The impact of early-life nutrition on socioeconomic status, physical health and cognitive function through middle age

早期营养对中年社会经济地位、身体健康和认知功能的影响

• 批准号: 10564634
• 负责人: JERE R BEHRMAN
• 金额: $ 59.54万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-15 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10564634
• 关键词: Adult; Affect; Age; Age Years; Age-associated memory impairment; Aging; Animal Experimentation; Anthropometry; Behavior; Biological Aging; Biological Markers; Biology; Birth Weight; Capital; Central America; Child; Child Health; Childhood; Chronic Disease; Cognition; Cognitive; Cognitive aging; Collaborations; Data; Data Collection; Dietary Intervention; Dimensions; Economics; Effectiveness; Elderly; Energy Intake; Family; Female; First Births; Future; Guatemalan; Hand Strength; Health; Height; Human; Impaired cognition; Income; Individual; International; Intervention; Investments; Knowledge; Length; Life; Life Cycle Stages; Link; Literature; Liver diseases; Longevity; Malnutrition; Marketing; Measures; Modeling; Nutritional; Nutritional Study; Nutritional status; Only Child; Outcome; Panama; Participant; Personal Satisfaction; Persons; Play; Population; Pregnancy; Premature aging syndrome; Productivity; Public Health; Qualifying; Research; Risk; Role; Schools; Sensory; Socioeconomic Status; Strategic Planning; Stress; Supplementation; Time; United States National Institutes of Health; Wages; Work; age related; aging brain; cognitive function; cognitive skill; cohort; early childhood; early-life nutrition; econometrics; economic outcome; executive function; fitness; follow-up; healthy aging; human capital; improved; innovation; inter-institutional; low and middle-income countries; male; member; middle age; mortality; next generation; nutrition; nutritional supplementation; physical conditioning; productivity loss; programs; protein intake; psychologic; sex; socioeconomics; young adult

PROJECT SUMMARY Nutrition is a key human capital investment, especially in low- and middle-income countries (LMICs), where hundreds of millions of children are currently undernourished and well over a billion adults were undernourished as children. Prior evidence indicates that early-life undernutrition is associated with negative effects on physical health, schooling attainment, cognitive skills and wage rates in young adulthood. Given that physical health and cognitive function decline with age, it is important to ask whether early-life nutrition affects the pace of these declines. This is a critical knowledge gap concerning the lifespan impacts of early-life nutrition. This project will use unusually rich longitudinal data from an experimental manipulation of nutrition: the Guatemalan Institute of Nutrition of Central America and Panama (INCAP) Nutrition Supplementation Trial Cohort (INSTC). INSTC was initiated in 1969 as an experimental nutritional-supplementation program and a number of follow-up rounds have been conducted. Cohort members will be in mature adulthood, 47-64 years of age, during the proposed project, ages at which biological and cognitive aging is considerable in most LMICs. Specifically, the project will explore how experimentally allocated early-life nutritional supplementation affects levels of socioeconomic, physical-health, and cognitive-function outcomes in mature adulthood (47-64 y) and changes in these domains from early to mature adulthood. We ask: Do the nutrition intervention impacts observed earlier in adulthood persist at later ages? Does improved childhood nutrition additionally impact changes in these outcomes as participants age? We will explore these questions by collecting and analyzing a comprehensive set of measures of socioeconomic status, physical health and cognitive function, many of which we have measures in prior waves. The proposed study has high potential impact because of the enormous consequences of childhood undernutrition for the health and human capital of hundreds of millions of people. The research team is uniquely well qualified to investigate this topic; team members have made major contributions to current knowledge about the importance of nutrition over the life-course in LMICs. By using appropriate econometrics and life-cycle human capital models, with full access to the early childhood data, and building on previous studies, the project will transform our understanding of early-life nutrition and the health, cognitive and socioeconomic outcomes of mature adulthood.

项目摘要 营养是主要的人力资本投资，尤其是在低收入和中等收入国家（LMIC）的地方，那里 目前有数亿儿童营养不良，超过十亿成人营养不良 小时候。先前的证据表明，早期寿命不足与对身体的负面影响有关 成年后的健康，学业成就，认知技能和工资率。鉴于身体健康和 认知功能随着年龄的增长而下降，重要的是要询问早期生活的营养是否会影响这些速度 下降。这是关于早期营养的寿命影响的关键知识差距。这个项目将 使用营养实验操作的异常丰富的纵向数据：危地马拉研究所 中美洲和巴拿马（INCAP）营养补充试验同类（Instc）的营养。 Instc是 于1969年作为实验性营养补给计划启动，许多后续回合具有 已进行。在拟议的项目期间 在大多数LMIC中，生物学和认知衰老的年龄是相当大的。 具体而言，该项目将探讨实验分配的早期营养补充如何影响 成年后的社会经济，身体健康和认知功能结果的水平（47-64 y）和 这些领域的变化从早期到成熟的成年。我们问：营养干预会影响 在成年期早些时候观察到后来？改善了儿童营养的其他影响 随着参与者的年龄，这些结果的变化？我们将通过收集和分析 全面的社会经济地位，身体健康和认知功能的衡量标准，其中许多 我们在先前的波浪中采取了措施。 拟议的研究由于童年的巨大后果而具有很大的潜在影响 营养不良的卫生和人力资本不足。研究团队是独特的 有资格调查这个主题；团队成员为当前知识做出了重大贡献 营养对LMIC的生命过程的重要性。通过使用适当的计量经济学和生命周期人类 资本模型，充分访问幼儿数据，并在先前的研究中进行建设，该项目将 改变我们对早期营养以及健康，认知和社会经济结果的理解 成熟的成年。