Self-collimating Single Photon Emission Breast Tomography System with Three-Dimensional Sparse Position-Sensitive Detectors

具有三维稀疏位置敏感探测器的自准直单光子发射乳腺断层扫描系统

• 批准号: 10625452
• 负责人: RUTAO YAO
• 金额: $ 20.04万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625452
• 关键词: 3-Dimensional; Abbreviations; American; Anatomy; Architecture; Back; Breast; Clinical; Clinical Trials; Collimator; Computer Simulation; Dedications; Detection; Development; Diagnostic tests; Disease; Electroplating; Evaluation; Event; Gamma Rays; Image; Imaging Phantoms; Imaging technology; Individual; Lesion; Lifting; Location; Malignant Neoplasms; Mammography; Measures; Mechanics; Methods; Molecular; Morbidity - disease rate; Morphology; Pathologic; Pathway interactions; Patients; Performance; Photons; Play; Positioning Attribute; Property; Radiation Dose Unit; Radioactivity; Radioisotopes; Radiopharmaceuticals; Reporting; Resolution; Rod; Role; Scheme; Screening for cancer; Screening procedure; Side; Signal Transduction; Structure; System; Technology; Testing; Tracer; Woman; Work; breast cancer diagnosis; breast imaging; cancer diagnosis; contrast imaging; cost; design; detection platform; detector; effective therapy; image reconstruction; imaging detector; imaging system; improved; malignant breast neoplasm; mortality; novel; prevent; prototype; response; screening; stem; tomography; tumor

Project Summary Breast cancer is the most diagnosed cancer among American women and is projected to become the most common cancer globally in 2021. To minimize the morbidity and mortality of this disease, it is imperative to develop improved testing methods to enable more effective treatment. The proposed work is to develop a new Single Photon Emission Breast Tomography (SPEBT) scanner to carry out radionuclide tracer based molecular breast imaging which has demonstrated clear advantages in the early detection of cancer malignancy in clinical trials, because of its 1) capability to detect pathological functional changes which take place before morphological anatomical developments and 2) up-to pico-mole sensitivity, which stems from collecting signals directly at the molecular level. The SPEBT system will have a system detection efficiency of 3.5×10-2 and spatial resolution of 2-mm, which are 50 and 2 times better than that of state-of-the-art dedicated single photon emission molecular breast imaging cameras, respectively. The significant imaging performance improvement will ease existing concerns on radiation dose and the inability to detect tumors of less than 5-mm in size — issues that have prevented molecular breast imaging from playing a much more prominent role in clinical breast cancer diagnosis and screening. The enabling concept behind the high-performance of the SPEBT is a novel detector architecture, a three-dimensional sparse position-sensitive detector, that achieves collimation largely by and for itself, which is termed self-collimation. This architecture allows the SPEBT to achieve both high-resolution and high detection efficiency. This is a critical conceptual breakaway from the mechanical-collimator-based detector structure that single-photon emission imaging technology relies on for years — mechanical collimator mandates an inverse interdependency between the resolution and detection efficiency, therefore, sets a hard ceiling for overall imaging performance. The proposed approach opens up a broad path to better imaging performance for breast and other imaging applications. The proposed project is to design and evaluate a SPEBT system with optimized configurations and develop and test a proof-of-concept SPEBT prototype.

项目摘要 乳腺癌是美国女性中诊断得最多的癌症，预计 在2021年成为全球最常见的癌症。 这种疾病必须开发改进的测试方法以使其更有效 治疗。 拟议的工作是开发新的单个光​​子发射乳房断层扫描（SPEBT） 扫描仪进行基于放射线示踪剂的分子乳房成像，该分子成像已证明 由于其1个 检测形态学之前发生的病理功能变化的能力 解剖学发展和2）最新的pico摩尔灵敏度，从收集信号中植物 直接在分子水平。 SPEBT系统的系统检测效率为3.5×10-2，空间分辨率为 2毫米，比最先进的专用单照片好50和2倍 发射分子乳房成像相机。重要的成像性能 改善将减轻现有的关注辐射剂量的问题，并且无法检测到肿瘤 尺寸少于5毫米 - 阻止分子乳房成像玩的问题 在临床乳腺癌诊断和筛查中更为重要。 SPEBT高性能背后的有利概念是一个新颖的探测器 建筑是一个三维稀疏位置敏感探测器，可实现准直 在很大程度上是自身的，这被称为自我碰撞。该体系结构使SPEBT达到 达到高分辨率和高检测效率。这是一个关键的概念脱离 从单光子发射成像的基于机械授一体的检测器结构 技术依赖多年 - 机械准直仪授权逆相互依存 因此，在分辨率和检测效率之间为整体成像设定了坚硬的天花板 表现。提出的方法为更好的成像性能开辟了一条广阔的途径 乳房和其他成像应用。 拟议的项目是设计和评估具有优化配置的SPEBT系统 并开发和测试概念验证SPEBT原型。