SBIR TOPIC 401 PHASE II:

SBIR 主题 401 第二阶段：

• 批准号: 10923637
• 负责人: PEYMON GHAZI, PH.D.
• 金额: $ 199.81万
• 依托单位: MALCOVA INC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-09-17
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10923637
• 关键词: 3-Dimensional; Anatomy; Brain; Brain imaging; Breast; Clinical Trials; Development; Diagnostic; Ensure; Health; Investigation; Life; Methods; Organ; Patient Recruitments; Patients; Performance; Phase; Prostate; Radiation therapy; Risk Reduction; Safety; Shapes; Small Business Innovation Research Grant; Speed; Technology; X-Ray Computed Tomography; breast imaging; cancer imaging; commercialization; design; fabrication; improved; large datasets; lung imaging; malignant breast neoplasm; novel strategies; validation studies

As long as breast cancer remains a pervasive health concern, the need for ever-improving breast cancer imaging and radiation therapy technologies will exist. Design changes – to incorporate new hardware technologies or methods - may trigger the need for clinical trials to ensure safety and assess performance. Conducting a clinical trial is not only expensive, but often takes years for patient recruitment and study. Utilizing physical phantoms, rather than patients, would be faster, far less expensive, reduces risk to patients and potentially increases the speed with which life-saving technological advances are made available to the public. Currently, commercially available compressed and uncompressed breast phantoms do not produce realistic breast images; rather they provide basic breast shapes with no anatomical information. Utilizing access to a large data set (over 200) of three-dimensional real patient breast CT images at UC Davis, and a novel approach to phantom development, we propose to fill this need. In this Phase II SBIR project, we will develop, and commercialize, patient-derived anthropomorphic phantoms for use in diagnostic and radiation therapy applications. We will also investigate the utility of our core technology in developing anthropomorphic phantoms for prostate, brain, and lung imaging applications.

只要乳腺癌仍然是普遍的健康问题，就需要对乳腺癌成像和放射治疗技术的不断提高。设计更改（以结合新的硬件技术或方法 - 可能会触发临床试验的需求，以确保安全性和评估性能。进行临床试验不仅昂贵，而且通常需要数年的时间才能进行患者招募和学习。利用物理幻影而不是患者的速度将更快，便宜得多，可以降低患者的风险，并有可能提高为公众提供挽救生命的技术进步的速度。当前，市售的压缩和未压缩的乳房幻像不会产生逼真的乳房图像。相反，它们提供基本的乳房形状，没有解剖信息。利用加州大学戴维斯（UC Davis）的三维实际患者乳房CT图像的大型数据集（超过200多个）的访问，以及一种新颖的幻影开发方法，我们建议满足这一需求。在此II阶段SBIR项目中，我们将开发和商业化患者衍生的拟人化幻象，用于诊断和放射治疗应用。我们还将研究我们的核心技术在为前列腺，大脑和肺部成像应用开发拟人化幻象方面的实用性。