The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child Health

ECHO 测量核心：评估环境暴露和儿童健康的框架和资源

• 批准号: 10744676
• 负责人: DAVID CELLA
• 金额: $ 350万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2030-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744676
• 关键词: Adoption; Adult; Brain; Child Development; Child Health; Clinical Research; Cohort Studies; Collaborations; Collection; Communication; Computers; Conceptions; Data; Data Analyses; Data Collection; Data Element; Decision Making; Dedications; Detection; Development; Developmental Process; Disease; Ensure; Environmental Exposure; Environmental Risk Factor; Foundations; Goals; Health; Investigation; Lead; Link; Longevity; Manuals; Maps; Measurement; Measures; Methods; Monitor; Obesity; Outcome; Participant; Perinatal Exposure; Personal Satisfaction; Persons; Population Heterogeneity; Predisposition; Procedures; Process; Protocols documentation; Psychometrics; Public Health; Publications; Reproducibility; Resources; Respondent; Risk; Science; Scientist; Shapes; Site; Specific qualifier value; Standardization; Structure; Support System; System; Technology; Testing; Time; Training; Visit; Work; cohort; data harmonization; flexibility; implementation fidelity; implementation strategy; improved; innovation; instrument; mindfulness; neurodevelopment; novel; participant retention; postnatal; preclinical study; remote assessment; sound; standardize measure; wearable sensor technology

Environmental exposures profoundly shape lifespan health and disease trajectories. Preconception and pre- perinatal exposure can permanently alter the developing brain and associated regulatory systems to increase susceptibility to a host of diseases and developmental challenges. Protective and promotive environmental factors can promote well-being, even amidst adversity. The ECHO Consortium of Cohort Study Sites, Cores, and Centers is dedicated to mapping the impact of early exposures on child health and development. Good science depends on good measurement. Our proposed ECHO Measurement Core will advise, orchestrate, and frame the coordinated, sensitive measurement of exposures, developmental processes, and health outcomes central to achieving ECHO's objective. We propose three aims. Aim 1 is to develop and refine measures for the ECHO Cohort Protocol (ECP), including methods to implement the measures. We will lead efforts to optimize the measurement of exposures and outcomes, mindful of best measurement practices as well as respondent and staff burden. We will lead the timely development of a preconception section for the Protocol by drawing on diverse expertise across the ECHO Network to ensure feasible, robust, and culturally sensitive assessment of critical data elements in the preconception period that have direct import for the primary ECHO child health outcomes (pre-, peri-, post-natal, airways, obesity, neurodevelopment, and positive health). We will leverage novel psychometric and technological methods such as computer adaptive tests, wearable sensors, and other innovations in remote assessment, to reduce barriers to study participation and enhance participant retention. Aim 2 is to assist the ECHO Consortium in implementing and evaluating the ECP. We will further collaborate with everyone in the Consortium to finalize the protocol and establish a standard implementation strategy that can be implemented across the diverse Cohort Study Sites, including determining optimal study visit structure and choreography, developing Manual(s) of Operating Procedures (MOPs), and creating, supporting, and, when appropriate, leading training. Aim 3 is to lead strategic decision-making and operational strategies to incorporate new and revised measures to advance ECHO Cohort science while minimizing participant and staff burden. We propose to optimize measurement decisions by maintaining collaborative communication, rapidly deploying data and biospecimen collection for time-sensitive needs, identifying and evaluating important measurement developments, creating a technology pipeline for rapid adoption of innovative approaches to data collection, and ensuring data collection strategies are validated for diverse populations. Our measurement science expertise within and outside of ECHO, paired with our participant-centered approach, enables us to bridge reliable and valid assessment with practical feasibility and ultimately allows us to bring ECHO scientists together toward our shared goal of mapping the impact of early exposures on child health and development.

