Fatty Acids and Major Cardiovascular Outcomes

脂肪酸和主要心血管结局

• 批准号: 7643868
• 负责人: DARIUSH MOZAFFARIAN
• 金额: $ 50.05万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7643868
• 关键词: Acids; Address; Affect; Atrial Fibrillation; Cardiac; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Clinical; Cohort Studies; Collaborations; Congestive Heart Failure; Coronary heart disease; Diet; Diet Habits; Diet Records; Dietary Factors; Dietary intake; Disease; Elderly; Electrophysiology (science); Etiology; Evaluation; Event; Fatty Acids; Fatty acid glycerol esters; Fishes; Goals; Health; Heart failure; Incidence; Inflammation; Institution; Investigation; Ischemic Stroke; Label; Lipids; Measurement; Measures; Morbidity - disease rate; Myocardial Infarction; Nutritional; Obesity; Omega-3 Fatty Acids; Outcome; Phospholipids; Plant Sources; Plants; Plasma; Prevalence; Prevention; Public Health; Questionnaires; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Sampling; Seafood; Soybeans; Statutes and Laws; Stroke; Structure; Sudden Death; Trans Fats; Trans Fatty Acids; Work; adjudicate; cardiovascular disorder risk; case control; cohort; cost; design; disease phenotype; disorder risk; heart disease risk; hemodynamics; high risk; insulin sensitivity; meetings; mortality; novel; population based; prevent; programs; prospective

DESCRIPTION (provided by applicant): With advancing age, the incidence and prevalence of congestive heart failure (CHF), atrial fibrillation (AF), and stroke rise dramatically, producing major burdens of morbidity and mortality. Dietary intakes of n-3 fatty acids and trans-fatty acids influence many cardiovascular disease (CVD) risk factors, including risk factors for CHF, AF, and stroke. However, relations between n-3 and trans-fatty acids and these major CVD endpoints are not well-established. In prior studies, we have demonstrated that reported dietary habits are independently associated with incidence of CVD events in older adults. We have particularly focused on effects of different fish meals and hypothesized that the observed relations with disease risk may be due to n-3 or trans-fatty acids. Estimation of dietary intake of specific fatty acids using diet questionnaires can be challenging. In prior work using case-control designs, we have demonstrated that direct measurement of phospholipid n-3 and trans-fatty acids provides an objective measure of exposure and allows direct investigation of relations between these fatty acids and risk of coronary heart disease. We propose to measure plasma phospholipid fatty acids in stored samples among 4,766 older adults in the Cardiovascular Health Study, a population-based, multicenter cohort study of CVD risk, to investigate prospectively the association between n-3 and trans-fatty acids and incidence of CHF, AF, stroke, and total mortality. Fatty acids will be assessed using plasma stored in 1992, with events prospectively ascertained and adjudicated. For each of these outcomes, we hypothesize that n-3 fatty acids (both seafood and plant-derived) will be associated with lower risk, while trans-fatty acids will be associated with higher risk. As a secondary aim, we will elucidate potential mechanisms for CVD effects by evaluating the relations of these fatty acids with measures of hemodynamics, cardiac structure and function, electrophysiology, insulin sensitivity, inflammation, endothelial function, and obesity. These aims directly address the NIH's goal to investigate the role of nutritional factors for causation or prevention of CHF. The results of this proposed research will be highly relevant to public health, identifying dietary factors which may influence risk of major disease endpoints in older adults, including heart failure, atrial fibrillation, stroke, and death.

描述（由申请人提供）：随着年龄的增长，充血性心力衰竭的发病率和患病率（CHF），心房颤动（AF）和中风急剧上升，产生了严重的发病率和死亡率负担。 N-3脂肪酸和反式脂肪酸的饮食摄入量会影响许多心血管疾病（CVD）危险因素，包括CHF，AF和中风的危险因素。但是，N-3与反式脂肪酸与这些主要CVD终点之间的关系并不确定。在先前的研究中，我们已经证明了据报道的饮食习惯与老年人中CVD事件的发生率独立相关。我们特别关注不同鱼粉的影响，并假设观察到的与疾病风险的关系可能是由于N-3或反式脂肪酸引起的。使用饮食问卷估算特定脂肪酸的饮食摄入可能是具有挑战性的。在使用病例对照设计的先前工作中，我们证明了磷脂N-3和反式脂肪酸的直接测量提供了客观的暴露量，并允许直接研究这些脂肪酸与冠状动脉疾病风险之间的关系。我们建议在心血管健康研究中测量4,766名老年人中存储的样品中的血浆磷脂脂肪酸，这是一项基于人群的CVD风险的基于人群的多中心队列研究，以研究N-3与反式脂肪酸之间的关联，以及CHF，AF，AF，AF，AF，STROKE和总死亡率之间的关联。脂肪酸将使用1992年存储的血浆评估，并进行了前瞻性确定和裁决的事件。对于这些结果中的每一个，我们假设N-3脂肪酸（海鲜和植物来源）将与较低的风险有关，而反式脂肪酸将与较高的风险有关。作为次要目的，我们将通过评估这些脂肪酸与血液动力学，心脏结构和功能，电生理学，胰岛素敏感性，炎症，内皮功能和肥胖的关系来阐明对CVD效应的潜在机制。这些目的直接解决了NIH的目标，即研究营养因素在因果关系或预防CHF方面的作用。 这项拟议的研究的结果将与公共卫生高度相关，确定可能影响老年人主要疾病终点的风险，包括心力衰竭，房颤，中风和死亡。