T32 University of Rochester Aging and Alzheimer's disease Training Program

T32 罗切斯特大学老龄化和阿尔茨海默病培训项目

• 批准号: 10617780
• 负责人: M. KERRY O'BANION
• 金额: $ 32.93万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617780
• 关键词: Aging; Alzheimer' s Disease; Training Programs; Universities

While fewer older adults are dying from heart disease and cancer, deaths from Alzheimer’s disease and related dementia’s (ADRD) have risen 145% in the last two decades. Progress to find a solution to this public health crisis has been slow. To help accelerate progress in the understanding, treatment, and prevention of ADRD, this application is for establishment of an NIA Institutional National Research Service Award (T32) titled, “University of Rochester Aging and Alzheimer’s Disease Training Program (UR-AADTP)”. Consistent with longstanding and established strengths at the University of Rochester in foundational and translational research on aging and ADRD, our goal is to accelerate the development and application of strategies to reduce the morbidity and mortality associated with ADRD. We seek support for six predoctoral fellows (3 slots in year 1) in basic and translational research programs who will undergo an innovative curriculum that emphasizes interdisciplinary science and informs their training through interactions with people affected by dementia and their health care providers. The UR-AADTP’s primary objective is to develop a cadre of early-stage scientists with the depth and breadth of knowledge, skills, appreciation, and experience necessary to establish careers as independent investigators in the area of dementia research; to work in an interdisciplinary environment designed to aggressively translate research to practice; and to reduce the toll of cognitive disorders in later life. The UR- AADTP T32 has these specific aims: Aim 1: We will recruit a diverse group of highly qualified predoctoral trainees who are committed to careers in aging research, retain them until their training is complete, and support their successful transitions to post- graduate academic positions. The trainees’ diversity will be reflected in their racial/ethnic backgrounds as well as the range of scientific disciplines and areas of research interest that they represent. Aim 2: Through courses, seminars and workshops, and mentored research experiences, we will provide UR- AADTP T32 trainees with a firm foundation in the theories and methods of basic and early translational aging research that are necessary for study of dementia pathogenesis and treatment development. Aim 3: By fostering interactions between trainees and faculty members trained in different theoretical and methodological approaches to aging and dementia research, we will stimulate interdisciplinary collaborations in aging research that accelerate the progress of dementia research, treatment and prevention. Aim 4: Through structured exposure to clinical settings, people affected by dementia, and the providers that care for them, trainees will appreciate the connections between research and practice necessary to accelerate the development of effective approaches to illness prevention and mitigation. Aim 5: We will rigorously evaluate the program and its participants (faculty and trainees).

虽然死于心脏病和癌症的老年人越来越少，但死于阿尔茨海默病和相关疾病的老年人却越来越少。 过去 20 年来，痴呆症 (ADRD) 增加了 145%。在寻找解决这一公共卫生问题的方法方面取得了进展。 为了帮助加速 ADRD 的理解、治疗和预防方面的进展，这一危机进展缓慢。 申请是为了设立 NIA 机构国家研究服务奖（T32），标题为“大学 罗彻斯特老龄化和阿尔茨海默病培训计划 (UR-AADTP)”与长期存在的一致。 罗切斯特大学在衰老和衰老的基础和转化研究方面建立了优势 ADRD，我们的目标是加速战略的开发和应用，以降低发病率和 我们寻求对基础和 ADRD 相关死亡率的六名博士前研究员（第一年的 3 个名额）的支持。 转化研究项目将接受强调跨学科的创新课程 科学并通过与痴呆症患者的互动及其医疗保健为他们的培训提供信息 UR-AADTP 的主要目标是培养一支具有深度和能力的早期科学家队伍。 建立独立职业所需的知识、技能、鉴赏力和经验的广度 痴呆症研究领域的研究人员；在跨学科环境中工作 积极地将研究转化为实践；并减少晚年认知障碍的发生。 AADTP T32 有以下具体目标： 目标1：我们将招募一批多元化的高素质博士前培训生，他们致力于以下领域的职业生涯： 老龄化研究，保留他们直到他们完成培训，并支持他们成功过渡到后 研究生学术职位的多样性也将反映在他们的种族/民族背景中。 作为它们所代表的科学学科和研究兴趣领域的范围。 目标 2：通过课程、研讨会和讲习班以及指导研究经验，我们将提供 UR- AADTP T32学员在基本​​和早期转化老化的理论和方法方面具有坚实的基础 研究痴呆发病机制和治疗开发所必需的研究。 目标 3：通过促进接受过不同理论和培训的学员和教师之间的互动 老龄化和痴呆症研究的方法论方法，我们将促进跨学科合作 衰老研究加速痴呆症研究、治疗和预防的进展。 目标 4：通过结构化接触临床环境，了解痴呆症患者以及提供治疗的医疗服务提供者 关心他们，学员将欣赏研究与实践之间的联系，这是加速发展所必需的 制定预防和减轻疾病的有效方法。 目标 5：我们将严格评估该计划及其参与者（教师和学员）。