The contribution of semantic bias to false memory in healthy aging

语义偏差对健康老龄化中错误记忆的贡献

• 批准号: 10749657
• 负责人: Isabelle Lorraine Moore
• 金额: $ 3.78万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-14 至 2025-08-13
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749657
• 关键词: Address; Adult; Age; Aging; Alzheimer' s Disease; Attention; Behavior; Behavioral; Clinical; Cognitive; Cognitive aging; Cues; Data; Dementia; Elderly; Episodic memory; Event; Foundations; Functional Magnetic Resonance Imaging; Goals; Impaired cognition; Knowledge; Link; Longevity; Measures; Memory; Memory impairment; Mission; Perception; Population; Predisposition; Quality of life; Research; Retrieval; Semantic memory; Semantics; Testing; Time; amnestic mild cognitive impairment; cognitive change; episodic memory impairment; experience; experimental study; healthy aging; improved; indexing; insight; neural; neural patterning; neuroimaging; neuromechanism; semantic processing; spatiotemporal; young adult

Project Summary/Abstract Memory concerns are prevalent in healthy cognitive aging and are associated with lower quality of life. False memory – remembering events differently than how they happened – increases across the lifespan. Older adults also show a shift toward semantic memory – memory for concepts – and away from episodic memory – memory for events within a spatiotemporal context. However, it is unclear how the shift toward semantic memory con- tributes to increased false memory in older adults. An improved understanding of the mechanisms that give rise to false memories across the lifespan will be the first step toward alleviating memory concerns in healthy aging. Using a combination of behavioral and neuroimaging approaches, this proposal aims to directly link semantic bias to false memory in older adults. Experimental paradigms traditionally used to investigate false memory capi- talize upon semantic overlap between study items to produce robust false memory effects; however, experiences can also temporally overlap, or occur close together in time. Temporal overlap may differentially impact false memory across the lifespan. Young adults can leverage temporal information to support true memories, and preliminary data suggests that young adults can also utilize temporal information to reject false memories. How- ever, older adults may have greater difficulty utilizing temporal information and thus be more susceptible to falsely remembering. Therefore, identifying the relative contributions of semantic and episodic processing will improve understanding of false memory increases in older adults. This proposal tests the hypothesis that older adults' bias toward semantic processing modulates encoding mechanisms to promote false memory. To determine the extent to which semantic versus episodic processing contribute to false memory, young and older adults will complete a behavioral task in which temporal and semantic overlap between study items is manipulated, and then com- plete a test of false memory. To establish a link between older adults' semantic bias and neural representations of true and false memories, semantic overlap will be manipulated between study items and functional magnetic resonance imaging (fMRI) will be used to measure neural pattern similarity for true and false memories in young and older adults. The proposed research is directly in line with the mission of the NIA, as the results of this pro- posal will provide insight into memory impairments in healthy aging and serve as a first step towards ameliorating memory concerns to improve quality of life in older adulthood. Because healthy aging is characterized by subtle cognitive changes, it can be difficult to distinguish between cognitive declines due to typical aging and those due to amnestic mild cognitive impairments or Alzheimer's Disease. Thus, a more thorough understanding of how the mechanisms that give rise to false memories change in healthy aging will also provide a foundation for further disambiguation of healthy aging from dementia.

项目摘要/摘要 错误的。 记忆 - 以不同的方式记住事件 - 整个老年人都会增加 还显示向语义记忆的转变 - 概念的内存 - 远离情节记忆 - 记忆 但是，对于时空的情况下 致敬老年人的虚假记忆力。 在整个生命周期中，虚假的记忆将是减轻健康衰老中的回忆的第一步。 该建议旨在直接链接语义，结合使用行为和神经影像学方法 传统上用于研究假记忆的实验范式中的虚假记忆 研究项目之间的语义重叠，以产生强大的错误记忆效应； 也可以在时间上重叠，或者及时重叠。 整个救生员的记忆都可以利用时间信息来支持真实的记忆 初步数据表明，年轻人也可以利用时间信息来拒绝虚假记忆。 有史以来，老年人可能会使用时间信息来更加困难，从而更加注意到错误 因此，记住，确定语义和情节处理的相对贡献 了解老年人的错误记忆。 朝着语义处理调节编码机制以促进虚假记忆。 语义与情节处理有助于虚假记忆，年轻人和老年人将完成 一个行为任务，在研究项目之间进行时间和语义重叠的行为任务，而Theen则可以 对错误记忆的测试，以建立老年人的语义偏见和神经的联系 在真实和虚假的记忆中，语义重叠将在研究项目和功能磁性之间 共振成像（fMRI）将用于测量年轻人的真实和记忆的神经体模式相似性 和老年人。 Posal将洞悉健康衰老的记忆障碍，并作为改善的第一步 记忆的关注点以改善旧的成年质量。 认知变化，很难区分典型衰老和应得的认知能力下降 为了敏感的轻度认知障碍或阿尔茨海默氏病。 在健康健康中导致错误记忆变化的机制也将为进一步的基础 对痴呆症健康的歧义。