ShEEP Request for MagVenture rTMS machine with EEG and fMRI synchronization

ShEEP 请求配备 EEG 和 fMRI 同步功能的 MagVenture rTMS 机器

• 批准号: 10740832
• 负责人: Elizabeth W Twamley
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10740832
• 关键词: Acceleration; Brain; California; Charge; Clinic; Clinical; Clinical Protocols; Clinical Research; Clinical Services; Clinical Trials; Cognitive; Collection; Dedications; Devices; Electroencephalography; Emergency Situation; Emotional; Equipment; Extravasation; FDA approved; Frequencies; Functional Magnetic Resonance Imaging; Funding; Grant; Intervention; Investigation; K-Series Research Career Programs; Link; Magnetic Resonance Imaging; Magnetism; Major Depressive Disorder; Medical center; Mental Depression; Mental Health; Mental disorders; Modification; Monitor; Morphologic artifacts; Names; Neurons; Obsessive-Compulsive Disorder; Peripheral Nervous System; Phase; Physician Executives; Physiologic pulse; Post-Traumatic Stress Disorders; Principal Investigator; Process; Program Evaluation; Research; Research Personnel; Research Project Grants; Resources; Schizophrenia; Stress; System; Techniques; Transcranial magnetic stimulation; Translational Research; Trauma; Traumatic Brain Injury; Veterans; chronic pain; cognitive neuroscience; design; experience; experimental study; improved; improved outcome; interest; magnetic field; neuroimaging; neuromechanism; neurophysiology; programs; remote control; research and development; research study; tool

Project Summary / Abstract For this Office of Research Development Shared Equipment Evaluation Program (ShEEP) proposal, we are requesting a Transcranial Magnetic Stimulation (TMS) device with functional magnetic stimulation (fMRI) and electroencephalogram (EEG) integration as a shared-equipment resource to be used primarily for mental health research on posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), depression, schizophrenia, and chronic pain. The requested TMS device is state-of-the- art and capable of delivering brief pulses of high alternating magnetic fields. TMS is an essential tool for cognitive/translational neuroscientific investigations and also used to induce long-term plasticity and improve outcomes in clinical interventions. TMS is currently FDA approved to treat major depression and obsessive-compulsive disorder, and there are many clinical trials ongoing for multiple other conditions. At the Jennifer Moreno VA Medical Center (JMVAMC), there are several TMS devices, but all are dedicated primarily for clinical services and almost entirely occupied at present. Moreover, these devices are optimized for the FDA-approved treatments and do not have all of the capabilities typically required for research-based investigations. The advanced features of the device we are requesting include fMRI and EEG compatibility and the ability to perform high-frequency (i.e., theta- burst-stimulation) high-power pulses. This device also comes with the full assortment of accessories (coil, seating chair, coil holder, and the full assortment of MRI-safe equipment) required to perform the studies outlined in the Research Plan. With this device, there are a number of current and future research projects that would be facilitated, including basic cognitive neuroscience investigations into neural mechanisms underlying PTSD and TBI and clinical/translational research in several mental health disorders, including PTSD, TBI, depression, schizophrenia and chronic pain. This device has the potential to accelerate clinical research at JMVAMC across a wide-variety of PIs and research projects focused on mental health and related conditions.

项目概要/摘要 对于研究发展办公室共享设备评估计划 (ShEEP) 提案， 我们正在请求具有功能性磁力的经颅磁刺激 (TMS) 设备 刺激（fMRI）和脑电图（EEG）集成作为共享设备资源 主要用于创伤后应激障碍（PTSD）、创伤性脑部的心理健康研究 损伤（TBI）、抑郁症、精神分裂症和慢性疼痛。所请求的 TMS 设备是最新的 技术并能够传递高交变磁场的短暂脉冲。 TMS是必不可少的工具 用于认知/翻译神经科学研究，也用于诱导长期可塑性 并改善临床干预的结果。 TMS 目前已获得 FDA 批准用于治疗重大疾病 抑郁症和强迫症，并且有许多临床试验正在进行中 其他条件。 在 Jennifer Moreno VA 医疗中心 (JMVAMC)，有几台 TMS 设备，但全部都是 主要用于临床服务，目前几乎全部被占用。而且，这些 设备针对 FDA 批准的治疗进行了优化，但不具备所有功能 通常需要基于研究的调查。我们设备的先进功能 要求包括功能磁共振成像和脑电图兼容性以及执行高频的能力（即，theta- 突发刺激）高功率脉冲。该设备还配备了齐全的配件 执行所需的（线圈、座椅、线圈支架以及全套 MRI 安全设备） 研究计划中概述的研究。 有了这个设备，可以促进许多当前和未来的研究项目， 包括对 PTSD 背后神经机制的基本认知神经科学研究 TBI 和多种精神健康疾病的临床/转化研究，包括 PTSD、TBI、 抑郁症、精神分裂症和慢性疼痛。该设备有可能加速临床 JMVAMC 的研究涉及各种 PI 和专注于心理健康的研究项目 及相关条件。