Understanding the effects of listening effort on sentence processing and memory in sensorineural hearing loss: Evidence from simultaneous electrophysiology and pupillometry

了解听力努力对感音神经性听力损失的句子处理和记忆的影响：来自同步电生理学和瞳孔测量的证据

• 批准号: 10914386
• 负责人: Brennan Payne
• 金额: $ 2.21万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10914386
• 关键词: Acoustics; Address; Adopted; Adult; Affect; Age; Aging; Area; Attention; Audiology; Award; Brain; Chronic; Clinical; Clinical assessments; Cognitive; Comprehension; Data; Dementia; Development; Elderly; Electrophysiology (science); Event; Evidence based intervention; Extramural Activities; Foundations; Funding; Future; Goals; Health; Impairment; Intervention; Knowledge; Language; Literature; Measures; Memory; Methods; Mydriasis; National Institute on Deafness and Other Communication Disorders; Neurocognitive; Noise; Performance; Phonetics; Physiological; Prevalence; Process; Psycholinguistics; Public Health; Quality of life; Research; Research Priority; Resources; Retrieval; Risk; Semantics; Sensorineural Hearing Loss; Social isolation; Speech; Speech Perception; Testing; Time; Voice; Work; age related; career; clear speech; clinically relevant; cognitive neuroscience; cost; design; evidence base; experience; experimental study; hearing impairment; improved; innovation; insight; language processing; memory process; neural; neuromechanism; novel; response; specific language impairment; speech in noise; speech processing; syntax

PROJECT SUMMARY / ABSTRACT Sensorineural hearing loss (SNHL) is among the most prevalent chronic conditions in aging and has a profoundly negative effect on speech comprehension, leading to increased social isolation, reduced quality of life, and increased risk for the development of dementia in older adulthood. Typical audiological tests and interventions, which focus on measuring and restoring audibility, do not explain the full range of cognitive difficulties that adults with hearing loss experience in speech comprehension. For example, adults with SNHL have to work disproportionally harder to decode acoustically degraded speech. That additional effort is thought to diminish shared executive and attentional resources for higher-level language processes, impacting subsequent comprehension and memory, even when speech is completely intelligible. This phenomenon has been referred to as listening effort (LE). There is a growing understanding that these cognitive factors are a critical and often “hidden effect” of hearing loss. At the same time, the effects of LE on the neural mechanisms of language processing and memory in SNHL are currently not well understood. In order to develop evidence- based assessments and interventions to improve comprehension and memory in SNHL, it is critical that we elucidate the cognitive and neural mechanisms of LE and its consequences for speech comprehension. In this project, we adopt a multi-method approach, combining methods from clinical audiology, psycholinguistics, and cognitive neuroscience to address this gap of knowledge. Specifically, we adopt a novel and innovative method of co-registering pupillometry (a reliable physiological measure of LE) and language-related event-related brain potential (ERP) measures during real-time speech processing to characterize the effects of acoustic challenge and LE on high-level language processes (e.g., semantic retrieval, syntactic integration) and subsequent speech memory in older adults with SNHL. This innovative work addresses a time-sensitive gap in the literature regarding the identification of objective and reliable markers of specific neurocognitive processes impacted by acoustic challenge and LE in age-related SNHL.

项目摘要 /摘要 感官听力损失（SNHL）是衰老中最普遍的慢性疾病之一，具有 对语音理解的深刻负面影响，导致社会隔离的增加，质量降低 生活，增加了成年痴呆症的风险。典型的听力学测试和 侧重于衡量和恢复可听性的干预措施不能解释全部认知范围 在语音理解中具有听力损失经验的成年人的困难。例如，成年人患有SNHL 必须更难地进行精确解码的语音降解。考虑了额外的努力 减少共享的高管和注意力资源的高级语言流程，从而影响 随后的完成和记忆，即使语音完全可以理解。这种现象有 被称为听力工作（LE）。越来越了解这些认知因素是 听力损失的关键且通常是“隐藏的效果”。同时，LE对神经机制的影响 目前对SNHL中语言处理和记忆的了解尚不广泛理解。为了发展证据 - 基于改善SNHL的理解和记忆的基于评估和干预措施，我们至关重要 阐明LE的认知和神经机制及其对语音理解的后果。在这个 项目，我们采用了一种多方法方法，结合了临床听力学，心理语言学和 认知神经科学解决这一知识差距。具体来说，我们采用了一种新颖而创新的方法 共同注册的化学计量法（对LE的可靠物理测量）和与语言有关的事件相关的大脑 实时语音处理期间的潜力（ERP）措施以表征声学挑战的影响 和LE在高级语言过程（例如语义检索，句法集成）和随后的 SNHL老年人的语音记忆。这项创新的工作解决了时间敏感的差距 有关特定神经认知过程的客观和可靠标记的文献 在与年龄有关的SNHL中受到声学挑战和LE的影响。