State-dependent modulation of interactions of theta and gamma rhythms in working memory

工作记忆中θ节律和伽马节律相互作用的状态依赖性调节

• 批准号: 10740352
• 负责人: Joan A Camprodon
• 金额: $ 45.93万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2025-08-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10740352
• 关键词: Adult; Area; Biological Markers; Brain; Cephalic; Clinical; Clinical Trials; Cognition; Cognitive deficits; Cognitive remediation; Communication; Coupling; Double-Blind Method; Electroencephalography; Electrophysiology (science); Failure; Frequencies; Human; Individual; Left; Link; Maintenance; Measures; Modeling; Outcome; Parietal; Participant; Patients; Pattern; Performance; Periodicity; Phase; Physiological; Physiology; Population; Prefrontal Cortex; Procedures; Protocols documentation; Qualifying; Randomized; Research; Sampling; Scalp structure; Short-Term Memory; Task Performances; Techniques; Testing; Work; blind; cognitive function; cognitive neuroscience; design; efficacy testing; experience; improved; neural; neuropsychiatric disorder; neuropsychiatry; neuroregulation; noninvasive brain stimulation; novel; novel strategies; response; therapy development

ABSTRACT Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation technique that allows for frequency-specific entrainment of brain oscillations. Many cognitive functions are underpinned by oscillatory timing and patterns, and cognitive deficits in neuropsychiatric disorders are associated with disturbances in those patterns. tACS has the potential to synchronize rhythmic activity and mitigate cognitive deficits. However, a major challenge is that the effects of tACS on brain oscillations depend on the current brain state of the individual and on the timing of stimulation relative to the phase of ongoing oscillations. Using a working memory paradigm, we will address this challenge by investigating the state- dependent effects of tACS delivered to the left dorsolateral prefrontal cortex (DLPFC) on theta-gamma cross frequency coupling (tgCFC) and theta fronto-parietal phase synchronization, two EEG markers critical to working memory function. Specifically, in Aim 1, we will test the hypothesis that tACS with theta- nested gamma waveform delivered intermittently during key task epochs with strong tgCFC will improve cross-frequency interactions and frontoparietal phase synchrony during performance of a spatial working memory task, relative to tACS delivered with the same waveform during task-free epochs and sham stimulation. In Aim 2, we will test the hypothesis that closed-loop gamma tACS applied in phase with ongoing theta oscillations will enhance cross-frequency interactions and fronto-parietal phase synchronization relative to open-loop tACS with theta-nested gamma waveform. We will also determine the relationship between tACS-induced change in task performance and change in EEG markers across different stimulation conditions. These studies will help us identify reliable strategies to manipulate cross- frequency interactions between theta and gamma rhythms and to enhance phase synchronization between frontal and parietal regions, which support working memory function. They will also lay the groundwork for potential clinical trials that can test the efficacy of task-locked and closed-loop stimulation paradigms in clinical populations.

抽象的 经颅交流电流刺激（TACS）是一种无创神经调节技术，允许 用于特定于脑振荡的频率夹带。许多认知功能的基础 振荡时间和模式以及神经精神疾病的认知缺陷与 这些模式的干扰。 TACS有可能同步节奏活动并减轻 认知缺陷。但是，一个主要的挑战是TACS对脑振荡的影响取决于 相对于正在进行的阶段的个体的当前大脑状态和刺激的时间 振荡。使用工作记忆范式，我们将通过调查国家来应对这一挑战。 TAC的依赖性影响到左侧外侧前额叶皮层（DLPFC）对theta-gamma 跨频率耦合（TGCFC）和theta额叶 - 顶相同步，两个EEG标记 对工作记忆功能至关重要。具体而言，在AIM 1中，我们将检验以下假设： 在关键任务时期，嵌套的伽马波形用强的TGCFC进行了间歇性传递 跨频相互作用和在空间工作表现过程中的额叶相位同步 记忆任务，相对于在无任务时期和假时用相同波形传递的TACS 刺激。在AIM 2中，我们将测试以下假设。 持续的theta振荡将增强跨频相互作用和额叶阶段 相对于带有theta-nest的伽马波形的开环TACS的同步。我们还将确定 TAC引起的任务执行变化与跨越脑电图标记的变化之间的关系 不同的刺激条件。这些研究将帮助我们确定可靠的策略来操纵跨 theta和γ节律之间的频率相互作用并增强相位同步 在额叶和顶区域之间，支持工作记忆功能。他们还将放置 潜在临床试验的基础工作，可以测试任务锁定和闭环刺激的功效 临床人群中的范例。