Administrative Core A

行政核心A

• 批准号: 9208531
• 负责人: Anthony B. Firulli
• 金额: $ 18.26万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-15 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9208531
• 关键词: Address; Animals; Applications Grants; Area; Biohazardous Substance; Budgets; Cardiomyopathies; Clinical; Congenital Abnormality; Congenital Heart Defects; Defect; Development; Disease; Ethics; Etiology; Goals; Growth; Health; Human; Individual; Mission; Molecular; Morphogenesis; National Heart, Lung, and Blood Institute; Outcome; Output; Participant; Phenotype; Prevention; Program Research Project Grants; Radiation; Reporting; Research; Research Project Grants; Research Proposals; Resource Sharing; Schedule; Services; Travel; United States National Institutes of Health; Ventricular; congenital heart disorder; meetings; pediatric patients; programs; public health relevance; symposium

ABSTRACT Congenital heart disease (CHD) is the most common birth defect. Among various CHDs, defects that result in altered ventricular morphogenesis have the poorest clinical prognoses. Currently, there is a poor understanding of the molecular mechanisms and cellular etiology causative of the many forms of ventricular CHDs. The central theme of this Program Project Grant is to elucidate mechanisms that regulate growth and morphogenesis of the ventricle during development. Core A provides central administration of the Program Project Grant activities, which serves to enhance scientific interactions, resource sharing, collaborative interactions, and compliance requirements for all participants of this Program Project grant. The ultimate goal of Core A is to enhance Project efficiency and scientific output. RELEVANCE CHDs resulting in ventricle phenotypes have the poorest clinical outcomes. Thus, gaining an understanding of the etiology and molecular mechanisms that cause CHDs resulting in altered ventricular morphogenesis has the potential to benefit thousands of pediatric patients annually.

抽象的 先天性心脏病（CHD）是最常见的出生缺陷。在各种 CHD 中，导致的缺陷 心室形态发生改变的临床预后最差。目前，有一个贫困 了解导致多种形式心室的分子机制和细胞病因学 冠心病。该计划项目拨款的中心主题是阐明调节增长和 发育过程中心室的形态发生。 核心 A 提供计划项目拨款活动的集中管理，旨在加强 科学互动、资源共享、协作互动以及所有人的合规要求 该计划项目资助的参与者。核心A的最终目标是提高项目效率和 科学产出。 关联 导致心室表型的冠心病临床结果最差。从而，了解 导致冠心病导致心室形态发生改变的病因学和分子机制 每年有可能使数千名儿科患者受益。