Assessing the acceptability, feasibility, and a potential distribution model of HIV oral self-testing (HST) among men who have sex with men (MSM) in Lagos, Nigeria

评估尼日利亚拉各斯男男性行为者 (MSM) 中 HIV 口腔自检 (HST) 的可接受性、可行性和潜在分布模型

• 批准号: 9261476
• 负责人: ADEKEMI SEKONI
• 金额: $ 10.29万
• 依托单位: POPULATION COUNCIL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2018-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9261476
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adult; Affect; Africa; Behavioral; Caring; Cities; Collaborations; Communities; Counseling; Department of Defense; Discrimination; Early treatment; Ensure; Environment; Face; Focus Groups; Funding; Goals; Guidelines; HIV; HIV Seropositivity; HIV diagnosis; High Prevalence; Homophobia; Human Rights Abuses; Human immunodeficiency virus test; Influentials; Institution; Instruction; Intervention; Interview; Link; Measures; Modeling; Nigeria; Nigerian; Outcome; Participant; Persons; Policies; Policy Maker; Population; Prevalence; Preventive Intervention; Research Activity; SERPINI2 gene; Safety; Sampling; Services; Sexual Partners; Social Network; Stigmatization; Subgroup; Surveys; Test Result; Testing; Time; United States National Institutes of Health; Universities; Ursidae Family; Viral; care seeking; cohort; evidence base; experience; follow-up; high risk population; implementation science; improved; innovation; interest; learning materials; male; member; men who have sex with men; men' s group; oral HIV; outreach; peer; post intervention; programs; public health relevance; response; service utilization; social; social stigma; success; uptake; willingness

 DESCRIPTION (provided by applicant): The Population Council and University of Lagos propose to conduct a feasibility and acceptability study of HIV self-testing (HST) among men who have sex with men (MSM) in Lagos, Nigeria. MSM in Nigeria bear a disproportionately high burden of HIV (17%) and face high levels of stigma, discrimination, and criminalization. In such a hostile and homophobic environment where human rights abuses are rife, MSM have poor access to HIV prevention, care and treatment services, including HIV testing and counselling (HTC). In addition, 55% of Nigerian MSM and 62% of MSM in Lagos have never tested for HIV, suggesting that many HIV-positive MSM are not linked to care and treatment. The goal of this study is to address a critical barrier to MSM accessing HIV testing and treatment by testing the acceptability, feasibility, and a potential peer-driven distribution model of HST among MSM in Nigeria. The aims of this proposal are: 1) To investigate the acceptability, feasibility, and operational aspects of an HST distribution through the use of key opinion leaders (KOLs; or MSM peer educators) in Lagos, Nigeria; and 2) To examine real-world distribution feasibility, product uptake and utilization, and linkages to post-test counselling and treatment by implementing a distribution model wherein KOLs are deployed to distribute HST kits to MSM in their social networks. Outcomes of interest are uptake of HST, use of HST by sex partners, and linkage to post-test counselling and treatment. To meet Aim 1, in-depth interviews (IDI) with MSM and focus group discussions (FGD) with KOLs will be conducted to understand how MSM perceive HST, assess willingness to use and potential barriers to uptake of HST, and identify operational and contextual issues that might affect the demonstration, distribution, and utilization of HST kits among MSM. Observations of a small sample of MSM conducting HIV self-testing on will also be conducted to assess accurate use of the product, and revise product instructions accordingly. To meet Aim 2, a quantitative survey with a cohort of HIV negative or unknown status MSM (N=300) who are reached by KOLs will be conducted. Follow-up interviews will be conducted after three months to allow for sufficient time for those who test positive to seek care and treatment. IDIs with a subsample of the cohort will be conducted post-intervention to assess acceptability, ease of and barriers to use, unintended consequences, reasons for use or non-use, and facilitators of and barriers to linkages to care and treatment. FGDs with KOLs will also be conducted at endline to assess operational aspects and challenges to HST kit distribution. The proposed study builds on Population Council's existing PEPFAR-funded (Department of Defense) service delivery program that has successfully been using KOLs to deliver important HIV services to MSM in Lagos. The study will provide critical information on how self-testing can be offered to a high-risk group with low rates of HIV testing. It will also bridge evidence gaps and facilitate policy changes to include HST into national HIV testing guidelines.

