SERVICES FOR THE CHARACTERIZATION OF ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION, AND TOXICITY (ADMET) PROPERTIES OF SMALL-MOLECULE DRUG CANDIDATES USING STANDARDIZED IN VITRO METHODS IN SUPPORT O

使用标准化体外方法表征小分子候选药物的吸收、分布、代谢、排泄和毒性 (ADMET) 特性的服务

• 批准号: 10936131
• 负责人: RALF GEIBEN LYNN
• 金额: $ 5.63万
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2024-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10936131
• 关键词: Adverse effects; Animals; Behavior; Biological; Biological Assay; Cells; Chemicals; Contracts; Data; Development; Drug Kinetics; Enzymes; Excretory function; Human; In Vitro; Metabolism; Methods; Molecular; Permeability; Pharmaceutical Preparations; Phase; Process; Property; Services; Solubility; Standardization; Testing; Time; Tissues; Toxic effect; absorption; analog; behavior prediction; clinical candidate; design; drug candidate; drug development; drug discovery; experimental study; in vitro Assay; in vivo; lead candidate; novel; programs; small molecule

The purpose of this contract is to determine in vitro ADMET (absorption, distribution, metabolism, excretion, toxicity) in two novel compounds using molecular methods. These experiments will help determine the drug-like properties of these novel compounds and their suitability for further development.

该合同的目的是利用分子方法测定两种新型化合物的体外 ADMET（吸收、分布、代谢、排泄、毒性）。这些实验将有助于确定这些新型化合物的类药特性及其进一步开发的适用性。