette smoking and as an adjunct for smoking cessation. Unfortunately, little is known about use of these new tobacco products in pregnant women. Although the best option would be for pregnant women to stop using tobacco products entirely, a central question for women who do not quit smoking is “Are electronic cigarettes a net benefit or harm in terms of toxicant exposure and birth outcomes?” Because electronic cigarettes do not burn tobacco, they may reduce carbon monoxide (CO) exposure (a toxin that may contribute to low birth weight and neurotoxicity) and carcinogen exposure, which has been linked to low birth weight and childhood cancer. However, a concern exists that electronic cigarettes may present risks in pregnancy that match or exceed those of cigarette smoking such as increased nicotine exposure (particularly in dual users), and an increase formaldehyde exposure, which has been linked to adverse reproductive outcomes in nonsmokers. We will recruit 125 pregnant smokers and 250 pregnant electronic cigarette users (125 women who use e- cigs exclusively during pregnancy, and 125 dual users). We will advise women to stop all tobacco use, and provide written materials and quitline referrals. Maternal toxicant exposure levels of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), formaldehyde, and cotinine (major metabolite of nicotine) will be obtained throughout pregnancy and infant levels of NNAL and cotinine will be obtained at the time of delivery. We will also obtain data on birth weight, gestational age, and other reproductive outcomes. Our primary objective is to compare toxicant exposure in pregnant women who use electronic cigarettes compared to women who smoke conventional cigarettes. We hypothesize that women who smoke conventional cigarettes exclusively will have higher NNAL and cotinine concentrations throughout pregnancy and at delivery than electronic cigarette users. We will also explore differences in urine formaldehyde levels. Another primary objective is to examine the impact of conventional cigarettes compared to electronic cigarettes on birth weight. We hypothesize that infants born to exclusive conventional cigarette smokers will have lower birth weights than those of electronic cigarette users. We will also examine mechanisms by which conventional and electronic cigarettes could impact birth weight and other reproductive outcomes using toxicant biomarkers as well as biomarkers of inflammation. Results from this project can be used to better inform clinicians who may be in a position to counsel pregnant women about the potential effects of electronic cigarette use during pregnancy.

抽象的：电子香烟迅速迅速越来越流行，以替代吸烟的替代品和辅助戒烟。不幸的是，关于在怀孕中使用这些新的烟草产品知之甚少妇女。尽管最好的选择是让孕妇完全停止使用烟草产品不戒烟的妇女的中心问题是“电子烟是净收益或危害由于电子烟不会燃烧烟草，它们可能会减少一氧化碳（CO）暴露（可能导致低出生体重和神经毒性的毒素）和致癌物暴露与低出生体重和儿童期癌症有关。但是，这是一个担心存在电子烟可能会出现与烟相匹配或超过香烟的风险吸烟，例如增加尼古丁的暴露（部分是双用户）和甲醛增加曝光与非吸烟者的不良复制结果有关。我们将招募125名怀孕吸烟者和250名怀孕的电子烟使用者（125名使用E-的女性 CIGS仅在怀孕期间，125位双重用户）。我们建议妇女停止所有烟草使用，并提供书面材料和戒烟线。母体有毒物特异性烟草的暴露水平致癌4-（甲基硝基氨基）-1-（3-吡啶基）-1-丁醇（Nnal），甲醛和cotinine（主要）在整个怀孕期间将获得尼古丁的代谢产物，而婴儿水平的Nnal和Cotinine将是在交货时获得。我们还将获得有关出生体重，胎龄和其他的数据生殖结果。我们的主要目的是比较使用电子烟的孕妇的毒物暴露与吸烟常规香烟的女性相比。我们假设吸烟的女人在整个怀孕期间，常规的香烟专门将具有较高的Nnal和可替宁浓度和交付时，比电子公民用户。我们还将探索尿液甲醛水平的差异。另一个主要目的是检查传统香烟的影响与电子卷烟相比出生体重。我们假设独家常规吸烟者出生的婴儿的婴儿会较低生日重量比电子文明用户的体重。我们还将研究传统的机制电子烟可能会影响出生体重和其他使用有毒生物标志物的生殖结果以及炎症的生物标志物。该项目的结果可用于更好地告知可能可以咨询的临床医生孕妇关于怀孕期间电子文明使用的潜在影响。