BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10618156
• 负责人: Wendy B Bollag
• 金额: --
• 依托单位: CHARLIE NORWOOD VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618156
• 关键词: Adrenal Glands; Affect; Aging; Aldosterone; Angiotensin II; Applications Grants; Appointment; Archives; Award; Back; Biology; Book Chapters; Book Reviews; COVID-19; Calpain; Cell Maturation; Cell model; Cell physiology; Cells; Circulation; Communities; Cornea; Corneal Injury; Department of Defense; Dermatologic; Dermatology; Differentiation and Growth; Disease; Education; Endocrinology; Epidermis; Equipment; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Fellowship; Funding; Funding Agency; Grant; Hormones; Hypertension; Hypertriglyceridemia; Individual; Institution; International; Investigational Therapies; Journals; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Legal patent; Link; Lipids; Malignant neoplasm of prostate; Manuscripts; Mediating; Mediation; Medical Students; Medical center; Mentors; Mesenchymal Stem Cells; Mitochondria; Molecular; Names; Neurosciences; Obesity; Oklahoma; Oncogenes; Oncology; Ophthalmology; Pathologic; Patients; Peer Review; Pharmaceutical Preparations; Pharmacology; Phosphatidylglycerols; Physiological; Physiology; Population; Positioning Attribute; Principal Investigator; Process; Production; Productivity; Program Evaluation; Program Research Project Grants; Proliferating; Psoriasis; Publications; Published Comment; Publishing; Puerto Rican; Request for Applications; Research; Research Institute; Research Personnel; Role; Science; Scientist; Services; Signal Pathway; Signal Transduction; Signaling Molecule; Skin; Skin Carcinoma; Societies; Sodium Chloride; Soldier; System; Training; United States Food and Drug Administration; United States National Institutes of Health; Universities; Very low density lipoprotein; Veterans; Work; Zona Glomerulosa; anticancer research; aquaporin 3; blood pressure control; bone; career; cell growth; colon cancer treatment; combat; corneal epithelial wound healing; corneal epithelium; cost; editorial; high risk; interest; keratinocyte; lectures; medical schools; meetings; member; novel; pandemic disease; phospholipase D2; posters; professor; programs; protein kinase D; recruit; response; skin disorder; symposium; tumorigenesis; verticillin A; very low density lipoprotein triglyceride; vision science

Project Summary/Abstract This application requests the appointment of Dr. Wendy Bollag, a Research Physiologist at the Charlie Norwood VA Medical Center in Augusta, Georgia and a Professor of Physiology at the affiliate institution (Augusta University), to the position of Research Career Scientist. In the past five years, Dr. Bollag has been productive, publishing 29 peer-reviewed articles and more than 10 invited reviews, book chapters and commentaries, with 52 peer-reviewed articles and 26 invited reviews, book chapters and commentaries in the past 10 years. Dr. Bollag’s research in cell signaling seeks to understand the role of particular signaling molecules in various cell processes; this research has led to interesting findings in her systems of interest, keratinocytes of the skin epidermis and zona glomerulosa cells of the adrenal gland, as well as extension of this knowledge to collaborative projects in other systems, including corneal wound healing. In the case of the skin and the adrenal gland, Dr. Bollag is interested in determining the signaling pathways that underlie keratinocyte proliferation and differentiation to form the epidermis under normal and pathological conditions, as well as those that regulate aldosterone production in the adrenal zona glomerulosa. In the past 10 years the Bollag laboratory has made significant progress in projects examining these two processes, as evidenced by the many publications for which she is the senior author. Dr. Bollag has also received as Principal Investigator (PI) or Co-PI three National Institutes of Health (NIH) R01 awards, one R29 award and one R21 award, five VA Merit Awards (three to support her work in skin, one to fund studies in the adrenal gland and one to support a new study in the cornea), a VA Research Career Scientist Award, two VA Shared Equipment Evaluation Program (ShEEP) awards and multiple state and intramural grant awards. She also recently received, as Contact Co-PI, an NIH T35 training award (with Co-PI, Dr. Carlos Isales) to recruit medical students from three Puerto Rican medical schools to perform summer aging research. She has also served as a Co-Investigator on several awards, including an NIH P01 Program Project Award with her colleague and collaborator of approximately 35 years, Dr. Isales, and as the Lead Mentor on a Department of Defense mentoring partnership award to Albany State University. Last year she received the Augusta University Research Institute Distinguished Investigator Award; she was also invited to give a symposium presentation at the 2019 annual meeting of Experimental Biology. This year she was invited to present in the Blank Forum at the 2020 annual meeting of the Society for Investigative Dermatology (which was unfortunately cancelled due to the pandemic) and to give a named lecture at the Oklahoma Center of Neuroscience (postponed until 2021 because of COVID-19), indicating that she is recognized for her research. Finally, Dr. Bollag is an individual who is engaged with the community and involved in giving back in service at the institutional, local and national levels. Thus, she mentors junior colleagues, including Dr. Debra Irsik, a recent VA Career Development Award recipient, provides educational service to the affiliate institution (for which she has received numerous awards), serves as a reviewer for multiple journals and participates in review panels for several national and international funding agencies, including the VA. Currently, Dr. Bollag is an Editorial Consultant for the Journal of Investigative Dermatology, the highest impact journal in the field of dermatology research, a Senior Editor for the Journal of Endocrinology and the Journal of Molecular Endocrinology and a member of the editorial boards of the Journal of Lipid Research and Molecular Pharmacology. Thus, Dr. Bollag is an established investigator and a recognized mentor, who would adeptly fulfill the responsibilities of the Research Career Scientist designation.

