Miami Center for AIDS Research

迈阿密艾滋病研究中心

• 批准号: 10907277
• 负责人: Savita Pahwa
• 金额: $ 46.74万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-11-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10907277
• 关键词: AIDS related cancer; Academy; Achievement; Acquired Immunodeficiency Syndrome; Administrative Supplement; Advisory Committees; Affect; African American population; Aging; Area; Award; Cancer Center; Career Mobility; Child; Clinical; Clinical Sciences; Cohort Studies; Collaborations; Communicable Diseases; Communities; Community Outreach; County; Dedications; Development; Doctor of Philosophy; Education; Elements; Emerging Communicable Diseases; Epidemic; Event; Faculty; Faculty Recruitment; Federally Qualified Health Center; Florida; Fostering; Funding; Geography; Goals; Grant; Growth; HIV; HIV diagnosis; HIV/AIDS; Health; Hospitals; Immune response; Immunotherapy; Individual; Industry; Infection; Inflammation; Infrastructure; Injecting drug user; Institution; Interest Group; International; Knowledge; Laboratories; Latino; Latinx; Leadership; Lesbian Gay Bisexual Transgender Queer; Life; Link; Malignant Neoplasms; Mental Health; Mentors; Mentorship; Metabolism; Minority; Mission; National Institute of Mental Health; Needle-Exchange Programs; Needs Assessment; Neurosciences; Persons; Play; Policies; Positioning Attribute; Research; Research Personnel; Resource Allocation; Resources; Role; Science; Shapes; Strategic Planning; The Multicenter AIDS Cohort Study; Translational Research; Treatment outcome; United States National Institutes of Health; Universities; Woman; Women' s Interagency HIV Study; acronyms; base; behavioral and social science; biobehavior; career development; community engagement; experience; health equity; improved; innovation; medical schools; men who have sex with men; next generation; novel; perinatal HIV; pre-exposure prophylaxis; prevent; programs; recruit; reproductive outcome; success; synergism; tool; transmission process; working group

Project Summary/Abstract (Overall) The Miami Center for AIDS Research (CFAR) at the University of Miami (UM) Miller School of Medicine (MSOM) is the only CFAR in Florida, the state with the highest rate of new infections with Miami as its epicenter, underscoring the need for a CFAR. In the past 5 years, the Miami CFAR has catalyzed innovative research in health equity and ending the HIV epidemic (EHE), HIV in women, AIDS related malignancies, HIV cure, and immune responses and has increased the Funded Research Base. It has developed a new Mentoring Academy program to launch junior investigators into leadership positions and added 14 new faculty. It has supported nearly $3 million in pilot awards between CFAR (1.45 million) and State ($1.6 million), and received >$1.6 million in NIH Administrative Supplements. During the proposed 4th cycle of funding, notable new successes at UM have propelled the CFAR’s ability to leverage new resources. These achievements include the Center for HIV and Research in Mental Health (CHARM), awarded by NIMH in 2019, Sylvester Cancer Center (SCC), that received NCI Cancer Center designation also in 2019; and the Clinical and Translational Science Institute (CTSI) that was renewed in 2018. The Miami CFAR’s five Cores, Administrative, Developmental, Clinical Sciences, Laboratory Sciences, Bio-Behavioral and Community Engagement, and the HIV & Aging Scientific Working Group (SWG) collaborate on the following 5 specific aims of the CFAR to promote the CFAR mission. Aim 1: Provide scientific leadership dedicated to support HIV/AIDS research to define scientific priorities, in alignment with the NIH, institutional and geographic needs; Aim 2: Leverage Institutional resources and enhance relationships with the afore-mentioned new Centers and HEIDI (HIV/AIDS and Emerging Infectious Diseases Institute), supported by the State, and UM Departments; Aim 3: Catalyze the synergies between Miami CFAR Cores, SWG, Scientific Interest Groups (SIGs) to collaborate with national research networks, industry, other FL institutions, and other CFARs; Aim 4: Grow the next generation of leaders in HIV/AIDS research through mentoring, career development and funding support; Aim 5: Nurture the partnership with the Florida Department of Health for research implementation, increase the reach of the CFAR towards EHE, and promote community outreach events to build on Miami CFAR’s efforts for community engagement. Under the leadership of Savita Pahwa, MD, Director and Mario Stevenson, PhD, Co-Director, the Miami CFAR has established an enviable position at the MSOM with HIV/AIDS research being designated as one of four strategic pillars that have been prioritized for resource allocation and faculty recruitment. The Internal and External Advisory Committees, and strategic planning provide opportunities for appraisal to improve the CFAR. With its strong infrastructure, capable faculty, strong collaborative interactions within and outside of UM, and opportunities for leveraging UM and State resources, we are confident that the next cycle of the Miami CFAR will be successful in achieving its goals.