环境暴露会深刻塑造寿命健康和疾病轨迹。先入为主和前 围产期暴露可以永久改变发展的大脑和相关的调节系统以增加 对许多疾病和发展挑战的敏感性。保护性和促进性环境 因素可以促进幸福感，甚至在逆境中。队列研究地点的回声联盟，核心， 中心致力于绘制早期暴露对儿童健康和发育的影响。好的 科学取决于良好的测量。我们提出的回声测量核心将建议，编排和 构建对暴露，发育过程和健康结果的协调，敏感的测量 实现Echo目标的核心。我们提出了三个目标。目标1是制定和完善 回声队列协议（ECP），包括实施措施的方法。我们将领导优化的努力 衡量暴露和结果的测量，请注意最佳测量实践以及受访者 和员工负担。我们将通过利用 在回声网络上的多样化专业知识，以确保可行，健壮和对文化敏感的评估 在预想时期的关键数据要素直接导入主要回声儿童健康 结局（前，周期，产后，气道，肥胖，神经发育和阳性健康）。我们将利用 新颖的心理测量和技术方法，例如计算机自适应测试，可穿戴传感器和其他 远程评估中的创新，以减少研究参与的障碍并增强参与者的保留。 AIM 2是协助回声联盟实施和评估ECP。我们将进一步合作 财团中的每个人都可以完成协议并建立标准实施策略 可以在各种队列研究网站上实施，包括确定最佳研究访问结构 和编排，开发操作程序（MOP）的手册，以及创建，支持，以及 适当的领导培训。目标3是领导战略决策和运营策略以纳入 新的和修订的措施，以推进回声队列科学，同时最大程度地减少参与者和员工负担。我们 建议通过维持协作沟通，快速部署数据来优化测量决策 以及针对时间敏感需求的生物测量收集，识别和评估重要的测量 发展，创建技术管道，以快速采用创新方法来收集数据，并 确保数据收集策略已被验证为不同的人群。我们的测量科学专业知识 在Echo内外，与我们以参与者为中心的方法配对，使我们能够桥接可靠和 具有实际可行性的有效评估，并最终使我们能够将回声科学家融合到我们的 绘制早期暴露对儿童健康和发育的影响的共同目标。

项目成果

A short form of the Crisis in Family Systems (CRISYS) in a racially diverse sample of pregnant women.

• DOI: 10.1007/s12144-021-02335-w
• 发表时间: 2023
• 期刊: CURRENT PSYCHOLOGY
• 影响因子: 2.8
• 作者: Sherlock, Phillip;Shalowitz, Madeleine U;Berry, Carolyn;Cella, David;Blackwell, Courtney K;Cowell, Whitney;Rodriguez, Karen M Reyes;Wright, Rosalind J
• 通讯作者: Wright, Rosalind J

Measurement bias in caregiver-report of early childhood behavior problems across demographic factors in an ECHO-wide diverse sample.

在 ECHO 范围内的多样化样本中，不同人口因素的儿童早期行为问题的照顾者报告中存在测量偏差。

• DOI: 10.1002/jcv2.12198
• 发表时间: 2024
• 期刊: JCPP advances
• 作者: Zheng,Shuting;Mansolf,Maxwell;McGrath,Monica;Churchill,MarieL;Bekelman,TraciA;Brennan,PatriciaA;Margolis,AmyE;Nozadi,SaraS;Bastain,TheresaM;Elliott,AmyJ;LeWinn,KajaZ;Hofheimer,JulieA;Leve,LeslieD;Rennie,Brandon;Zimmer
• 通讯作者: Zimmer

Linking the Child Behavior Checklist to the Strengths and Difficulties Questionnaire.

• DOI: 10.1037/pas0001083
• 发表时间: 2022-03
• 期刊: PSYCHOLOGICAL ASSESSMENT
• 影响因子: 3.6
• 作者: Mansolf, Maxwell;Blackwell, Courtney K;Cummings, Peter;Choi, Seohyun;Cella, David
• 通讯作者: Cella, David

Prerequisite Skills in Cognitive Testing: Innovations in theory and recommendations for practice.

认知测试的必备技能：理论创新和实践建议。

• DOI: 10.1016/j.cogdev.2021.101038
• 发表时间: 2021
• 期刊: Cognitive development
• 影响因子: 1.8
• 作者: Kaat,AaronJ;Bishop,Somer;Condy,Emma;Sullivan,NancyR;Soorya,Latha;Thurm,Audrey
• 通讯作者: Thurm,Audrey

Assessing the interchangeability of linked scores in multivariable statistical analyses.

评估多变量统计分析中关联分数的互换性。

• DOI: 10.1007/s11136-023-03592-x
• 发表时间: 2024
• 期刊: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
• 作者: Mansolf,Maxwell;Blackwell,CourtneyK;Cella,David;Lai,Jin-Shei
• 通讯作者: Lai,Jin-Shei