Chemistry Biology Interface Training Program

化学生物学界面培训计划

基本信息

批准号：
10620696
负责人：
Patrick G. Harran
金额：
$ 47.42万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10620696
关键词：
Biology Chemistry Training Programs

项目摘要

Project Summary The overall objective of the UCLA CBI Training Program is to educate a diverse group of scientists who will ethically lead rigorous research and training at the interface between chemistry and biology in the decades to come. Specifically, it is proposed that brilliant chemists who are amateurs in biology will be trained to identify and rigorously solve the most important problems in biology and be highly collaborative with biologists. Likewise, it is proposed that the biologist using a chemical technique as a black box will be converted into an expert who can identify new chemical approaches to solve their biological problems, and who are comfortable collaborating with chemists. The UCLA CBI Program provides this by breaking down the isolation between departments, and immersing trainees in state-of-the-art interdisciplinary research that spans the interface of chemistry and biology. The following specific aims are proposed: First, CBI will train graduate students in the language and techniques of research at the interface of chemistry and biology. Specifically, chemists will learn to be able to critically evaluate papers, be familiar with techniques and be able to rigorously discuss research topics in biology, and vice versa. Second, CBI will teach students the background to understand both the fundamentals and cutting edge research at the chemistry biology interface to enable them to distill this information in order to independently apply it to their own research and to develop new ideas. Third, CBI will enable students to hone their speaking skills and to work effectively in teams, especially with people in biology for chemists and vice versa. Fourth, the students will be instructed about ethical and responsible conduct of research so that they follow the ethical principals in their own research and hold these standards to others. Fifth, CBI trainees will be educated on the fundamentals of rigor and reproducibility in order to apply this to their own research and enable identification and interpretation of these factors in the work of others. Sixth and seventh, CBI will empower students to develop to their full potential professionally, providing them with all the tools necessary to make informed and successful career trajectory decisions and deliver additional mentoring and oversight on each trainee to enable them to graduate within the average time period for graduate students at UCLA. Eighth, CBI will provide an inclusive, supportive and diverse environment with approximately equal numbers of chemically and biologically oriented students, equal numbers of males and females, and 30% persons from underrepresented groups, as well as individuals with disabilities that have a strong identity as the UCLA CBI both as trainees and as alumni. To reach these aims a rigorous program of classes, training, and mentoring, coupled with recruitment and retention of persons from all groups and physical and learning abilities and a building of a strong UCLA CBI identity are proposed. An excellent team of world class faculty scholars is assembled who are also focused and serious about training and mentoring. UCLA provides extensive support and a large and diverse pool of excellent students to draw from to successfully reach these goals.

项目摘要 UCLA CBI培训计划的总体目标是教育一群多样的科学家，他们将在数十年中，在化学与生物学之间的界面上，在道德上领导严格的研究和培训来。具体而言，有人提出，生物学业余爱好者的出色化学家将接受培训以识别并严格解决生物学中最重要的问题，并与生物学家高度合作。同样，建议使用化学技术作为黑匣子的生物学家将其转换为可以确定新的化学方法来解决其生物学问题并感到舒适的专家与化学家合作。 UCLA CBI计划通过分解隔离部门，将学员沉浸于最先进的跨学科研究，这些研究跨越了界面化学和生物学。提出了以下具体目的：首先，CBI将培训研究生化学与生物学界面的研究语言和技术。具体而言，化学家将学习为了批判性评估论文，熟悉技术并能够严格讨论研究生物学主题，反之亦然。其次，CBI将教学学生的背景，以了解化学生物学界面的基本原理和尖端研究，使其能够提炼信息以将其独立应用于自己的研究并发展新想法。第三，CBI会使学生能够磨练自己的口语技能并有效地在团队中工作，尤其是在生物学领域的人对于化学家而言，反之亦然。第四，将指示学生有关道德和负责任的行为研究以使他们遵循自己的研究中的道德原则，并将这些标准掌握给他人。第五，CBI学员将接受有关严格和可重复性的基本面的教育，以便将其应用于他们自己的研究并在他人的工作中启用这些因素的识别和解释。第六和第七，CBI将使学生能够专业发展自己的全部潜力，从而为他们提供所有做出明智和成功的职业轨迹决策并提供额外指导所需的工具并监督每个学员，使他们能够在研究生平均时间内毕业在加州大学洛杉矶分校。第八，CBI将提供一个包容性，支持和多样化的环境，大致相等化学和生物学的学生人数，男性和女性的数量相等，30％来自代表性不足的群体的人，以及具有强烈认同的残疾人 UCLA CBI都是学员和校友。达到这些目标是一项严格的课程，培训和指导，再加上各个群体以及身体和学习能力的人的招聘和保留并提出了强大的UCLA CBI身份的建筑物。一支世界一流学者的优秀团队是集会的人也专注于培训和指导。 UCLA提供广泛的支持还有一大批优秀的学生可以从成功实现这些目标。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure.

DOI：
10.1021/jacs.3c10179
发表时间：
2023-11-22
期刊：
Journal of the American Chemical Society
影响因子：
15
作者：
Yan C;Han W;Zhou Q;Niwa K;Tang MJ;Burch JE;Zhang Y;Delgadillo DA;Sun Z;Wu Z;Jacobsen SE;Nelson H;Houk KN;Tang Y
通讯作者：
Tang Y

Biosynthesis and synthetic biology of psychoactive natural products.