项目摘要/摘要 该申请要求任命查理的研究生理学家温迪·博拉格博士 佐治亚州奥古斯塔的诺伍德VA医疗中心和分支机构机构的生理学教授 （奥古斯塔大学），在研究职业科学家的位置。在过去的五年中，博拉格博士一直 富有成效的，出版29篇由同行评审的文章，并有10个以上的邀请评论，书籍章节和 评论，有52篇经过同行评审的文章和26项受邀评论，书籍章节和评论 过去10年。 Bollag博士在细胞信号方面的研究旨在了解特定信号的作用 分子在各种细胞过程中；这项研究导致了她感兴趣的系统中有趣的发现， 皮肤表皮的角质形成细胞和肾上腺的Zona肾小球细胞，以及该延伸的延伸 了解其他系统中的协作项目，包括角膜伤口愈合。如果是皮肤 和肾上腺，Bollag博士有兴趣确定角质形成细胞的信号传导途径 在正常和病理条件下形成表皮的增殖和分化以及 这可以调节肾上腺Zona肾小球中的醛固酮产量。在过去的10年中，Bollag实验室 在研究这两个过程的项目方面取得了重大进展，许多出版物证明了这两个过程 她是高级作家。 Bollag博士还担任首席研究员（PI）或Co-Pi三 国立卫生研究院（NIH）R01奖，一项R29奖和一项R21奖，五项VA优异奖（三个 为了支持她在皮肤上的工作，一个用于资助肾上腺的研究，一个人支持一项新的研究 Cornea），VA研究职业科学家奖，两个VA共享设备评估计划（SHEEP） 奖项以及多个州和内部赠款奖。她最近还收到了联系Co-Pi，NIH T35培训奖（与Co-Pi，Carlos Isales博士）招募来自三个波多黎各医学的医学生 学校进行夏季老化研究。她还曾在多个奖项中担任共同研究员， 与她的同事和大约35年的合作者一起，包括NIH P01计划项目奖。 Isales，作为国防部指导伙伴关系奖的首席导师奖 大学。去年，她获得了奥古斯塔大学研究所杰出研究者奖； 她还被邀请在2019年实验生物学年度会议上进行研讨会演讲。这 她应邀请她在调查协会2020年年度会议上参加空白论坛。 皮肤病学（不幸的是由于大流行而取消），并在 俄克拉荷马州神经科学中心（由于1921年，推迟到2021年），表明她是 她的研究认可。最后，Bollag博士是一个与社区互动并参与的个人 回馈机构，地方和国家一级的服务。那，她指导了初级同事， 包括最近的VA职业发展奖获得者Debra Irsik博士，为该公司提供教育服务 会员机构（她获得了许多奖项），担任多个期刊的审阅者， 参加包括VA在内的几个国家和国际资助机构的审查小组。现在， Bollag博士是《调查皮肤病学杂志》的编辑顾问，这是影响最高的影响期刊 皮肤科研究领域，内分泌学杂志的高级编辑和《分子杂志》 内分泌学和脂质研究杂志编辑委员会成员 药理。那是Bollag博士是一位既定的调查员，也是公认的心态，他们会熟练地实现 研究职业科学家设计的责任。