Point-of-Care Electrochemical Aptasensor for Long-Term Pharmacological Adherence Monitoring

用于长期药理学依从性监测的护理点电化学适体传感器

• 批准号: 10927085
• 负责人: MATTHEW SMIECHOWSKI
• 金额: $ 30万
• 依托单位: GUILD ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10927085
• 关键词: Adherence; Binding; Biological; Biological Assay; Biosensor; Blood; Blood specimen; Contracts; Detection; Devices; Drug resistance; Goals; HIV; HIV drug resistance; Monitor; Pharmaceutical Preparations; Plasma; Sampling; Time; Urine; Viral Load result; Whole Blood; aptamer; cost; electric impedance; novel; pharmacologic; point of care; pre-exposure prophylaxis; programs; sensor

Point-of-Care HIV Viral Load, Drug Resistance, and Adherence Assays: The long-term goals of this program are to develop novel, low-cost, real-time point-of-care (POC) assays for 1. HIV Viral Load Monitoring; 2. HIV Drug Resistance Monitoring; and 3. Pharmacological Adherence Monitoring. This contract aims to develop an electrochemical aptamer-based sensor device for simple, rapid, and low-cost detection and quantification of Pre-Exposure Prophylaxis (PrEP) drugs in urine and blood samples at the point-of-care (POC).

护理点 HIV 病毒载量、耐药性和依从性检测：该计划的长期目标是开发新颖、低成本、实时护理点 (POC) 检测，用于 1. HIV 病毒负载监控； 2. HIV耐药性监测； 3. 药理学依从性监测。该合同旨在开发一种基于电化学适体的传感器装置，用于在护理点 (POC) 中简单、快速、低成本地检测和定量尿液和血液样本中的暴露前预防 (PrEP) 药物。