BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10618156
• 负责人: Wendy B Bollag
• 金额: --
• 依托单位: CHARLIE NORWOOD VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618156
• 关键词: Adrenal Glands; Affect; Aging; Aldosterone; Angiotensin II; Applications Grants; Appointment; Archives; Award; Back; Biology; Book Chapters; Book Reviews; COVID-19; Calpain; Cell Maturation; Cell model; Cell physiology; Cells; Circulation; Communities; Cornea; Corneal Injury; Department of Defense; Dermatologic; Dermatology; Differentiation and Growth; Disease; Education; Endocrinology; Epidermis; Equipment; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Fellowship; Funding; Funding Agency; Grant; Hormones; Hypertension; Hypertriglyceridemia; Individual; Institution; International; Investigational Therapies; Journals; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Legal patent; Link; Lipids; Malignant neoplasm of prostate; Manuscripts; Mediating; Mediation; Medical Students; Medical center; Mentors; Mesenchymal Stem Cells; Mitochondria; Molecular; Names; Neurosciences; Obesity; Oklahoma; Oncogenes; Oncology; Ophthalmology; Pathologic; Patients; Peer Review; Pharmaceutical Preparations; Pharmacology; Phosphatidylglycerols; Physiological; Physiology; Population; Positioning Attribute; Principal Investigator; Process; Production; Productivity; Program Evaluation; Program Research Project Grants; Proliferating; Psoriasis; Publications; Published Comment; Publishing; Puerto Rican; Request for Applications; Research; Research Institute; Research Personnel; Role; Science; Scientist; Services; Signal Pathway; Signal Transduction; Signaling Molecule; Skin; Skin Carcinoma; Societies; Sodium Chloride; Soldier; System; Training; United States Food and Drug Administration; United States National Institutes of Health; Universities; Very low density lipoprotein; Veterans; Work; Zona Glomerulosa; anticancer research; aquaporin 3; blood pressure control; bone; career; cell growth; colon cancer treatment; combat; corneal epithelial wound healing; corneal epithelium; cost; editorial; high risk; interest; keratinocyte; lectures; medical schools; meetings; member; novel; pandemic disease; phospholipase D2; posters; professor; programs; protein kinase D; recruit; response; skin disorder; symposium; tumorigenesis; verticillin A; very low density lipoprotein triglyceride; vision science

Project Summary/Abstract This application requests the appointment of Dr. Wendy Bollag, a Research Physiologist at the Charlie Norwood VA Medical Center in Augusta, Georgia and a Professor of Physiology at the affiliate institution (Augusta University), to the position of Research Career Scientist. In the past five years, Dr. Bollag has been productive, publishing 29 peer-reviewed articles and more than 10 invited reviews, book chapters and commentaries, with 52 peer-reviewed articles and 26 invited reviews, book chapters and commentaries in the past 10 years. Dr. Bollag’s research in cell signaling seeks to understand the role of particular signaling molecules in various cell processes; this research has led to interesting findings in her systems of interest, keratinocytes of the skin epidermis and zona glomerulosa cells of the adrenal gland, as well as extension of this knowledge to collaborative projects in other systems, including corneal wound healing. In the case of the skin and the adrenal gland, Dr. Bollag is interested in determining the signaling pathways that underlie keratinocyte proliferation and differentiation to form the epidermis under normal and pathological conditions, as well as those that regulate aldosterone production in the adrenal zona glomerulosa. In the past 10 years the Bollag laboratory has made significant progress in projects examining these two processes, as evidenced by the many publications for which she is the senior author. Dr. Bollag has also received as Principal Investigator (PI) or Co-PI three National Institutes of Health (NIH) R01 awards, one R29 award and one R21 award, five VA Merit Awards (three to support her work in skin, one to fund studies in the adrenal gland and one to support a new study in the cornea), a VA Research Career Scientist Award, two VA Shared Equipment Evaluation Program (ShEEP) awards and multiple state and intramural grant awards. She also recently received, as Contact Co-PI, an NIH T35 training award (with Co-PI, Dr. Carlos Isales) to recruit medical students from three Puerto Rican medical schools to perform summer aging research. She has also served as a Co-Investigator on several awards, including an NIH P01 Program Project Award with her colleague and collaborator of approximately 35 years, Dr. Isales, and as the Lead Mentor on a Department of Defense mentoring partnership award to Albany State University. Last year she received the Augusta University Research Institute Distinguished Investigator Award; she was also invited to give a symposium presentation at the 2019 annual meeting of Experimental Biology. This year she was invited to present in the Blank Forum at the 2020 annual meeting of the Society for Investigative Dermatology (which was unfortunately cancelled due to the pandemic) and to give a named lecture at the Oklahoma Center of Neuroscience (postponed until 2021 because of COVID-19), indicating that she is recognized for her research. Finally, Dr. Bollag is an individual who is engaged with the community and involved in giving back in service at the institutional, local and national levels. Thus, she mentors junior colleagues, including Dr. Debra Irsik, a recent VA Career Development Award recipient, provides educational service to the affiliate institution (for which she has received numerous awards), serves as a reviewer for multiple journals and participates in review panels for several national and international funding agencies, including the VA. Currently, Dr. Bollag is an Editorial Consultant for the Journal of Investigative Dermatology, the highest impact journal in the field of dermatology research, a Senior Editor for the Journal of Endocrinology and the Journal of Molecular Endocrinology and a member of the editorial boards of the Journal of Lipid Research and Molecular Pharmacology. Thus, Dr. Bollag is an established investigator and a recognized mentor, who would adeptly fulfill the responsibilities of the Research Career Scientist designation.