项目摘要/摘要（总体） 迈阿密大学 (UM) 米勒医学院 (MSOM) 迈阿密艾滋病研究中心 (CFAR) 是佛罗里达州唯一的CFAR，该州以迈阿密为震中，新增感染率最高， 强调了 CFAR 的必要性 在过去 5 年中，迈阿密 CFAR 促进了以下方面的创新研究。 健康和公平结束艾滋病毒流行（EHE）、妇女艾滋病毒、艾滋病相关恶性肿瘤、艾滋病毒治愈和 免疫反应并增加了资助的研究基地，它建立了一个新的指导学院。 计划将初级研究员推上领导岗位，并增加了 14 名新教师，该计划已支持近 10 名新教师。 CFAR（145 万美元）和州政府（160 万美元）之间提供 300 万美元的试点奖励，NIH 获得超过 160 万美元 在拟议的第四个资助周期中，密歇根大学取得了显着的新成就。 推动了 CFAR 利用新资源的能力，这些成就包括艾滋病毒中心和 心理健康研究 (CHARM)，2019 年由 NIMH 授予，西尔维斯特癌症中心 (SCC)，获得 2019 年还被指定为 NCI 癌症中心；以及临床和转化科学研究所 (CTSI) 2018 年更新。迈阿密 CFAR 的五个核心：行政、发展、临床科学、实验室 科学、生物行为和社区参与以及艾滋病毒和老龄化科学工作组 (SWG) 就 CFAR 的以下 5 个具体目标进行合作，以促进 CFAR 的使命 目标 1：提供科学。 领导层致力于支持艾滋病毒/艾滋病研究，以确定科学优先事项，与 NIH 保持一致， 机构和地理需求；目标 2：利用机构资源并加强与 上述新中心和 HEIDI（艾滋病毒/艾滋病和新发传染病研究所），由 州政府和密歇根大学部门；目标 3：促进迈阿密 CFAR 核心、SWG、科学部门之间的协同作用 兴趣小组 (SIG) 与国家研究网络、行业、其他 FL 机构和其他机构合作 CFAR；目标 4：通过指导、职业培养下一代艾滋病毒/艾滋病研究领导者 发展和资金支持；目标 5：培育与佛罗里达州卫生部的合作伙伴关系 研究实施，扩大 CFAR 对 EHE 的影响，并促进社区外展 在医学博士萨维塔·帕瓦 (Savita Pahwa) 的领导下，迈阿密 CFAR 开展了一系列活动，以促进社区参与。 迈阿密 CFAR 主任兼联合主任马里奥·史蒂文森 (Mario Stevenson) 博士在业界建立了令人羡慕的地位 MSOM 的艾滋病毒/艾滋病研究被指定为优先考虑的四大战略支柱之一 资源分配和教师招聘。内部和外部咨询委员会以及战略。 规划提供了评估的机会，以提高CFAR 凭借其强大的基础设施、有能力的师资力量、 密西根大学内部和外部的强有力的协作互动，以及利用密西根大学和州立大学的机会 资源方面，我们有信心迈阿密 CFAR 的下一周期将成功实现其目标。

项目成果

UNG protects B cells from AID-induced telomere loss.

• DOI: 10.1084/jem.20160635
• 发表时间: 2016-10-17
• 期刊: The Journal of experimental medicine
• 作者: Cortizas EM;Zahn A;Safavi S;Reed JA;Vega F;Di Noia JM;Verdun RE
• 通讯作者: Verdun RE

Epstein Barr virus Latent Membrane Protein-1 enhances dendritic cell therapy lymph node migration, activation, and IL-12 secretion.

Epstein Barr 病毒潜膜蛋白-1 增强树突状细胞治疗淋巴结迁移、激活和 IL-12 分泌。

• DOI: 10.1371/journal.pone.0184915
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Termini,JamesM;Gupta,Sachin;Raffa,FrancescaN;Guirado,Elizabeth;Fischl,MargaretA;Niu,Liguo;Kanagavelu,Saravana;Stone,GeoffreyW
• 通讯作者: Stone,GeoffreyW

Microbial Translocation and Immune Activation in HIV-1 Infected Pregnant Women.

HIV-1 感染孕妇的微生物易位和免疫激活。

• DOI: 10.2174/1570162x16666180731145011
• 发表时间: 2018
• 期刊: Current HIV research
• 影响因子: 1
• 作者: Mitchell,CharlesD;Dominguez,Sady;Roach,Margaret;George,Varghese;Rinaldi,Stefano;Fischl,Margaret;Potter,Jonell;Tyson,Brittany;Pahwa,Savita
• 通讯作者: Pahwa,Savita

Defective dendritic cell response to Toll-like receptor 7/8 agonists in perinatally HIV-infected children.

围产期 HIV 感染儿童中树突状细胞对 Toll 样受体 7/8 激动剂的反应有缺陷。

• DOI: 10.1111/2049-632x.12067
• 发表时间: 2013
• 期刊: Pathogens and disease
• 影响因子: 3.3
• 作者: Selvaraj,Anbalagan;Pilakka-Kanthikeel,Sudheesh;Bhavani,PerumalKannabiran;Hanna,LukeE;Pahwa,Savita;Swaminathan,Soumya
• 通讯作者: Swaminathan,Soumya

Influence of immune activation on the risk of allograft rejection in human immunodeficiency virus-infected kidney transplant recipients.

免疫激活对人类免疫缺陷病毒感染的肾移植受者同种异体移植排斥风险的影响。

• DOI: 10.1016/j.trim.2016.06.001
• 发表时间: 2016
• 期刊: Transplant immunology
• 影响因子: 1.5
• 作者: Lorio,MarcoA;Rosa,Rossana;Suarez,JoseF;Ruiz,Phillip;Ciancio,Gaetano;Burke,GeorgeW;Camargo,JoseF
• 通讯作者: Camargo,JoseF