ShEEP Request for Scintica Flow Velocity and Oxygen System

ShEEP 请求 Scintica 流速和氧气系统

• 批准号: 9794630
• 负责人: Hemal H Patel
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9794630
• 关键词: Acute; Address; Area; Award; Blood Flow Velocity; Blood Vessels; Blood flow; Brain; Brain Neoplasms; Collaborations; Coupled; Data; Data Analyses; Diabetes Mellitus; Disease; Echocardiography; Equipment; Erectile dysfunction; Fatty Liver; Fostering; Functional disorder; Funding; Health; Healthcare Systems; Heart; Heart failure; Homeostasis; Intervention; Kidney; Liver; Malignant Neoplasms; Measurement; Measures; Medical; Monitor; Mus; Muscle; Muscular Atrophy; Myocardial Ischemia; Neurodegenerative Disorders; Organ; Organism; Oryctolagus cuniculus; Oxygen; Pain; Pathology; Pharmacology; Physiologic pulse; Physiology; Population; Rattus; Research Personnel; Sheep; Structure; System; Techniques; Time; Tissues; Veterans; body system; burden of illness; clinical investigation; imaging modality; innovation; insight; interest; non-invasive imaging; novel; pre-clinical; resilience; response; sensor; tool

Project Summary/Abstract Medical techniques are widely used for pre-clinical investigations. These non-invasive imaging modalities are crucial for researchers to observe changes in organ/tissue structure, size, and blood flow during disease stages as well as in response to pharmacological interventions. The requested equipment is a system for flow velocity and oxygen measurement (Scintica Flow Velocity and Oxygen System) that will interface with our current echocardiographic system (Vevo3100, FUJIFILM, VisualSonics) funded previously by a ShEEP award for use in mice, rats, and rabbits. The Flow Velocity Oxygen System will be equipped with a real-time pulsed doppler acquisition and data analysis tool coupled to oxygen sensors that can measure tissue oxygen and oxygen flow and will allow a range of species to be used in conjunction with the current Vevo3100 echocardiographic system. As all organs are dependent on reliable blood flow and oxygen delivery and usage for proper function and that these aspects of homeostasis are often altered in various diseases states that impact the heart, brain, kidney, liver, and muscle, the blood flow and oxygen system will enhance the capabilities of multiple groups at the VA San Diego to assess these important parameters specific to their studies. The functionality of this novel Flow Velocity and Oxygen System will allow a large and prolific group of VA San Diego Healthcare System (VASDHS) investigators working in multiple systems the opportunity to expand their experimental capabilities dramatically and to foster new collaboration.

项目概要/摘要 医学技术广泛用于临床前研究。这些非侵入性成像 模式对于研究人员观察器官/组织结构、大小和血液的变化至关重要 在疾病阶段以及对药物干预的反应中流动。 所需设备是流速和氧气测量系统（Scintica Flow 速度和氧气系统）将与我们当前的超声心动图系统连接 （Vevo3100、FUJIFILM、VisualSonics）先前由 ShEEP 奖资助，用于小鼠、大鼠和 兔子。 流速氧气系统将配备实时脉冲多普勒采集和 与氧传感器耦合的数据分析工具，可以测量组织氧和氧流量， 将允许一系列物种与当前的 Vevo3100 超声心动图结合使用 系统。由于所有器官都依赖于可靠的血流和氧气输送以及正确使用 功能，并且体内平衡的这些方面经常在各种疾病中发生改变，表明 影响心脏、大脑、肾脏、肝脏和肌肉，血液流动和氧气系统会增强 弗吉尼亚州圣地亚哥多个团队评估这些重要参数的能力 他们的学习。 这种新颖的流速和氧气系统的功能将允许大量多产的 VA 圣地亚哥医疗系统 (VASDHS) 调查员在多个系统中工作 有机会大幅扩展他们的实验能力并促进新的合作。