项目概要/摘要 本申请要求任命查理研究所的研究生理学家 Wendy Bollag 博士 乔治亚州奥古斯塔的诺伍德退伍军人医疗中心及其附属机构的生理学教授 （奥古斯塔大学），担任研究职业科学家 在过去五年中，Bollag 博士一直担任研究职业科学家。 富有成效，发表了 29 篇同行评审文章和 10 多篇特邀评论、书籍章节和 评论，其中有 52 篇同行评审文章和 26 篇特邀评论、书籍章节和评论 Bollag 博士过去 10 年在细胞信号传导方面的研究旨在了解特定信号传导的作用。 各种细胞过程中的分子；这项研究在她感兴趣的系统中带来了有趣的发现， 皮肤表皮的角质形成细胞和肾上腺的肾小球带细胞，以及该细胞的延伸 其他系统中的协作项目的知识，包括皮肤伤口愈合。 Bollag 博士对确定角质形成细胞基础的信号传导途径感兴趣 在正常和病理条件下增殖和分化形成表皮，以及 Bollag 实验室在过去 10 年中发现了调节肾上腺球状带醛固酮生成的药物。 正如许多出版物所证明的那样，在检查这两个过程的项目中取得了重大进展 作为该研究的资深作者，Bollag 博士还获得了 3 项首席研究员 (PI) 或联合 PI 的称号。 美国国立卫生研究院 (NIH) R01 奖、一项 R29 奖和一项 R21 奖、五项 VA 优异奖（三项 支持她在皮肤方面的工作，一项资助肾上腺研究，一项支持一项新研究 角膜），一项 VA 研究职业科学家奖，两项 VA 共享设备评估计划 (ShEEP) 她最近还作为联系人 Co-PI 获得了 NIH 的奖项和多项州和校内资助奖。 T35 培训奖（与 Co-PI，Carlos Isales 博士一起）招募来自波多黎各三名医学生的医学生 她还曾担任多个奖项的联合研究员， 包括与她的同事和合作者大约 35 年的 NIH P01 计划项目奖，Dr. Isales，并担任奥尔巴尼州立大学国防部指导合作奖的首席导师 去年，她获得了奥古斯塔大学研究所杰出研究员奖； 她还受邀在2019年实验生物学年会上做研讨会报告。 同年，她受邀在调查协会 2020 年年会上的空白论坛上发表演讲 皮肤科（不幸的是由于大流行而取消）并在 俄克拉荷马州神经科学中心（因 COVID-19 推迟至 2021 年），表明她正在 最后，Bollag 博士是一位积极参与社区活动的人。 因此，她在机构、地方和国家层面回馈服务，指导初级同事， 其中包括最近获得 VA 职业发展奖的 Debra Irsik 博士，她为 附属机构（她为此获得了众多奖项），担任多种期刊的审稿人， 参加多个国家和国际资助机构（包括 VA）的审查小组。 Bollag 博士是《Journal of Investigative Dermatology》的编辑顾问，该杂志是全球影响力最高的期刊 皮肤病学研究领域，《内分泌学杂志》和《分子杂志》的高级编辑 内分泌学和《脂质研究与分子杂志》编委会成员 因此，Bollag 博士是一位成熟的研究者和公认的导师，他能够熟练地完成任务。 研究职业科学家称号的职责。