ShEEP Request for SCANCO microCT

SheEEP 请求 SCANCO microCT

• 批准号: 10738633
• 负责人: Mary Beth Humphrey
• 金额: --
• 依托单位: OKLAHOMA CITY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10738633
• 关键词: 3-Dimensional; Acceleration; Address; Affect; Aging; Animals; Arthritis; Award; Biomedical Research; Bone Regeneration; Bone Tissue; Bone remodeling; Cities; Code; Color; Computer software; Contrast Media; Defect; Degenerative polyarthritis; Dental; Development; Disease; Doctor of Medicine; Doctor of Philosophy; Elasticity; Foundations; Funding; Future; Grant; Health Sciences; Healthcare Systems; Histologic; Image; Immunology; Implant; Institution; Joints; Knee; Laboratories; Maintenance; Malignant Neoplasms; Mechanics; Medical Research; Medical center; Memory; Minor; Neck; Neurosciences Research; Oklahoma; Osteoporosis; Physicians; Pre-Clinical Model; Property; Reproducibility; Research; Research Design; Research Personnel; Resolution; Resources; Sampling; Scanning; Sheep; Specimen; Structure; Surveys; System; Technology; Testing; Time; Tissues; United States National Institutes of Health; Universities; Veterans; Visualization; X-Ray Computed Tomography; bone; experience; imaging system; in vivo; instrument; microCT; new technology; preclinical study; prevent; reconstruction; soft tissue; tool

ABSTRACT We are requesting funds to purchase a Scanco µCT 90 desktop microCT instrument. This instrument enables investigators to conduct high-throughput, high-resolution microCT scanning for a wide range of imaging research applications. By reducing time of scanning and reconstruction as well as automating for up to 32 sample batch scanning, investigators will be able to address important issues such as scientific rigor and reproducibility. Being able to analyze a greater number of samples in a shorter period of time with a higher resolution (2µM vs 10.5µM) will allow bone specimens to more quickly move toward histological tissue analysis and prevent the bottle neck of microCT analysis that currently exists. This technology can be applied to various other imaging needs with the use of contrast agents and will broadly benefit our investigators in the aging and arthritis. An advanced microCT imaging system such as this is not available for research use at the Oklahoma City VA Health Care System or at either of the affiliate institutions, the University of Oklahoma Health Sciences Center or the Oklahoma Medical Research Foundation. Thus, this unique local resource will provide new technology that can be applied to a wide variety of imaging needs, which will broadly benefit VA investigators in the aging, arthritis, cancer, immunology, and neuroscience research fields. Specifically, this instrument will be used by four major users and two minor users who combined have five funded VA Merit grants, as well as a number of future users. The instrument will also benefit two newly established Collaborative Merit Awards and two additional VA Merits focused on preclinical models of osteoarthritis.

抽象的 我们要求资金购买Scanco µCT 90桌面Microct乐器。该乐器可以启用 研究人员进行高通量，高分辨率的微观扫描，以进行广泛的成像研究 申请。通过减少扫描和重建时间以及自动化的时间，最多32个样本批次 扫描，调查人员将能够解决重要的问题，例如科学严谨和可重复性。存在 可以在较短的时间内以更高的分辨率（2µm vs 10.5µm）分析更多样品 将允许骨头标本更快地朝组织学组织分析并防止瓶颈 当前存在的MicroCT分析。这项技术可以应用于其他各种成像需求 使用造影剂，并将广泛地使我们的研究人员在衰老和关节炎方面受益。一个高级 诸如此类的Microct成像系统无法在俄克拉荷马城弗吉尼亚州卫生保健中进行研究 系统或任何一个会员机构，俄克拉荷马大学健康科学中心或 俄克拉荷马州医学研究基金会。那就是，这种独特的本地资源将提供可以提供的新技术 应用于各种成像需求，这将在关节炎，关节炎中广泛受益于VA研究人员 癌症，免疫学和神经科学研究领域。具体而言，该乐器将由四个专业使用 用户和两个组合的次要用户拥有五个资助的VA功绩赠款以及许多未来的用户。 该工具还将受益两个新成立的合作功绩奖和另外两个VA优点 专注于骨关节炎的临床前模型。