State-dependent modulation of interactions of theta and gamma rhythms in working memory

工作记忆中θ节律和伽马节律相互作用的状态依赖性调节

• 批准号: 10740352
• 负责人: Joan A Camprodon
• 金额: $ 45.93万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2025-08-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10740352
• 关键词: Adult; Area; Biological Markers; Brain; Cephalic; Clinical; Clinical Trials; Cognition; Cognitive deficits; Cognitive remediation; Communication; Coupling; Double-Blind Method; Electroencephalography; Electrophysiology (science); Failure; Frequencies; Human; Individual; Left; Link; Maintenance; Measures; Modeling; Outcome; Parietal; Participant; Patients; Pattern; Performance; Periodicity; Phase; Physiological; Physiology; Population; Prefrontal Cortex; Procedures; Protocols documentation; Qualifying; Randomized; Research; Sampling; Scalp structure; Short-Term Memory; Task Performances; Techniques; Testing; Work; blind; cognitive function; cognitive neuroscience; design; efficacy testing; experience; improved; neural; neuropsychiatric disorder; neuropsychiatry; neuroregulation; noninvasive brain stimulation; novel; novel strategies; response; therapy development

ABSTRACT Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation technique that allows for frequency-specific entrainment of brain oscillations. Many cognitive functions are underpinned by oscillatory timing and patterns, and cognitive deficits in neuropsychiatric disorders are associated with disturbances in those patterns. tACS has the potential to synchronize rhythmic activity and mitigate cognitive deficits. However, a major challenge is that the effects of tACS on brain oscillations depend on the current brain state of the individual and on the timing of stimulation relative to the phase of ongoing oscillations. Using a working memory paradigm, we will address this challenge by investigating the state- dependent effects of tACS delivered to the left dorsolateral prefrontal cortex (DLPFC) on theta-gamma cross frequency coupling (tgCFC) and theta fronto-parietal phase synchronization, two EEG markers critical to working memory function. Specifically, in Aim 1, we will test the hypothesis that tACS with theta- nested gamma waveform delivered intermittently during key task epochs with strong tgCFC will improve cross-frequency interactions and frontoparietal phase synchrony during performance of a spatial working memory task, relative to tACS delivered with the same waveform during task-free epochs and sham stimulation. In Aim 2, we will test the hypothesis that closed-loop gamma tACS applied in phase with ongoing theta oscillations will enhance cross-frequency interactions and fronto-parietal phase synchronization relative to open-loop tACS with theta-nested gamma waveform. We will also determine the relationship between tACS-induced change in task performance and change in EEG markers across different stimulation conditions. These studies will help us identify reliable strategies to manipulate cross- frequency interactions between theta and gamma rhythms and to enhance phase synchronization between frontal and parietal regions, which support working memory function. They will also lay the groundwork for potential clinical trials that can test the efficacy of task-locked and closed-loop stimulation paradigms in clinical populations.

抽象的 经颅交流电刺激 (tACS) 是一种无创神经调节技术，可以 用于大脑振荡的特定频率夹带。许多认知功能的基础是 神经精神疾病的振荡时间和模式以及认知缺陷与 这些模式中的干扰。 tACS 有潜力同步节律活动并减轻 认知缺陷。然而，一个主要挑战是 tACS 对大脑振荡的影响取决于 个体当前的大脑状态以及相对于正在进行的阶段的刺激时间 振荡。使用工作记忆范式，我们将通过研究状态来应对这一挑战 传递到左背外侧前额叶皮层 (DLPFC) 的 tACS 对 θ-γ 的依赖性影响 交叉频率耦合 (tgCFC) 和 theta 额顶叶相位同步，两个 EEG 标记 对工作记忆功能至关重要。具体来说，在目标 1 中，我们将检验以下假设：tACS 与 theta- 在具有强大 tgCFC 的关键任务时期间歇性交付的嵌套伽马波形将得到改善 空间工作表现期间的跨频率相互作用和额顶相位同步 记忆任务，相对于在无任务时期和假期间以相同波形传递的 tACS 刺激。在目标 2 中，我们将测试闭环伽马 tACS 与 持续的 theta 振荡将增强跨频率相互作用和额顶叶相位 相对于具有 θ 嵌套伽玛波形的开环 tACS 的同步。我们还将确定 tACS 引起的任务表现变化与脑电图标记变化之间的关系 不同的刺激条件。这些研究将帮助我们确定可靠的策略来操纵交叉 theta 和 gamma 节律之间的频率相互作用并增强相位同步 位于额叶和顶叶区域之间，支持工作记忆功能。他们还将铺设 为潜在的临床试验奠定基础，可以测试任务锁定和闭环刺激的功效 临床人群中的范例。