Imaging Core

成像核心

基本信息

批准号：
10620686
负责人：
BRADFORD C DICKERSON
金额：
$ 24.3万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10620686
关键词：
Acceleration Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Amyloid Award Biological Markers Blood Vessels Classification Clinical Collaborations Communication Comparative Study Data Data Set Development Diagnosis Diagnostic Differential Diagnosis Early Diagnosis Early Onset Alzheimer Disease Education Ensure Evaluation Faculty Fiber Frontotemporal Lobar Degenerations Functional Magnetic Resonance Imaging Funding Future Goals Grant Heterogeneity Human Resources Image Image Analysis Individual Industry Inherited Injury International Intervention Trial Link Liquid substance MRI Scans Machine Learning Magnetic Resonance Imaging Massachusetts Measures Methods Mission Monitor Multi-Institutional Clinical Trial Multimodal Imaging Nerve Degeneration Outcome Participant Pattern Phenotype Positron-Emission Tomography Process Protocols documentation Radiopharmaceuticals Research Research Personnel Research Project Grants Resources Scanning Software Tools Students Syndrome Techniques Tissues Tracer Training United States National Institutes of Health Validation Work analytical method analytical tool biological research career cerebral atrophy clinical practice cohort connectome cost effective data tools disease heterogeneity image archival system imaging facilities imaging modality innovation interest multidisciplinary neuroimaging neuroimaging marker neuroinflammation neuropathology next generation novel preclinical study prognostication recruit research study tau Proteins vascular injury virtual white matter

项目摘要

Massachusetts Alzheimer's Disease Research Center: Imaging Core The Imaging Core of the Massachusetts Alzheimer's Disease Research Center (MADRC) supports and performs imaging research to understand a variety of types of heterogeneity in Alzheimer's disease and Alzheimer's disease related disorders (AD/ADRD) and accelerate progress towards a cure. We carry out core functions in Aims 1, 2, and 3 marshaling resources to enhance the research mission through the support and contributions to imaging components of MADRC-affiliated local and national research projects and the development of uniform imaging protocols that contribute to novel efforts to understand heterogeneity, such as the classification of MADRC Research Cohort participants into the "ATVN" (amyloid, tau, vascular, neurodegeneration) biological research framework. In Aims 4, 5, and 6, we develop and implement new strategies and accelerate progress towards a cure in our refinement and validation of novel PET and structural and functional MRI methods. These innovative imaging methods are evaluated in the MADRC Research Cohort, leveraging this deeply phenotyped cohort of participants spanning diverse AD/ADRD diagnoses to make the process of innovation cost-effective (many participants have already been imaged and so these measures can be used to facilitate strategic recruitment; e.g., of amyloid “positive” subjects) and value-added (by comparing novel imaging measures with those we understand well already). In Aims 7 and 8 we build the future by providing expertise, education, training and data and software tools to faculty, trainees and students for best practices in imaging research and by providing education to researchers, clinicians and the public on the advances, utility and responsible interpretation of imaging data in AD and ADRD research and ultimately clinical practice.

马萨诸塞州阿尔茨海默氏病研究中心：成像核心马萨诸塞州阿尔茨海默氏病研究中心（MADRC）的成像核心支持和进行成像研究以了解阿尔茨海默氏病和阿尔茨海默氏病有关的疾病（AD/ADRD），并加速了治愈的进步。我们执行目标1、2和3的核心功能通过对与MADRC相关的地方和国家研究项目的成像组成部分的支持和贡献以及统一成像方案的发展有助于理解异质性的新努力，这样随着MADRC研究队列参与者的分类为“ ATVN”（淀粉样蛋白，tau，血管，神经变性）生物学研究框架。在目标4、5和6中，我们开发和实施新的策略并加速进步，以治愈我们对新型宠物的改进和验证结构和功能性MRI方法。这些创新的成像方法在MADRC中进行了评估研究队列，利用了跨越潜水员广告/adrd的参与者的深层表型队列诊断以实现创新成本效益的过程（许多参与者已经成像，并且因此，这些措施可用于促进战略招聘；例如，淀粉样蛋白的“阳性”主体）和增值（通过将新颖的成像措施与我们已经很好理解的措施进行比较）。在目标7和8中我们通过为学员提供专业知识，教育，培训和数据以及软件工具来建立未来以及学生在成像研究方面的最佳实践，并通过向研究人员，临床医生和公众在AD和ADRD研究中对成像数据的进步，实用性和负责任的解释最终是临床实践。