Nutrition for Precision Health, powered by the All of Us Research Program: Research Coordinating Center

精准健康营养，由“我们所有人研究计划”提供支持：研究协调中心

• 批准号: 10757488
• 负责人: MARIE G GANTZ
• 金额: $ 319.97万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10757488
• 关键词: Address; All of Us Research Program; Artificial Intelligence; Bioinformatics; Biometry; Clinical; Clinical Trials; Collaborations; Communication; Consensus; Data; Data Collection; Diet; Dietary Assessment; Dietary Intervention; Dietary Practices; Domiciles; Ensure; FAIR principles; Food Patterns; Goals; Health; Information Systems; Infrastructure; Institution; Institutional Review Boards; International; Intervention; Intervention Trial; Leadership; Medical; Mission; Monitor; Nature; Nutrition Assessment; Phase; Population; Precision Health; Principal Investigator; Process; Protocols documentation; Recording of previous events; Research; Research Personnel; Safety; Site; Specimen; System; Time; Universities; data curation; data management; data standards; design; dietary; empowerment; experience; feeding; implementation facilitation; improved; individual response; innovation; multidisciplinary; nutrition; precision nutrition; prediction algorithm; tool; wearable device

Contact PD/PI: GANTZ, Marie G. PROJECT SUMMARY/ABSTRACT From Proposal: The overarching goal of the RTI International–Cornell Research Coordinating Center (RCC) is to provide seamless operational support and multidisciplinary experience for building consensus in the Nutrition for Precision Health Consortium (NPHC). In the 1-year planning phase, we will prioritize efficiency and objectivity in facilitating the design of diet modules (1: usual dietary assessment; 2: controlled feeding dietary intervention; and 3: domiciled dietary intervention) nested in All of Us and their research protocols. In the 4-year implementation phase, we will facilitate the implementation of Modules 1–3, enable the flow of quality data and specimens across the NPHC, and integrate curated, Artificial intelligence (AI)–ready data into the All of Us Researcher Workbench, using our established data coordination processes and systems. Innovations in our approach include tools for conducting dietary studies in hard-to-reach populations, idiographic (or subject-as-own-control) clinical trials, and wearables research tools and analytics. Specifically, the proposed RCC will excel in administrating and coordinating NPHC and its research initiatives, clinical interventions, and data and biospecimen sharing, as follows: Aim 1: Optimize the scientific rigor of Modules 1–3 Aim 2: Ensure NPHC study data are FAIR (Findable, Accessible, Interoperable, and Reusable) Aim 3: Enable seamless data collection, curation, and transfer including to the Researcher Workbench Aim 4: Minimize time to launch of Modules 1–3 Aim 5: Maximize the efficiency of consortium communications and collaborations NPHC is being launched to address major research gaps in nutrition; the nature of these gaps and the complexity of the NPHC activities cannot be underscored enough. RCC will be led by Multiple Principal Investigators with complementary expertise in coordinating center and multisite leadership and biostatistics (Dr. Gantz at RTI) and nutritional intervention and clinical expertise (Dr. Mehta at Cornell University) with the support of a strong and diverse team, organized around cores for Design and Analytics, Data Curation and Systems, and Study Implementation. Other key components include single IRB and medical safety monitoring. The RCC will also benefit from our collective institutional strengths, with an expert pool of wide- ranging research and clinical backgrounds pertinent to the NPHC (e.g., omics, bioinformatics, AI, clinical trial intervention, nutritional assessment). The proposed RCC is immediately and amply prepared to support to NPHC in its mission to develop clinically meaningful algorithms that predict individual responses to food and dietary patterns and to improve health across diverse U.S. populations. Project Abstract

联系PD/PI：Gantz，Marie G. 项目摘要/摘要 来自提案： RTI国际与康奈尔研究协调中心（RCC）的总体目标是 为建立共识提供无缝的运营支持和多学科经验 在Precision Health Consortium（NPHC）的营养中。在1年计划阶段，我们将 优先考虑效率和目标，以促进饮食模块的设计（1：通常的饮食 评估; 2：受控的饮食干预；和3：区域性的饮食干预） 嵌套在我们所有人及其研究方案中。在4年实施阶段，我们将 促进模块1-3的实施，实现质量数据和标本的流动 跨NPHC，并集成了策划的人工智能（AI） - 准备数据到我们所有人 研究人员工作台，使用我们既定的数据协调过程和系统。 我们方法中的创新包括用于难以触及的饮食研究的工具 人群，二世（或主题对照）临床试验和可穿戴设备研究工具 和分析。特别是，拟议的RCC将在管理和协调方面表现出色 NPHC及其研究计划，临床干预以及数据和生物测量共享， 以下内容： 目标1：优化模块的科学严谨1-3 目标2：确保NPHC研究数据公平（可访问，可互操作，可互操作，并且 可重复使用的） AIM 3：启用无缝数据收集，策展和转移，包括研究人员 工作台 目的4：最小化模块发射的时间1-3 目标5：最大化财团通信和合作的效率 NPHC正在启动以解决营养的主要研究差距；这些差距的本质 NPHC活动的复杂性不能得到足够的强调。 RCC将由 多个主要研究人员，具有完善的协调中心专业知识和 多站点领导力和生物统计学（RTI的Gantz博士）以及营养干预和临床 专业知识（康奈尔大学的Mehta博士）在一个强大而多样的团队的支持下， 围绕核心进行设计和分析，数据策展和系统，并研究 执行。其他关键组件包括单个IRB和医疗安全监控。这 RCC还将从我们的集体机构优势中受益，并拥有广泛的专家 与NPHC相关的研究和临床背景（例如，OMICS，生物信息学， AI，临床试验干预，营养评估）。拟议的RCC立即 充分准备支持NPHC的使命，以开发临床上有意义的算法 这可以预测个人对食物和饮食模式的反应，并改善整个健康的健康 美国多样化的人口。 项目摘要