Advancing communication strategies to support future HIV vaccine use among African Americans in the South.

推进沟通策略，支持南方非裔美国人未来使用艾滋病毒疫苗。

• 批准号: 10619891
• 负责人: Tiarney D Ritchwood
• 金额: $ 79.55万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-17 至 2023-08-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10619891
• 关键词: Address; African American population; African ancestry; Artificial Intelligence; Attitude; Behavior; Belief; COVID-19; Cognitive Science; Communication; Communities; Computers; Consumption; Data; Focus Groups; Future; Government Agencies; Group Processes; Guidelines; HIV; HIV vaccine; Health; Health Disparities Research; Human; Human immunodeficiency virus test; Image; Imagery; Individual; Influenza vaccination; Infrastructure; Institution; Intention; Intervention; Methodology; Misinformation; Modeling; Morbidity - disease rate; Motivation; Movement; North Carolina; Outcome; Patient Self-Report; Perception; Persons; Persuasive Communication; Phase; Policy Maker; Population; Populations at Risk; Predisposition; Problem Solving; Public Health; Randomized; Recording of previous events; Research Methodology; Research Personnel; Resources; Science; Services; Social Psychology; Source; Speech; Techniques; Technology; Testing; Time; Trust; United States; Universities; Vaccinated; Vaccine Research; Vaccines; Voice; Work; acceptability and feasibility; animation; arm; community based participatory research; community engagement; crowdsourcing; deep learning; design; digital platform; effectiveness evaluation; expectation; experimental study; field study; health communication; improved; innovation; insight; literacy; minority health; minority health disparity; mortality; novel; novel vaccines; pandemic disease; preference; racism; social; social structure; tailored messaging; therapy design; uptake; vaccine acceptance; vaccine access; vaccine development; vaccine evaluation; vaccine hesitancy; vaccine refusal; willingness

Abstract As we enter the fifth decade of the HIV pandemic, innovations in HIV vaccine research and development have moved us closer than ever to the availability of effective vaccines that could end HIV acquisition. Unfortunately, vaccine hesitancy (i.e., delay in acceptance or refusal of vaccination despite availability of vaccination services) poses a major threat to the future uptake of a proven vaccine. Globally, people of African descent have been disproportionately burdened by the HIV pandemic, facing higher morbidity and mortality. In the United States, the convergence of racism, mistrust in the healthcaresystem, inadequate community engagement,and concerns regarding vaccine literacy may exacerbate vaccine hesitancy, reducing future uptake within this population. To prepare for an inevitable HIV vaccine, including those with partial efficacy, we need to field-test targeted messaging campaigns that: are persuasive, counter vaccine-related myths and misinformation, come from trusted sources, and are culturally relevant and impactful. Moreover, campaigns must leverage digital platforms to which greater proportions of the population turn for critical health information. Guided by the Capability Opportunity Motivation—Behavior and Minority Health and Health Disparities Research Frameworks, this study will leverage participatory research methods, artificial intelligence, and infrastructure from ongoing HIV vaccine research at Duke University to: 1) Identify preferences regarding HIV vaccine attributes and communication strategies for African Americans in North Carolina using discrete choice experiments; 2) Develop and pilot crowdsourced and deep learning interventions to assess acceptability, feasibility, and preliminary impact on HIV vaccine literacy, confidence, and willingness; and 3) Evaluate the impact of a crowdsourced vs. a deep learning computer animation intervention on HIV vaccine literacy, confidence, and willingness to vaccinate compared to a control arm using a three-arm randomized experiment. The results of this study will: a) enable us to compare outcomes associated with community-driven, community-engaged, and expert-driven interventions to promote favorable attitudes towards an HIV vaccine; b) identify effective HIV vaccine promotion messages for African Americans; c) inform guidelines informing the rollout and promotion of future novel vaccines.

抽象的 当我们进入Hib大流行的第五个十年时，HIV疫苗研发中的创新已有 不幸的是，我们比以往任何时候都更加接近可能结束艾滋病毒的有效疫苗。 疫苗犹豫（即尽管有疫苗接种服务，尽管尽管有疫苗接种服务，但延迟接受或拒绝空运） 为未来的疫苗摄入构成了一个主要局面。 艾滋病毒大流行的负担不足，在美国面临更高的病态和死亡率。 种族主义的融合，对医疗阶层的不信任，社区参与不足以及担忧 关于疫苗的素养可能会加剧疫苗的犹豫，从而减少了这一人群的未来 为不可避免的艾滋病毒疫苗做准备，包括有颗粒状的疫苗，我们需要针对现场测试 消息传递活动：具有说服力，反疫苗相关的神话和错误信息，来自 可信赖的来源，并且在文化上是相关的和影响力的。 在能力的指导下。 机会动机 - 行为和少数民族健康与健康差异研究框架，本研究 将利用使用HIV疫苗的参与研究方法，人工智能和基础设施 杜克大学的研究：1）确定有关HIV疫苗属性和共同的偏好 北卡罗来纳州非裔美国人的策略使用离散选择实验； 2 众包和深度学习的干预措施评估评估对艾滋病毒的接受，可行性和预后影响 疫苗素养，自信和意愿和3） 与艾滋病毒疫苗素养，信心和接种疫苗接种意愿的计算机动画干预与 使用三臂随机体验的​​控制臂。 与社区驱动，社区参与和专家驱动的干预措施相关的结果，以促进 对HIV疫苗的有利态度； b）确定有效的HIV疫苗促进信息 美国人；