Nebraska Center for Integrated Biomolecular Communication (CIBC)

内布拉斯加州综合生物分子通讯中心 (CIBC)

• 批准号: 9330174
• 负责人: JAMES M TAKACS
• 金额: $ 225.06万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330174
• 关键词: Address; Advanced Development; Biochemistry; Bioinformatics; Biological Sciences; Biomedical Research; Cells; Centers of Research Excellence; Chemicals; Chemistry; Collaborations; Communication; Communication Research; Communities; Complex; Computer Simulation; Core Facility; Coupled; Data; Data Analyses; Development; Disease; Disease Pathway; Disease Progression; Engineering; Fostering; Goals; Human; Human Resources; Individual; Informatics; Interdisciplinary Study; International; Kinetics; Knowledge; Lead; Ligands; Liver; Liver diseases; Mass Spectrum Analysis; Metabolic; Metabolic Pathway; Metagenomics; Methodology; Methods; Microscopy; Molecular; Molecular Probes; Mutation; NMR Spectroscopy; Nature; Nebraska; Organism; Outcome; Pathway interactions; Phosphorylation; Protein Analysis; Proteins; Proteomics; Regulation; Regulatory Pathway; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resolution; Science; Services; Signal Transduction; Stimulus; Structure; System; Systems Biology; Techniques; Technology; Tissue Engineering; Tissues; Universities; career development; cohort; data management; design; environmental chemical; improved; innovation; member; metabolomics; method development; microbial; nature center; new technology; next generation sequencing; novel; pathogen; protein profiling; public health relevance; rapid technique; research and development; response; success; technology development; temporal measurement; tool

 DESCRIPTION (provided by applicant): The University of Nebraska-Lincoln (UNL) seeks to foster collaborative interdisciplinary research to enhance its biomedical research infrastructure in the molecular life sciences. Building on the success of two prior UNL Centers of Biomedical Research Excellence (COBREs), it is proposed to establish the Nebraska Center for Integrated Biomolecular Communication (CIBC). The proper regulation of biomolecular communication pathways is critical to maintaining healthy function, yet there are many gaps in the fundamental understanding of those pathways. Unraveling those pathways and filling in critical knowledge gaps requires the combined expertise of collaborative, interdisciplinary research teams. CIBC's long-term goal is to foster the development of collaborative research teams with broad disciplinary representation to interrogate complex disease pathways, especially by connecting researchers who are developing new molecular probes and analytical techniques with those unravelling molecular mechanisms of complex diseases. CIBC's Specific Aims are to: 1) Support the research and career development of early stage investigators whose research is broadly focused on understanding the regulation of biomolecular communication pathways; 2) Leverage existing facilities and enhance research capabilities by establishing a Systems Biology Core and a Data Management and Analysis Core; and 3) Foster the development of integrated interdisciplinary research collaborations with diverse disciplinary representation to pursue high impact biomedical research. The initial cohort of project leaders - five early stage investigators from the Departments of Biochemistry, Chemistry, and Chemical and Biomolecular Engineering - are pursuing projects interrelated by their fundamental focus on different aspects of biomolecular communication within and between cells and tissues. These projects are directed toward identifying molecular metabolic signals of microbial syntrophy in the human gut, developing techniques for high-resolution protein glycoform analysis, unraveling ligand-Stabilin-2 interactions in liver disease progression, designing molecular probes for intracellular phosphorylation kinetics, and developing tissue engineering platforms specifically for liver. The breadth of science encompassed by these projects signifies the interdisciplinary nature of the Center's research goals. CIBC's proposed Systems Biology Core and Data Management and Analysis Core facilities leverage existing core facilities established under prior COBRE support. The proposed research cores, coupled with the interdisciplinary focus of the CIBC, will serve as a natural mixing chamber to foster the development of new collaborations among Nebraska's biomedical researchers to pursue high impact biomedical research. CIBC's innovation is in integrating the research activities of chemists, biochemists, engineers, and bioinformaticists. Its impact will be in addressing critical knowledge gaps in the understanding of how cells communicate and integrate metabolic and regulatory pathways relevant to disease development and progression.

 描述（由申请人提供）：内布拉斯加大学林肯分校 (UNL) 力求以内布拉斯加大学林肯分校之前两个生物医学研究卓越中心 (COBRE) 的成功为基础，促进跨学科合作研究，以增强其在分子生命科学领域的生物医学研究基础设施。 ，建议建立内布拉斯加州综合生物分子通讯中心（CIBC）。生物分子通讯途径的适当调节对于维持健康功能至关重要，但对这些的基本理解还存在许多差距。阐明这些途径并填补关键的知识空白需要协作、跨学科研究团队的综合专业知识，CIBC 的长期目标是促进具有广泛学科代表性的协作研究团队的发展，特别是通过连接研究人员。 CIBC 的具体目标是： 1) 支持早期研究人员的研究和职业发展，他们的研究主要集中于了解疾病的调控。生物分子通讯途径；2) 通过建立系统生物学核心和数据管理和分析核心，利用现有设施并增强研究能力；3) 促进与不同学科代表性的综合跨学科研究合作的发展，以开展高影响力的初步生物医学研究。项目领导者队伍——来自生物化学、化学、化学和生物分子工程系的五名早期研究人员——正在开展相互关联的项目，他们的基本重点是细胞内和细胞间生物分子通讯的不同方面，这些项目旨在识别人类肠道微生物综合症的分子代谢信号，开发高分辨率蛋白质糖型分析技术，揭示肝脏疾病进展中的配体-Stabilin-2相互作用，设计细胞内磷酸化动力学的分子探针，以及开发专门针对肝脏的组织工程平台，这些项目所涵盖的科学广度表明了 CIBC 提议的系统生物学核心和数据管理和分析核心设施的跨学科性质。拟议的研究核心，加上 CIBC 的跨学科重点，将作为一个自然的混合室，促进内布拉斯加州生物医学研究人员之间新合作的发展，以追求 CIBC 的高影响力生物医学创新。整合化学家、生物化学家、工程师和生物信息学家的研究活动。 影响将在于解决在理解细胞如何通讯以及与疾病发生和进展相关的代谢和调节途径方面的关键知识差距。