Administrative Core

行政核心

• 批准号: 10900830
• 负责人: E.Shelley Hwang
• 金额: $ 13.37万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-04 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10900830
• 关键词: 3-Dimensional; Accounting; Atlases; Behavior; Breast; Classification; Collaborations; Communication; Complement; Comprehensive Cancer Center; Data; Data Analyses; Ensure; Ethics; Evaluation; Expenditure; Extramural Activities; FAIR principles; Feedback; Funding; Human; Human Resources; Infrastructure; Institution; Leadership; Life; Longitudinal cohort; Malignant Neoplasms; Manuscripts; Modeling; Molecular; Monitor; Natural History; Noninfiltrating Intraductal Carcinoma; Office of Administrative Management; Parents; Patients; Policies; Preparation; Quality Control; Reporting; Reproducibility; Research; Research Personnel; Resource Development; Resources; Retrospective cohort; Teleconferences; Testing; Tissues; United States National Institutes of Health; Work; computerized data processing; conflict resolution; data integrity; data sharing; expectation; innovation; meetings; member; multimodality; novel; operation; premalignant; programs; skills; success; synergism; tumor

ABSTRACT – Administrative Core The Administrative Core will support the general objectives of the Breast Pre-Cancer Atlas, which are to 1) develop a findable, accessible, interoperable, and reusable platform for organizing and sharing three- dimensional, multi-modal breast pre-cancer data derived that facilitates the discovery of both the natural history of the pre-cancer and predictors of progression to life-threatening cancers, and 2) populate that platform with data from both retrospective and longitudinal cohorts of patients with DCIS and demonstrate its use to construct an atlas to test novel predictors of progression. To do this, the Administrative Core will facilitate administrative management of the Breast Pre-Cancer Atlas, cultivate collaboration and communication within the Atlas as well as with other HTAN Pre-Cancer Centers, ensure fiscal and regulatory compliance, and provide consistent evaluation and monitoring to ensure effective progress of the program. The Specific Aims of this Core will be: 1) To provide organizational, administrative, and scientific leadership by having mPIs with complementing skill sets to provide credible examples of research success, demonstrate respect and concern for all team members, build team identity, culture, and coherence, cultivate expectations of innovation and excellence, leverage institutional as well as extramural resources, provide constructive feedback and conflict resolution, and model ethical behavior; 2) To provide administrative management by overseeing distribution of funds to and accounting for all expenditures in the Center, including Research Units, and provide clerical support. It will also coordinate with other PCA and HTA Research Centers to implement compliance with NIH policies, oversee quality control and product release, and ensure fiscal and regulatory compliance; 3) To promote integration within the Breast Pre- Cancer Atlas Center and across the Institutional PCA and HTA Research Centers by leveraging institutional support and working closely with the infrastructure of the affiliated NCI-designated Comprehensive Cancer Centers to ensure that resources and infrastructure are optimally utilized, economies of scale are realized, and overlaps eliminated. The Administrative Core also will help to plan and coordinate HTAN meetings and teleconferences; 4) To develop capabilities and oversee data operations by confirming data sharing and defining and developing best practices for data operations in collaboration with the Data Analysis Unit to ensure that reliable and valid data are generated, managed, and analyzed in a way that ensures data integrity and reproducibility of research findings; 5) To evaluate and report research progress and to ensure bidirectional exchange of research findings between the Breast Pre-Cancer Atlas Center and other PCA and HTAN Centers.

摘要 - 行政核心 行政核心将支持乳房前癌地图集的一般目标，该目标是1） 开发一个可发现的，可访问，可互操作和可重复使用的平台，用于组织和共享三个 得出的尺寸，多模式的乳房前癌前数据促进了两种自然历史的发现 前癌症和进步癌症的预测因素，以及2）填充该平台 来自DCIS患者的回顾性和纵向人群的数据，并证明其用于构建 测试新进展预测指标的地图集。为此，行政核心将有助于行政 管理乳房前癌地图集，也在地图集中培养协作和交流 与其他HTAN前癌中心一样，确保财政和监管合规性，并提供一致的 评估和监视以确保计划的有效进展。该核心的具体目的是：1） 通过完成完成技能的MPI来提供组织，行政和科学领导 为了提供可靠的研究成功实例，表现出所有团队成员的尊重和关注，建立 团队身份，文化和连贯性，培养对创新和卓越的期望，利用机构 以及壁外资源，提供建设性的反馈和解决冲突，并建模道德 行为; 2）通过监督所有资金分配并为所有人进行核算，以提供行政管理 中心的支出，包括研究单位，并提供文书支持。它也将与 其他PCA和HTA研究中心，以实施符合NIH政策，海外质量控制和 产品释放，并​​确保财政和法规合规性； 3）促进乳房中的整合 癌症地图集中心以及整个机构PCA和HTA研究中心通过利用机构 支持并与非关联NCI指定综合癌症的基础设施紧密合作 中心确保资源和基础设施最佳利用，实现规模经济，并且 取消了重叠。行政核心还将帮助计划和协调HTAN会议，并 电信； 4）通过确认数据共享和定义来开发功能并监督数据操作 并与数据分析单元合作开发用于数据操作的最佳实践，以确保 可靠且有效的数据以确保数据完整性和的方式生成，管理和分析 研究结果的可重复性； 5）评估和报告研究进度并确保双向 乳房前地图集中心与其他PCA和HTAN中心之间的研究结果交换。