Effects of parental history of suicidal behavior on middle/late childhood: Longitudinal assessment of early markers of suicide risk

父母自杀行为史对童年中后期的影响：自杀风险早期标记的纵向评估

• 批准号: 10750571
• 负责人: Arielle Hope Sheftall
• 金额: $ 42.69万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10750571
• 关键词: Adolescence; Adolescent; Age; Age of Onset; Arousal; Arousal and Regulatory Systems; Attention; Behavioral; Biological; Black race; Cause of Death; Child; Childhood; Development; Emergency department visit; Emotional; Enrollment; Family; Feeling suicidal; Female; Functional disorder; Future; Goals; Intervention; Interview; Knowledge; Learning; Measures; Mediating; Mediator; Mental Health; Methods; National Institute of Mental Health; Neurocognitive; Neurocognitive Deficit; Parents; Participant; Patient Self-Report; Population Heterogeneity; Populations at Risk; Positive Valence; Prevention; Prevention strategy; Primary Prevention; Public Health; Race; Recording of previous events; Regulation; Research; Research Domain Criteria; Research Priority; Rewards; Risk; Risk Factors; Role; Sampling; Social Processes; Strategic Planning; Suicide; Suicide attempt; System; Techniques; Testing; Visit; Youth; age group; age related; aged; black men; black women; cognitive control; cognitive system; cohort; computerized; early onset; emotion dysregulation; experience; externalizing behavior; high risk; high risk population; male; non-suicidal self injury; offspring; peer; prevent; racial disparity; racial population; recruit; sex; sex disparity; social communication; suicidal adolescent; suicidal behavior; suicidal risk; suicide rate; transmission process; trend

PROJECT SUMMARY/ABSTRACT Suicide is the fifth leading cause of death among U.S. children 5 to 12 years, yet limited research on childhood suicide and suicidal behavior (SB) exists. The National Institute of Mental Health (NIMH) has acknowledged this critical gap as a high research priority. A significant risk factor for the early onset of a first suicide attempt (SA) is a parental history of SB. Although the familial transmission of SB is well documented, research examining the specific mechanisms associated with familial risk is limited. Our ongoing NIMH-R21 study (Cohort 1) is investigating factors related to the familial risk of SB in children, 6-9 years, with (PH+; n=100) and without (PH-; n=100) a parental history of SA. This proposed R01 study will continue annual follow-ups for Cohort 1 and add an additional 300 newly enrolled families (Cohort 2; ages 9-11 years; 150 per PH group) for a total sample of 500 parent-child dyads. Youth will be followed for four years from mid/late-childhood through early/mid-adolescence. Using the Research Domain Criteria (RDoC) framework, we will examine the trajectories of neurocognitive function (NF), emotional reactivity/regulation (ERR), non-suicidal self-injury (NSSI), suicidal ideation (SI), and SA in PH+ and PH- youth along with contributions by sex and race. Study participants at first assessment include youth 7-12 years. At last assessment, youth ages will range from 10-15 years. Both groups, PH+ and PH-, will be balanced by sex and race. Two main research aims and one exploratory aim will be tested. Aim 1: Examine longitudinally how PH status is associated with trajectories of NF and ERR constructs measured during mid/late-childhood through early/mid-adolescence. Aim 2: Investigate the potential mediating role of NF and ERR constructs on the association between PH status and offspring NSSI, SI, and SA. Exploratory Aim: Test sex and race as potential moderators of ERR and NF trajectories, and on the association between PH status and offspring NSSI, SI, and SA. This proposal’s central hypotheses are that (1) PH+ status increases vulnerability for developmental trajectories characterized by NF deficits and emotional dysfunction/dysregulation; (2) these trajectories will mediate the association between PH status and youth NSSI, SI, and SA; and (3) these associations between trajectories and SB/NSSI will be moderated by both sex and race. The hypotheses are informed by preliminary findings from the ongoing NIMH- R21 study, where group differences were found for ERR, SB, and NF. The proposed R01 study aligns well with the NIMH 2020 Strategic Plan for Research with emphasis on Goal 2-investigating mental health trajectories and inclusion of diverse samples. Completing the proposed study will assist with the identification of specific mechanisms associated with the familial risk of SB, determine if sex and race moderate the associations between risks and youth SB, and provide direction for targeted prevention strategies for high-risk youth.

项目摘要/摘要 自杀是5至12岁的美国儿童中第五大死亡原因，但对童年的研究有限 存在自杀和自杀行为（SB）。国家心理健康研究所（NIMH）已承认 这一关键差距是很高的研究重点。早期首次自杀尝试的重要危险因素 （SA）是SB的父母历史。尽管SB的家庭传播已得到充分记录，但研究 检查与家庭风险相关的具体机制是有限的。我们正在进行的NIMH-R21研究 （队列1）正在调查与儿童的SB家庭风险有关的因素，6-9岁，（pH+; n = 100）和 没有（ph-; n = 100）SA的父母历史。这项拟议的R01研究将继续为 队列1，并增加300个新入学的家庭（队列2； 9-11岁；每组150年） 总样本为500个亲子二元。从中/晚期开始，将遵循青年四年 早期/青春期。使用研究领域标准（RDOC）框架，我们将检查 神经认知功能（NF）的轨迹，情绪反应/调节（ERR），非杀伤性自我伤害 （NSSI），自杀想法（SI）和SA在pH+和PH-青年中以及性别和种族的贡献。学习 初次评估的参与者包括青年7-12岁。最后评估，青年年龄范围为10-15 年。 pH+和pH-的两个小组都将通过性别和种族平衡。两个主要研究目的和一个 探索目标将进行测试。目标1：纵向检查pH状态与 NF和ERR构建体在年龄较晚/后期/青春期期间测量。目标2： 研究NF和ERR构建体对pH状态与pH状态之间关联的潜在中介作用 后代NSSI，SI和SA。探索目的：测试性和种族作为ERR和NF的潜在主持人 轨迹，以及pH状态与后代NSSI，SI和SA之间的关联。该提议的中心 假设是（1）pH+状态增加了以NF为特征的发育轨迹的脆弱性 缺陷和情绪功能障碍/功能障碍； （2）这些轨迹将介导PH之间的关联 地位和青年NSSI，SI和SA； （3）轨迹和SB/NSSI之间的这些关联将是 由性和种族主持。这些假设是通过正在进行的NIMH-的初步发现来告知的 R21研究，在其中发现了ERR，SB和NF的组差异。拟议的R01研究与 NIMH 2020年研究战略计划，重点是目标2进行精神健康轨迹 并包括各种样品。完成拟议的研究将有助于确定特定 与SB家庭风险相关的机制，确定性和种族是否适应关联 在风险和青年SB之间，为高风险青年提供了针对性的预防策略的指导。