ShEEP Request for Assuring Research Reproducibility with an Integrated Sample and Data Management System

ShEEP 要求通过集成样本和数据管理系统确保研究的可重复性

• 批准号: 9796662
• 负责人: Edward N Janoff
• 金额: --
• 依托单位: VA EASTERN COLORADO HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9796662
• 关键词: Address; Affect; Aging; Agonist; Award; Awareness; Back; Basic Science; Biological Assay; Blood; California; Clinical; Clinical Research; Code; Coupled; Custom; Data; Data Analytics; Development; Doctor of Philosophy; Documentation; Enzymes; Equipment; Ethanol; Event; Excision; Expression Profiling; Freezing; Funding; Glass; Goals; HIV-1; Hand; Handwriting; Histology; Individual; Industry Standard; Infrastructure; Ink; International; Journals; K-Series Research Career Programs; Kynurenine; Label; Laboratories; Leg; Life; Link; Literature; Malignant neoplasm of lung; Management Information Systems; Medical; Meta-Analysis; Metadata; Methanol; Microscope; PPAR gamma; Pathway interactions; Plant Roots; Population; Prevention; Principal Investigator; Process; Productivity; Protocols documentation; Publishing; Reagent; Recording of previous events; Records; Regulation; Reporting; Reproducibility; Research; Research Personnel; Resistance; Risk; Risk Management; Sampling; Scanning; Science; Sheep; Site; Slide; System; Text; Toxoplasma; Translational Research; Trust; Tube; Tuberculosis; United States Food and Drug Administration; Variant; Veterans; Vial device; base; biobank; cancer chemoprevention; data management; design; experience; experimental study; falls; field study; flexibility; improved; instrument; laboratory equipment; mucosal vaccine; public trust; repository; response biomarker; suicidal behavior; user-friendly; vaccine response

In this application, we request the purchase of a comprehensive integrated sample and data management system, comprising a TubeWriter 360 printer and a FreezerWorks Laboratory Information Management System (LIMS). These instruments are flexible, versatile, and together they will substantially enhance the productivity and research capabilities of VA investigators. This system provides several key advantages for VA researchers. Overall, a laboratory printer in conjunction with a sophisticated but flexible and user-friendly LIMS will enhance research reproducibility and promote compliance with international standards for best research practices. This will be achieved by reduction in errors related to sample mislabeling, laboratory worker practice, and reagent or equipment variability, coupled with a comprehensive system for sample and data and metadata tracking. The TubeWriter 360 prints indelible ink on a wide variety of laboratory equipment, including plastic and glass containers of many sizes, and prints 1D and 2D barcodes in addition to text. The printer is fully integrated with the FreezerWorks LIMS, which easily tracks myriad data and metadata specific to a project in customizable workflows. Thousands of samples will be easily, uniquely, and correctly labeled and tracked throughout the life of a project, and metadata will be linked with analytical data for meta-analyses and self-audits. Based on these advantages, the following VA researchers and projects will benefit from the comprehensive integrated sample and data management system, comprised of the TubeWriter 360 and Freezerworks. 1. Edward Janoff, MD, Principal Investigator: CSR&D Merit Award “Impact of HIV -1 and Aging on Mucosal Vaccine Responses.” 2. Liron Caplan, MD, Principal Investigator: HSR&D Merit Award “Secondary Event Prevention using Population Risk Management After PCI.” 3. Robert Keith, MD, Principal Investigator: BLR&D Merit Award “PPAR Gamma Agonists for Lung Cancer Chemoprevention” 4. Lisa Brenner, PhD, local site investigator, CSR&D funded – “Toxoplasma Gondi, the Kynurenine Pathway, and Suicidal Behavior in Veterans” 5. Nicholas Walter, MD, PhD, Principal Investigator: CSR&D Career Development Award “Blood Expression Profiles as a Biomarker for Responses to Tuberculosis”

在此应用中，我们要求购买全面的集成样本和数据管理 系统，包括 TubeWriter 360 打印机和 FreezerWorks 实验室信息管理系统 (LIMS)。这些仪器灵活、通用，并且它们一起将大大提高生产力。 和 VA 研究人员的研究能力。 总体而言，该系统为 VA 研究人员提供了几个关键优势：实验室打印机。 拥有先进但灵活且用户友好的 LIMS 将提高研究的可重复性并促进 遵守最佳研究实践的国际标准将通过减少错误来实现。 与样品标签错误、实验室工作人员实践、试剂或设备变异性以及 用于样本、数据和元数据跟踪的综合系统 TubeWriter 360 可打印不可磨灭的墨水。 各种实验室设备，包括多种尺寸的塑料和玻璃容器，以及一维和 除文本外，打印机还与 FreezerWorks LIMS 完全集成，可轻松跟踪二维条形码。 数以千计的样品将很容易， 在项目的整个生命周期中进行独特且正确的标记和跟踪，并且元数据将与 用于荟萃分析和自我审核的分析数据。 基于这些优势，以下 VA 研究人员和项目将受益于全面的 集成样本和数据管理系统，由 TubeWriter 360 和 Freezerworks 组成。 1. Edward Janoff，医学博士，首席研究员：CSR&D 优异奖“HIV -1 和衰老对粘膜的影响” 疫苗反应。” 2. Liron Caplan，医学博士，首席研究员：HSR&D 优异奖“利用人口进行二次事件预防” PCI 后的风险管理。” 3. Robert Keith，医学博士，首席研究员：BLR&D 优异奖“PPAR γ 激动剂治疗肺癌” 化学预防” 4. Lisa Brenner 博士，当地现场调查员，CSR&D 资助 – “弓形虫，犬尿氨酸途径， 和退伍军人的自杀行为” 5. Nicholas Walter，医学博士、哲学博士、首席研究员：CSR&D 职业发展奖“血液表达” “作为应对结核病的生物标志物的概况”