Medical Scientist Research Service Award

医学科学家研究服务奖

• 批准号: 10626028
• 负责人: Erik Sulman
• 金额: $ 145.13万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626028
• 关键词: Award; Medical; Research; Scientist; Services

Project Summary The overarching goal of the NYU Medical Scientist Training Program (MSTP) is to train students to move fluidly between the realms of rigorous experimental or computational biology and compassionate, evidence-based care of patients. We aim to train future physician-scientists who will make significant contributions to the advancement of biomedical science and health care and who will become the next generation of national leaders of academic medicine. The mechanism whereby we propose to accomplish these goals is to select a group of highly accomplished and motivated students who will complete both our medical and graduate curricula and finish our program with a dual MD and PhD degrees. Central to our Program is NYU School of Medicine (NYUSoM) and the Sackler Institute of Graduate Biomedical Sciences (SIGBS). The former is among the oldest in the nation with a long history of transformative biomedical research and a current ranking in the top 10 of research medical schools. The latter supports 16 training programs, confers PhD degrees, and emphasizes biostatistics & exploratory data analysis, grant writing, rigor and reproducibility, responsible conduct of research, and individual development plan. Importantly, our proposed MSTP is far more than the sum of these two parts. With more than a half-century of experience, our MSTP has evolved into a carefully constructed program that adds tremendous value to medical and graduate training. Value added components of the MSTP include academic/scientific (e.g. faculty and student organized seminars, annual retreats, and physician-scientist role model lunches), clinical enrichment during graduate school (e.g. clinicopathological conferences, medical grand rounds, and clinical preceptorships), community building (e.g. Big Sib program, mental wellness, student organized outings, and an annual retreat), and an extensive system of advising with emphasis on career development. We offer three pathways through the MSTP curriculum: a traditional pathway that incorporates graduate work in between the pre-clerkship and clerkship portions of medical school, one that allows for some clinical clerkships before graduate work, and an accelerated pathway that allows students to enter the three-year medical school curriculum that includes transition to post-graduate residency training at NYU. Paramount in our program is mentoring. Our 98 training faculty were selected from a pool of more than 230 principal investigators at NYUSoM to offer training in a wide spectrum cutting-edge biomedical research. All participating faculty above the rank of assistant professor have outstanding training records that demonstrate high standards of mentoring. They receive mandatory training in lab management and mentoring. Our trainees are selected from an exceedingly qualified pool of applicants. The program is highly competitive; this year we received 469 applications for a class of 10-12. Students are selected based on scholastic achievement, passion for and accomplishment in biomedical research, and the qualities of professionalism, judgement and empathy that are required of physicians. Great effort is made to enhance diversity by recruiting and retaining underrepresented minority students.

项目概要 纽约大学医学科学家培训计划 (MSTP) 的总体目标是训练学生流畅地移动 在严格的实验或计算生物学领域与富有同情心、基于证据的护理领域之间 的患者。我们的目标是培养未来的医师科学家，他们将为进步做出重大贡献 生物医学科学和医疗保健领域的杰出人物以及谁将成为下一代国家学术带头人 药品。我们建议实现这些目标的机制是选择一组高度 有成就和积极主动的学生，他们将完成我们的医学和研究生课程，并完成我们的课程 具有医学博士和博士学位的双学位项目。我们项目的核心是纽约大学医学院 (NYUSoM) 和 萨克勒生物医学科学研究所 (SIGBS)。前者是全国最古老的 具有悠久的变革性生物医学研究历史，目前位列研究型医学院前十名。 后者支持 16 个培训项目，授予博士学位，并强调生物统计学和探索性数据 分析、资助写作、严谨性和可重复性、负责任的研究行为以及个人发展 计划。重要的是，我们提出的 MSTP 远远超过这两部分的总和。历经半个多世纪 凭借丰富的经验，我们的 MSTP 已发展成为一个精心构建的计划，为医疗增添了巨大的价值 和研究生培训。 MSTP 的增值组成部分包括学术/科学（例如教师和学生） 组织研讨会、年度静修会和医师科学家榜样午餐会），期间进行临床丰富 研究生院（例如临床病理学会议、医学大查房和临床导师）， 社区建设（例如 Big Sib 计划、心理健康、学生组织的郊游和年度静修）， 以及注重职业发展的广泛建议系统。我们提供三种途径 MSTP 课程：一种传统途径，将研究生工作纳入实习前和实习期间 医学院的见习部分，允许在毕业工作之前进行一些临床见习，以及 加速途径，允许学生进入包括过渡在内的三年制医学院课程 纽约大学研究生住院医师培训。我们的计划中最重要的是指导。我们的98名培训师资 从 NYUSoM 的 230 多名主要研究人员中选出，提供广泛的培训 尖端生物医学研究。所有参赛教师助理教授以上职称均具有优秀 证明高标准指导的培训记录。他们在实验室接受强制性培训 管理和指导。我们的学员是从非常合格的申请者中挑选出来的。这 项目竞争激烈；今年，我们收到了 469 份 10-12 年级的申请。学生被选拔 基于学术成就、对生物医学研究的热情和成就，以及 医生所需要的专业精神、判断力和同理心。努力增强多样性 通过招募和留住代表性不足的少数族裔学生。

项目成果

Recurrent somatic mutations as predictors of immunotherapy response.

• DOI: 10.1038/s41467-022-31055-3
• 发表时间: 2022-07-08
• 期刊: Nature communications
• 影响因子: 16.6

A genome-scale screen for synthetic drivers of T cell proliferation.

• DOI: 10.1038/s41586-022-04494-7
• 发表时间: 2022-03
• 期刊: Nature
• 影响因子: 64.8

Predictive modeling of morbidity and mortality in COVID-19 hospitalized patients and its clinical implications.

• DOI: 10.1101/2020.12.02.20235879
• 发表时间: 2020-12
• 期刊: medRxiv
• 作者: Joshua M Wang;Wenke Liu;Xiaoshan Chen;M. McRae;J. McDevitt;D. Fenyö

Gene Expression Signature in Patients With Symptomatic Peripheral Artery Disease.

• DOI: 10.1161/atvbaha.120.315857
• 发表时间: 2021-04
• 期刊: Arteriosclerosis, thrombosis, and vascular biology
• 作者: Newman JD;Cornwell MG;Zhou H;Rockman C;Heguy A;Suarez Y;Cheng HS;Feinberg MW;Hochman JS;Ruggles KV;Berger JS
• 通讯作者: Berger JS

Preoperative Risk Factors for Adverse Events in Adults Undergoing Bowel Resection for Inflammatory Bowel Disease: 15-Year Assessment of the American College of Surgeons National Surgical Quality Improvement Program.

因炎症性肠病接受肠道切除术的成人不良事件的术前危险因素：美国外科医生学会国家手术质量改进计划的 15 年评估。

• DOI: 10.14309/ajg.0000000000002395
• 发表时间: 2023
• 期刊: The American journal of gastroenterology
• 作者: Fernandez,Cristina;Gajic,Zoran;Esen,Eren;Remzi,Feza;Hudesman,David;Adhikari,Samrachana;McAdams-DeMarco,Mara;Segev,DorryL;Chodosh,Joshua;Dodson,John;Shaukat,Aasma;Faye,AdamS
• 通讯作者: Faye,AdamS