Core: Biorepository and Clinical Trial Office Shared Resource

核心：生物样本库和临床试验办公室共享资源

• 批准号: 10911643
• 负责人: STEVEN L. CARROLL
• 金额: $ 2.22万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10911643
• 关键词: Academic Medical Centers; Address; African ancestry; Biological; Black Populations; Blood; Breast Cancer Patient; Cancer Center; Caring; Clinical; Clinical Research; Clinical Trials; Communities; Data; Development; Enrollment; Ethnic Origin; Faculty; Funding; Future; Goals; Health Services Research; Infrastructure; Leadership; Malignant Neoplasms; Malignant neoplasm of prostate; Medical center; Minority; Morbidity - disease rate; Outcome; Patients; Population Heterogeneity; Provider; Quality of life; Research; Research Personnel; Research Project Grants; Resource Sharing; South Carolina; Specimen; Survivors; Tissues; Universities; anticancer research; biobank; cancer care; cancer health disparity; care delivery; clinical center; clinical trial implementation; community setting; ethnic diversity; implementation facilitation; improved; mortality; outcome disparities; patient oriented; patient population; racial diversity; racial minority; research study; rural area

BIOREPOSITORY AND CLINICAL TRIALS OFFICE SHARED RESOURCE SUMMARY The establishment and implementation of the South Carolina Cancer Disparities Research Center (SC CADRE) Biorepository/Clinical Trials Office (CTO) Shared Resource is expected to significantly expand the research capacity of the SC CADRE investigators at South Carolina State University (SCSU), thus enhancing their ability to compete for independent, R01-level funding. This new, dual-component Shared Resource will also augment SCSU's ability to attract additional junior faculty researchers who will have access to biospecimens from racially and ethnically diverse patient populations as well as to clinical trials infrastructure at the Regional Medical Center of Orangeburg Mabry Cancer Center (RMC-MCC). The overarching goal of the Biorepository/CTO Shared Resource is to support the development of cancer research at SCSU through both a Biorepository component and a CTO component. The Biorepository component will give SC CADRE investigators access to the RMC-MCC's patient blood and tissue specimens that were previously unavailable for research due to the lack of a biorepository infrastructure. Likewise, the CTO component will facilitate the implementation of clinical trials, providing an infrastructure for SCSU investigators to conduct research in their Orangeburg, SC community as well as providing the Orangeburg community immediate access to other NCI- approved clinical trials which have not been available to date. This Shared Resource will support the implementation of two initial SC CADRE clinical trials in Years 1-3 which will provide the biological and outcomes data needed to evaluate the hypothesized relationships that are being assessed in each of the three initial SC CADRE Full and Pilot Research Projects. Additionally, this Biorepository/CTO Shared Resource will support future SC CADRE Full and Pilot Research Projects as well as other NCI-approved clinical research studies at the RMC-MCC, with the goal of enhancing participation of diverse populations in cancer clinical research.

生物验证和临床试验办公室共享资源 概括 南卡罗来纳州癌症差异研究中心的建立和实施（SC Cadre）生物座席/临床试验办公室（CTO）共享资源有望显着扩展 南卡罗来纳州立大学（SCSU）的SC干部研究人员的研究能力，从而增强 他们争夺独立的R01级资金的能力。这个新的双重组件共享资源将 还增强了SCSU吸引其他初级教师研究人员的能力，他们将可以使用 来自种族和种族多样化的患者人群以及临床试验基础设施的生物测量 奥兰治堡马布里癌症中心（RMC-MCC）地区医疗中心。总体目标 Biorepository/CTO共享资源是通过两者都支持SCSU的癌症研究的发展 生物座位组件和CTO组件。生物座位组件将为SC干部提供 研究人员可以使用以前无法使用的RMC-MCC患者血液和组织标本 由于缺乏生物座席基础设施而进行研究。同样，CTO组件将有助于 实施临床试验，为SCSU调查人员提供基础设施，以进行其研究 奥兰治堡，南卡罗来纳州社区，并为奥兰治堡社区立即访问其他NCI- 迄今尚未获得的批准临床试验。此共享资源将支持 在1 - 3年内实施两项初始SC干部临床试验，这将提供生物学和 结果数据需要评估三个中每个人的假设关系 最初的SC Cadre Full and Pilot研究项目。此外，此BioreSository/CTO共享资源将 支持未来的SC Cadre Full和Pilot Research项目以及其他NCI批准的临床研究 在RMC-MCC的研究，目的是增强各种人群参与癌症临床 研究。