Stationary Digital Tomosynthesis for Transbronchial Biopsy Guidance

用于经支气管活检指导的固定式数字断层合成

• 批准号: 10620615
• 负责人: Yueh Z Lee
• 金额: $ 71.16万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620615
• 关键词: Ablation; Animal Model; Animals; Area; Biopsy; Bronchoscopes; Bronchoscopy; Carbon Nanotubes; Cardiac ablation; Chest; Clinical; Code; Collaborations; Complication; Computer software; Computers; Development; Diagnosis; Diagnostic; Doctor of Philosophy; Dose; Early Diagnosis; Early treatment; Electromagnetics; Enhancing Lesion; Evaluation; Excision; Family suidae; Filtration; Goals; Image; Image-Guided Surgery; Intervention; Length of Stay; Lesion; Local Therapy; Location; Lung; Lung nodule; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Medical Imaging; Modality; Morbidity - disease rate; Motion; Needle biopsy procedure; Nodule; Operative Surgical Procedures; Performance; Peripheral; Positioning Attribute; Procedures; Productivity; Protocols documentation; Recovery; Reporting; Research; Research Personnel; Resolution; Risk; Roentgen Rays; Sampling; Scientist; Source; System; Systems Integration; Techniques; Technology; Three-Dimensional Image; Time; Travel; United States; Visualization; Visualization software; Work; X-Ray Computed Tomography; artificial lung; cancer diagnosis; cancer therapy; cost; detector; digital; image guided; image reconstruction; image registration; imaging approach; imaging system; improved; industry partner; instrument; instrumentation; interest; invention; lung cancer screening; lung lesion; lung visualization; medical complication; mortality; novel; phantom model; pre-clinical; radiologist; real-time images; screening program; stereoscopic; success; technology validation; tomosynthesis; tool; ultrasound

ABSTRACT The recent expansion of lung cancer screening programs in the United States has led to a significant increase in the number of lung lesions requiring sampling to evaluate their malignancy status. Bronchoscopic based peripheral lung biopsy offers the lowest rate of procedural complication. However, diagnostic yields have remained moderate, primarily due to the lack of high resolution, real-time imaging guidance. Techniques such as endobronchial ultrasound and electromagnetic navigational bronchoscopy offer some guidance for the interventionalist, but remain limited for the necessary fine localization of the biopsy needle tip and lesion just prior to sampling. Standard CT based imaging approaches are too expensive and cumbersome for intra- procedural use. We have developed a stationary digital chest tomosynthesis imaging approach based on the linear x-ray array based on the carbon nanotube field emission sources. Our approach offers the potential for rapid, high resolution in-plane imaging combined with low-dose stereoscopic imaging, all without the need for any physical motion of the x-ray source or detector. We seek to refine our stationary chest tomosynthesis system, evaluate rapid CT to tomosynthesis image registration techniques and integrate the software control and guidance system in a system for pre-clinical large animal evaluation. Our academic-industrial partnership will incorporate a team of physicists, computer scientists, radiologists and interventional pulmonologists to develop this system.

抽象的 美国最近在美国的肺癌筛查计划的扩大导致了大幅增长 在需要采样以评估其恶性状态的肺部病变数量中。基于支气管镜 外围肺活检提供的程序并发症率最低。但是，诊断产量有 仍然是温和的，这主要是由于缺乏高分辨率，实时成像指导。这样的技术 作为支气管内超声和电磁导航支气管镜检查， 介入主义者，但仍限制需要进行活检针头和病变的精细定位 在采样之前。基于标准CT的成像方法太昂贵且笨拙 程序用途。我们已经开发了一种基于 线性X射线阵列基于碳纳米管场发射源。我们的方法提供了潜力 快速，高分辨率的面内成像与低剂量立体成像结合在一起，无需 X射线源或检测器的任何物理运动。我们试图完善我们的固定胸部质膜 系统，评估快速的CT到层状图像登记技术并整合软件控制 和用于临床前大型动物评估系统中的指导系统。我们的学术工业合作伙伴关系 将结合一组物理学家，计算机科学家，放射科医生和介入肺科医生 开发此系统。