Social support to retain adolescents living with HIV in care and improve ART adherence

社会支持以保留艾滋病毒感染青少年并提高抗逆转录病毒疗法的依从性

• 批准号: 10478844
• 负责人: Tiarney D Ritchwood
• 金额: $ 17.56万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-16 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10478844
• 关键词: AIDS/HIV problem; Adherence; Adolescent; Adult; Africa South of the Sahara; Applications Grants; Appointment; Award; Behavioral; CD4 Lymphocyte Count; Caring; Characteristics; Child; Clinic; Collaborations; Communities; Computers; Country; Data; Development; Disease Management; Emotional; Evaluation; Focus Groups; Food; Frequencies; Future; Goals; Grant; HIV; Health Personnel; Healthcare; Incidence; Individual; Information Networks; Interruption; Intervention; Interview; K-Series Research Career Programs; Knowledge; Link; Malignant Neoplasms; Measures; Mentors; Mentorship; Methods; Monitor; Morbidity - disease rate; Network-based; Outcome; Pathway Analysis; Patient Self-Report; Patients; Persons; Pharmaceutical Preparations; Pilot Projects; Population; Provider; Public Health; Public Health Schools; Records; Regimen; Reporting; Research Personnel; Research Project Grants; Resistance; Resources; Role; Safety; Sampling Studies; Science; Scientist; Secure; Services; Shelter facility; Social Network; Social support; Societies; South Africa; South African; Specificity; Stigmatization; Structure; Target Populations; Testing; Training; United States National Institutes of Health; Universities; Viral; Viral Load result; Virus; Work; acceptability and feasibility; age group; antiretroviral therapy; base; behavioral health; career; career development; design; digital; efficacious intervention; experience; follow-up; global health; improved; improved outcome; innovation; member; mortality; multidisciplinary; pandemic disease; premature; psychologic; scale up; skills; social structure; theories; therapy design; therapy development; transmission process; treatment adherence

ABSTRACT Career Goal: I am committed to a career as a behavioral health scientist, integrating psychological science with public health. My goal is to develop interventions that improve outcomes among adolescents living with HIV (ALWH) globally. Career Development: This career development award will enhance my analytical skills and provide specific training in social network analysis, and intervention development, testing, and evaluation. In this application, I seek to: 1) gain proficiency in the use of social network analysis to inform intervention development; 2) gain essential skills to develop an interactive, network-based, social support intervention to retain ALWH in HIV care and improve ART adherence; 3) obtain the training needed to use preliminary data gathered from this proposal to support a follow up grant proposal for a larger trial aimed at evaluating the proposed intervention. Research Project: Compared to other age groups, South African ALWH are least adherent to medication regimens, resulting in elevated rates of HIV-related morbidity, mortality, medication resistance, and HIV transmission. To improve the outcomes of ALWH, we must identify innovative and engaging methods to retain them in HIV care. The overall goal of the proposed study is to advance knowledge on the role of ALWHs’ social networks in their treatment-related outcomes and develop a network-based, social support intervention to retain them in HIV care and increase ART adherence. First, I will conduct an egocentric social network analysis of ALWH to determine how key members of their social networks influence their retention in HIV care and ART adherence. Next, I will conduct qualitative analysis using data from ALWH and their network members to identify best practices to facilitate intervention acceptability and feasibility. Then, I will use participatory methods to adapt two network-based interventions to fit the target population and increase their retention in HIV care and ART adherence. Lastly, I will conduct a pilot study in Cape Town, South Africa to evaluate the intervention. Mentorship: I will work with a highly accomplished, multidisciplinary team of experts who will support me over the course of the proposed project. My mentors are Drs. John Bartlett (Duke University), Michael Sweat (MUSC Center for Global Health), Linda-Gail Bekker (Desmond Tutu HIV Centre, University of Cape Town), Michael Relf (Duke University), and Carl Latkin (Johns Hopkins Bloomberg School of Public Health) and my advisors are Drs. Audrey Pettifor (UNC) and Joseph Tucker (UNC). Future Directions. This award will also inform future NIH grant applications (R34 and R01) to optimize and evaluate the intervention in a larger study sample.

抽象的 职业目标：作为行为健康科学家，我从事职业生涯，整合心理学科学 我的目标是结束。 全球艾滋病毒（ALWH）。 并提供社交网络分析以及国际发展，测试和评估的特定培训。 在此应用程序中，我寻求：1）在使用社交网络分析来干预方面获得利润 发展； 2）获得基于网络的社会支持的基本技能 保留ALWH在HIV护理中并改善艺术依从性； 3） 从提案中收集到支持后续赠款提案 支撑性的研究项目：与其他年龄段相比 遵守药物治疗方案，导致艾滋病毒相关的病态率升高，死亡率，药物 阻力和艾滋病毒的传播。 将它们保留在Hib护理中的吸引力。 关于ALWH的社交网络在与治疗相关的结果中的作用，并开发基于网络的， 社会支持干预措施将其保留在Hib护理中并提高艺术的粘附。 以ALWH的为中心的社交网络分析，以确定其社交网络的关键成员如何影响 他们在艾滋病毒护理和艺术依从性方面的保留。 然后，网络成员确定最佳实践，以促进干预性和可行性。 我将使用参与方法调整两种基于网络的干预措施，以适合目标人群和 提高他们在艾滋病毒护理和艺术依从性方面的保留。 南非评估干预措施。 专家团队将在我的导师中支持我 巴特利特（杜克大学），迈克尔·斯茨（MUSC全球健康中心），琳达·盖尔·贝克（Linda-Gail Bekker）（Desmond Tutu） 艾滋病毒中心，开普敦大学），迈克尔·罗夫（杜克大学）和卡尔·拉特金（Johns Hopkins） 彭博公共卫生学院和我的顾问是Audrey Pettifor（UNC）和Joseph Tucker （UNC）。 并评估较大的研究样本中的干预措施。