 描述（由申请人提供）：人口委员会和拉各斯大学提议对尼日利亚拉各斯的男男性行为者 (MSM) 进行艾滋病毒自我检测 (HST) 的可行性和可接受性研究。艾滋病毒负担过高（17%），并面临严重的耻辱、歧视和刑事定罪。在这种充满敌意和仇视同性恋的环境中，侵犯人权的行为无处不在，男男性接触者很难获得艾滋病毒预防、护理和治疗服务。此外，55% 的尼日利亚 MSM 和 62% 的拉各斯 MSM 从未进行过 HIV 检测，这表明许多 HIV 阳性 MSM 与护理和治疗无关。旨在通过测试尼日利亚 MSM 中 HST 的可接受性、可行性和潜在的同伴驱动分配模型来解决 MSM 获得 HIV 检测和治疗的关键障碍。该提案的目的是： 1) 调查可接受性、可行性。 ， 和通过使用尼日利亚拉各斯的关键意见领袖（KOL；或 MSM 同伴教育者）来了解 HST 分发的运营方面；以及 2) 检查现实世界中分发的可行性、产品的吸收和利用以及与测试后咨询和培训的联系；通过部署 KOL 向其社交网络中的 MSM 分发 HST 工具包来实现治疗，目标结果是 HST 的吸收、性伴侣对 HST 的使用以及与测试后咨询和治疗的联系。目标 1，将与 MSM 进行深度访谈 (IDI)，并与 KOL 进行焦点小组讨论 (FGD)，以了解 MSM 如何看待 HST，评估使用 HST 的意愿和采用 HST 的潜在障碍，并确定可操作和背景问题可能会影响 MSM 中 HST 试剂盒的展示、分发和使用。还将对进行 HIV 自检的 MSM 进行小样本观察，以评估产品的准确使用情况，并相应地修改产品说明书。目标2，将在三个月后对KOL接触到的HIV阴性或状态不明的MSM群体（N=300）进行定量调查，以便为检测呈阳性的人留出足够的时间。将在干预后对队列的子样本进行 IDI，以评估使用的可接受性、难易程度、意外后果、使用或不使用的原因以及联系的促进因素和障碍。还将与 KOL 一起在终点进行 FGD，以评估 HST 套件分发的操作方面和挑战。拟议的研究以人口委员会现有的 PEPFAR 资助的（国防部）服务提供计划为基础，该计划已成功地使用 KOL 来进行护理和治疗。该研究将提供有关如何向艾滋病毒检测率低的高危群体提供自我检测的重要信息，并促进政策变革，以包括这些服务。 HST 纳入国家艾滋病毒检测指南。

项目成果

'I will welcome this one 101%, I will so embrace it': a qualitative exploration of the feasibility and acceptability of HIV self-testing among men who have sex with men (MSM) in Lagos, Nigeria.

I%20will%20welcome%20this%20one%20101%,%20I%20will%20so%20拥抱%20it:%20a%20定性%20探索%20of%20the%20可行性%20和%20可接受性%20of%20HIV%20自我测试

• 发表时间: 2020
• 影响因子: 2.4
• 作者: Dirisu, Osasuyi;Sekoni, Adekemi;Vu, Lung;Adebajo, Sylvia;Njab, Jean;Shoyemi, Elizabeth;Ogunsola, Sade;Tun, Waimar
• 通讯作者: Tun, Waimar

Operationalizing the distribution of oral HIV self-testing kits to men who have sex with men (MSM) in a highly homophobic environment: the Nigerian experience.

在高度仇视同性恋的环境中向男男性行为者（MSM）分发口服艾滋病毒自检套件：尼日利亚的经验。

• 发表时间: 2022-01-06
• 影响因子: 4.5
• 作者: Sekoni, Adekemi;Tun, Waimar;Dirisu, Osasuyi;Ladi;Shoyemi, Elizabeth;Adebajo, Sylvia;Ogunsola, Folasade;Vu, Lung
• 通讯作者: Vu, Lung

Uptake of HIV self-testing and linkage to treatment among men who have sex with men (MSM) in Nigeria: A pilot programme using key opinion leaders to reach MSM.

尼日利亚男男性行为者 (MSM) 接受艾滋病毒自我检测并与治疗联系起来：一项利用关键意见领袖接触 MSM 的试点计划。

• 发表时间: 2018-07
• 影响因子: 6
• 作者: Tun, Waimar;Vu, Lung;Dirisu, Osasuyi;Sekoni, Adekemi;Shoyemi, Elizabeth;Njab, Jean;Ogunsola, Sade;Adebajo, Sylvia
• 通讯作者: Adebajo, Sylvia