Health Opportunities & Promoters of Equitable Screening for Lung Cancer (Hopes for Lung Cancer)

健康机会

基本信息

批准号：
10591639
负责人：
Efren Flores
金额：
$ 28.08万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-03 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10591639
关键词：
Address Area Award Awareness COVID-19 Cancer Etiology Charge Clinic Clinical Collaborations Communities Community Health Community Networks Data Dedications Development Plans Disclosure Disparity Documentation Early Diagnosis Education Education and Outreach Educational Intervention Electronic Health Record Electronic Mail Elements Eligibility Determination Environment Equity Focus Groups Foundations Fright Guidelines Health Healthcare Systems Hispanic Hispanic Populations Hospitals Individual Institution Intervention K-Series Research Career Programs Leadership Malignant neoplasm of lung Mental Health Mentors Mentorship Methods Modality Modeling National Institute on Minority Health and Health Disparities Not Hispanic or Latino Outcome Participant Patient Participation Patients Physicians Population Positioning Attribute Provider Publishing Radiology Specialty Research Research Personnel Resources Schedule Scientist Smoker Smoking Status Surveys Text Messaging Theoretical model Training Training Support Underserved Population United States Preventative Services Task Force Vulnerable Populations Work acceptability and feasibility cancer health disparity cancer survival career career development community based participatory research community partnership cost digital delivery digital health digital intervention evidence base experience former smoker health record hispanic community improved innovation interest intervention delivery intervention effect low socioeconomic status lung basal segment lung cancer screening mortality novel outreach patient portal pilot trial prevent promoter research study satisfaction screening guidelines screening participation severe mental illness smoking cessation social culture trial enrollment uptake

项目摘要

PROJECT SUMMARY Candidate: This resubmission for the NCI K08 Mentored Clinical Scientist Research Career Development Award to Promote Diversity describes Efrén J. Flores, MD as a candidate who is well- positioned to successfully complete the proposed training objectives and research aims. Dr. Flores’ background as a Hispanic physician and clinical researcher has focused on achieving equity in lung cancer outcomes through early detection by developing novel interventions to increase LCS uptake among Hispanic and othervulnerable populations. Background: Lung cancer remains the leading cause of cancer-specific mortality in theUS, and Hispanics experience worse lung cancer outcomes and die at higher rates due to advanced stage at presentation. Lung cancer screening (LCS) can save many lives through early lung cancer detection among Hispanic current and former smokers. Still, without increasing efforts to improve smoking status disclosure and documentation and tailored interventions to promote LCS uptake among Hispanic current and former smokers, this underserved population will continue to demonstrate disparities in lung cancer survival. Study aims: Based on prior research experience, Dr. Flores has adapted the NIMHD research framework by incorporating elements from Ford’s evidence-based theoretical model to guide the following proposed study aims: 1) To elucidate barriers and facilitators to consistent identification and documentation of smoking status to promote LCS uptake among Hispanic current and former smokers; 2) To assess feasibility, acceptability, and reach of the digital delivery of an educational video to promote LCS uptake among Hispanic current and former smokers; 3) To explore the effect of the digital delivery of the educational video to increase interest, intent, and scheduling of LCS uptake among Hispanic current and former smokers. Training: The career development plan will allow Dr. Flores to develop expertise in tailoring LCS interventions among Hispanic communities by completing training objectives in three areas: 1) mixed methods to inform health interventions; 2) community-based participatory research to guide outreach interventions; 3) digital interventions tailored to promote LCS uptake among Hispanic communities. Advanced coursework, a resource-rich institutional environment, and the proposed research study will support these training objectives. Mentorship: A team of expert mentors, including Dr. Elyse R. Park (primary mentor),Dr. Ruth C. Carlos (co-mentor), and Dr. Kelly E Irwin (co-mentor), and scientific advisors including Dr. Jennifer Haas, Dr. Nancy Rigotti, Dr. Giselle Perez, Dr. Jo-Anne Shepard, Dr. Joseph Betancourt, and Dr. Nathaniel Mercaldo will guide Dr. Flores’ training and research efforts for the duration of the award. Impact: The successfulcompletion of this proposed K08 award will provide Dr. Flores with the rigorous training and research expertise that will provide high-quality data to inform an NCI R01. It will also serve as a foundation for him to become a leading independent investigator developing novel interventions to overcome disparities and advance equity in lung cancer outcomes among Hispanics and other vulnerable populations.

项目概要候选人：NCI K08 指导临床科学家研究生涯的重新提交促进多元化发展奖将 Efrén J. Flores 医学博士描述为一位候选人，他非常擅长：旨在成功完成弗洛雷斯博士提出的培训目标和研究目标。作为西班牙裔医生和临床研究人员的背景专注于实现肺的公平通过开发新的干预措施来增加 LCS 的摄取，通过早期检测来改善癌症结果背景：肺癌仍然是最主要的癌症。导致美国癌症特异性死亡的原因，而西班牙裔人的肺癌结果更差由于肺癌筛查 (LCS) 已处于晚期，死亡率会更高。通过对西班牙裔当前和以前吸烟者进行早期肺癌检测，挽救许多生命。尽管如此，仍然没有加大努力改善吸烟状况的披露和记录以及量身定制旨在促进西班牙裔当前和以前吸烟者对 LCS 的吸收的干预措施，但服务不足人群将继续表现出肺癌生存率的差异研究目标：基于先前的研究。根据研究经验，弗洛雷斯博士通过纳入 NIMHD 研究框架来调整福特基于证据的理论模型的要素来指导以下拟议的研究目标： 1) 阐明一致的吸烟识别和记录的障碍和促进因素促进西班牙裔当前和以前吸烟者采用 LCS 的状况 2) 评估可行性，教育视频数字化传播的可接受性和影响力，以促进 LCS 的普及 3）探索数字化教育教学的效果旨在提高拉美裔现任和前任人士对濒海战斗舰的兴趣、意图和安排的视频培训：职业发展计划将使弗洛雷斯博士能够发展裁缝方面的专业知识。 LCS 通过完成三个领域的培训目标对西班牙裔社区进行干预：1) 混合方法为健康干预措施提供信息；2）以社区为基础的参与性研究来指导外展干预措施；3) 旨在促进西班牙裔人接受 LCS 的数字干预措施先进的课程、资源丰富的制度环境以及拟议的社区。研究将支持这些培训目标：专家导师团队，包括 Elyse R. Park 博士（主要导师）、Ruth C. Carlos 博士（共同导师）和 Kelly E Irwin 博士（共同导师）和科学顾问，包括 Jennifer Haas 博士、Nancy Rigotti 博士、Giselle Perez 博士、 Jo-Anne Shepard 博士、Joseph Betancourt 博士和 Nathaniel Mercaldo 博士将指导 Flores 博士的治疗获奖期间的培训和研究工作影响：成功完成此任务。拟定的 K08 奖项将为弗洛雷斯博士提供严格的培训和研究专业知识，提供高质量的数据来告知NCI R01，这也将成为他成为NCI R01的基础。一位领先的独立调查员开发新颖的干预措施来克服差异和西班牙裔进步人士和其他弱势群体之间肺癌结果的公平性。